TAFA4_MOUSE
ID TAFA4_MOUSE Reviewed; 135 AA.
AC Q7TPG5; Q5FWC0; Q8BV02;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Chemokine-like protein TAFA-4 {ECO:0000305};
DE Flags: Precursor;
GN Name=Tafa4; Synonyms=Fam19a4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6J;
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Head, and Retina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Molar;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX PubMed=24139797; DOI=10.1016/j.celrep.2013.09.013;
RA Delfini M.C., Mantilleri A., Gaillard S., Hao J., Reynders A., Malapert P.,
RA Alonso S., Francois A., Barrere C., Seal R., Landry M., Eschallier A.,
RA Alloui A., Bourinet E., Delmas P., Le Feuvre Y., Moqrich A.;
RT "TAFA4, a chemokine-like protein, modulates injury-induced mechanical and
RT chemical pain hypersensitivity in mice.";
RL Cell Rep. 5:378-388(2013).
RN [5]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND INDUCTION BY LPS.
RX PubMed=25109685; DOI=10.1038/cmi.2014.61;
RA Wang W., Li T., Wang X., Yuan W., Cheng Y., Zhang H., Xu E., Zhang Y.,
RA Shi S., Ma D., Han W.;
RT "FAM19A4 is a novel cytokine ligand of formyl peptide receptor 1 (FPR1) and
RT is able to promote the migration and phagocytosis of macrophages.";
RL Cell. Mol. Immunol. 12:615-624(2015).
CC -!- FUNCTION: Modulates injury-induced and chemical pain hypersensitivity
CC (PubMed:24139797). Ligand of FPR1, can chemoattract macrophages,
CC promote phagocytosis and increase ROS release (PubMed:25109685).
CC {ECO:0000269|PubMed:24139797, ECO:0000269|PubMed:25109685}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q96LR4}.
CC -!- TISSUE SPECIFICITY: Expressed in a descrete subset of dorsal root
CC ganglia neurons called C-low-threshold mechanoreceptors (at protein
CC level) (PubMed:24139797). Expressed in LPS-stimulated monocytes and
CC macrophages, especially in polarized M1 (PubMed:25109685).
CC {ECO:0000269|PubMed:24139797, ECO:0000269|PubMed:25109685}.
CC -!- INDUCTION: Up-regulated in LPS-stimulated monocytes and macrophages,
CC especially in polarized M1. {ECO:0000269|PubMed:25109685}.
CC -!- DISRUPTION PHENOTYPE: Mutant mice exhibit enhanced mechanical and
CC chemical hypersensitivity following inflammation and nerve injury.
CC {ECO:0000269|PubMed:24139797}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC38247.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY325123; AAP92415.1; -; mRNA.
DR EMBL; AK081531; BAC38247.1; ALT_FRAME; mRNA.
DR EMBL; AK149355; BAE28831.1; -; mRNA.
DR EMBL; BC089490; AAH89490.1; -; mRNA.
DR CCDS; CCDS51858.1; -.
DR RefSeq; NP_796207.2; NM_177233.5.
DR RefSeq; XP_017177137.1; XM_017321648.1.
DR AlphaFoldDB; Q7TPG5; -.
DR STRING; 10090.ENSMUSP00000086710; -.
DR PaxDb; Q7TPG5; -.
DR PRIDE; Q7TPG5; -.
DR Antibodypedia; 46378; 108 antibodies from 14 providers.
DR Ensembl; ENSMUST00000089295; ENSMUSP00000086710; ENSMUSG00000046500.
DR GeneID; 320701; -.
DR KEGG; mmu:320701; -.
DR UCSC; uc009dah.1; mouse.
DR CTD; 151647; -.
DR MGI; MGI:2444563; Tafa4.
DR VEuPathDB; HostDB:ENSMUSG00000046500; -.
DR eggNOG; ENOG502RZN9; Eukaryota.
DR GeneTree; ENSGT00940000159882; -.
DR HOGENOM; CLU_126078_3_0_1; -.
DR InParanoid; Q7TPG5; -.
DR OMA; HWVFLAY; -.
DR OrthoDB; 1371619at2759; -.
DR PhylomeDB; Q7TPG5; -.
DR TreeFam; TF331749; -.
DR BioGRID-ORCS; 320701; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tafa4; mouse.
DR PRO; PR:Q7TPG5; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q7TPG5; protein.
DR Bgee; ENSMUSG00000046500; Expressed in lumbar dorsal root ganglion and 66 other tissues.
DR Genevisible; Q7TPG5; MM.
DR GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR GO; GO:0048018; F:receptor ligand activity; IDA:UniProtKB.
DR GO; GO:0048246; P:macrophage chemotaxis; IDA:UniProtKB.
DR GO; GO:0006909; P:phagocytosis; IDA:UniProtKB.
DR GO; GO:0042391; P:regulation of membrane potential; IMP:MGI.
DR GO; GO:0051930; P:regulation of sensory perception of pain; IMP:MGI.
DR GO; GO:0010469; P:regulation of signaling receptor activity; IDA:UniProtKB.
DR GO; GO:0042554; P:superoxide anion generation; IDA:UniProtKB.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR Pfam; PF12020; TAFA; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..135
FT /note="Chemokine-like protein TAFA-4"
FT /id="PRO_0000042730"
FT CONFLICT 3
FT /note="V -> A (in Ref. 3; AAH89490)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 135 AA; 15018 MW; 38C83231992D3907 CRC64;
MRVCAKWVLL SRWLVLTYVL MVCCKLMSAS SQHLRGHAGH HLIKPGTCEV VAVHRCCNKN
RIEERSQTVK CSCFPGQVAG TTRAQPSCVE AAIVIEKWWC HMNPCLEGED CKVLPDSSGW
SCSSGNKVKT TKVTR
