ID   TAFA5_BOVIN             Reviewed;         132 AA.
AC   Q3ZBS2;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Chemokine-like protein TAFA-5;
DE   Flags: Precursor;
GN   Name=TAFA5; Synonyms=FAM19A5;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Kidney;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a chemokine-like protein by regulating cell
CC       proliferation and migration through activation of G protein-coupled
CC       receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates
CC       chemotactic migration of macrophages mediated by the MAPK3/ERK1 and
CC       AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast
CC       formation from macrophages by inhibiting up-regulation of osteoclast
CC       fusogenic and differentiation genes (By similarity). Stimulation of
CC       macrophage migration and inhibition of osteoclast formation is mediated
CC       through the GPCR FPR2 (By similarity). Acts as an adipokine by
CC       negatively regulating vascular smooth muscle cell (VSMC) proliferation
CC       and migration in response to platelet-derived growth factor stimulation
CC       via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By
CC       similarity). Inhibits injury-induced cell proliferation and neointima
CC       formation in the femoral arteries (By similarity).
CC       {ECO:0000250|UniProtKB:M0R7X9, ECO:0000250|UniProtKB:Q91WE9}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q7Z5A7}.
CC   -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI03141.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC103140; AAI03141.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001070468.1; NM_001077000.1.
DR   AlphaFoldDB; Q3ZBS2; -.
DR   STRING; 9913.ENSBTAP00000031185; -.
DR   PaxDb; Q3ZBS2; -.
DR   GeneID; 767927; -.
DR   KEGG; bta:767927; -.
DR   CTD; 25817; -.
DR   eggNOG; ENOG502RZT2; Eukaryota.
DR   HOGENOM; CLU_126078_5_1_1; -.
DR   InParanoid; Q3ZBS2; -.
DR   OrthoDB; 1417753at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; IBA:GO_Central.
DR   GO; GO:0048018; F:receptor ligand activity; IBA:GO_Central.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR020350; Chemokine-like_TAFA.
DR   InterPro; IPR040329; TAFA-5.
DR   PANTHER; PTHR31878; PTHR31878; 1.
DR   Pfam; PF12020; TAFA; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..43
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z5A7"
FT   CHAIN           44..132
FT                   /note="Chemokine-like protein TAFA-5"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z5A7"
FT                   /id="PRO_0000042731"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   132 AA;  14329 MW;  0870D51874FBB066 CRC64;
     MAPSPRTGSR QDATALPSMS STFWAFMILA SLLIAYCSQL AAGTCEIVTL DRDSSQPRRT
     IARQTARCAC RKGQIAGTTR ARPACVDARI IRTKQWCDML PCLEGEGCDL LINRSGWTCT
     QPGGRIKTTT VS