TAFA5_HUMAN
ID TAFA5_HUMAN Reviewed; 132 AA.
AC Q7Z5A7; A6NII9; B0QZ13; B0QZ14; B0QZ15; O95902; Q5H9C4; Q6UWC9; Q8IXR8;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Chemokine-like protein TAFA-5 {ECO:0000305};
DE Flags: Precursor;
GN Name=TAFA5 {ECO:0000312|HGNC:HGNC:21592};
GN Synonyms=FAM19A5 {ECO:0000312|HGNC:HGNC:21592}; ORFNames=UNQ5208/PRO34524;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY, AND SUBCELLULAR
RP LOCATION.
RX PubMed=15028294; DOI=10.1016/j.ygeno.2003.10.006;
RA Tom Tang Y., Emtage P., Funk W.D., Hu T., Arterburn M., Park E.E., Rupp F.;
RT "TAFA: a novel secreted family with conserved cysteine residues and
RT restricted expression in the brain.";
RL Genomics 83:727-734(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Mei G., Yu W., Gibbs R.A.;
RL Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Neuroblastoma, and Subthalamic nucleus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10591208; DOI=10.1038/990031;
RA Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M.,
RA Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C.,
RA Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E.,
RA Bridgeman A.M., Buck D., Burgess J., Burrill W.D., Burton J., Carder C.,
RA Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G.,
RA Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V.,
RA Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M.,
RA Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A.,
RA Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C.,
RA Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E.,
RA Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F.,
RA Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M.,
RA Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A.,
RA Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D.,
RA Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y.,
RA Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S.,
RA Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E.,
RA Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L.,
RA Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L.,
RA Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N.,
RA Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A.,
RA Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L.,
RA Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P.,
RA Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P.,
RA Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q.,
RA Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J.,
RA Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J.,
RA Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D.,
RA Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T.,
RA Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P.,
RA Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K.,
RA Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R.,
RA Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L.,
RA McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J.,
RA Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E.,
RA Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P.,
RA Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y.,
RA Wright H.;
RT "The DNA sequence of human chromosome 22.";
RL Nature 402:489-495(1999).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hypothalamus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP PROTEIN SEQUENCE OF 44-53 (ISOFORMS 1 AND 2), SUBCELLULAR LOCATION, AND
RP TISSUE SPECIFICITY.
RX PubMed=29453251; DOI=10.1161/circulationaha.117.032398;
RA Wang Y., Chen D., Zhang Y., Wang P., Zheng C., Zhang S., Yu B., Zhang L.,
RA Zhao G., Ma B., Cai Z., Xie N., Huang S., Liu Z., Mo X., Guan Y., Wang X.,
RA Fu Y., Ma D., Wang Y., Kong W.;
RT "Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
RT Through Sphingosine-1-Phosphate Receptor 2.";
RL Circulation 138:48-63(2018).
CC -!- FUNCTION: Acts as a chemokine-like protein by regulating cell
CC proliferation and migration through activation of G protein-coupled
CC receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates
CC chemotactic migration of macrophages mediated by the MAPK3/ERK1 and
CC AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast
CC formation from macrophages by inhibiting up-regulation of osteoclast
CC fusogenic and differentiation genes (By similarity). Stimulation of
CC macrophage migration and inhibition of osteoclast formation is mediated
CC via GPCR FPR2 (By similarity). Acts as an adipokine by negatively
CC regulating vascular smooth muscle cell (VSMC) proliferation and
CC migration in response to platelet-derived growth factor stimulation via
CC GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By
CC similarity). Inhibits injury-induced cell proliferation and neointima
CC formation in the femoral arteries (By similarity).
CC {ECO:0000250|UniProtKB:M0R7X9, ECO:0000250|UniProtKB:Q91WE9}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15028294,
CC ECO:0000269|PubMed:29453251}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q7Z5A7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z5A7-2; Sequence=VSP_016068;
CC Name=3;
CC IsoId=Q7Z5A7-3; Sequence=VSP_035191;
CC -!- TISSUE SPECIFICITY: Expressed in the subcutaneous and perirenal adipose
CC tissue (at protein level) (PubMed:29453251). Highly expressed in
CC adipose tissue with moderate expression in the brain and ovary
CC (PubMed:29453251). Isoform 2: Brain-specific (PubMed:15028294).
CC {ECO:0000269|PubMed:15028294, ECO:0000269|PubMed:29453251}.
CC -!- MISCELLANEOUS: [Isoform 2]: Contains a predicted signal peptide at
CC positions 1-25. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD20061.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH39396.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY325118; AAP92410.1; -; mRNA.
DR EMBL; AF131851; AAD20061.1; ALT_INIT; mRNA.
DR EMBL; AY358847; AAQ89206.1; -; mRNA.
DR EMBL; AK123443; BAG53905.1; -; mRNA.
DR EMBL; AK125256; BAG54175.1; -; mRNA.
DR EMBL; AL096843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL096853; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z83837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Z84468; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC039396; AAH39396.2; ALT_INIT; mRNA.
DR CCDS; CCDS46728.1; -. [Q7Z5A7-1]
DR CCDS; CCDS46729.1; -. [Q7Z5A7-2]
DR RefSeq; NP_001076436.1; NM_001082967.2. [Q7Z5A7-1]
DR RefSeq; NP_056196.2; NM_015381.6. [Q7Z5A7-2]
DR AlphaFoldDB; Q7Z5A7; -.
DR BioGRID; 117345; 23.
DR IntAct; Q7Z5A7; 1.
DR MINT; Q7Z5A7; -.
DR STRING; 9606.ENSP00000383933; -.
DR GlyGen; Q7Z5A7; 1 site.
DR iPTMnet; Q7Z5A7; -.
DR PhosphoSitePlus; Q7Z5A7; -.
DR BioMuta; FAM19A5; -.
DR DMDM; 205371754; -.
DR MassIVE; Q7Z5A7; -.
DR PaxDb; Q7Z5A7; -.
DR PeptideAtlas; Q7Z5A7; -.
DR PRIDE; Q7Z5A7; -.
DR ProteomicsDB; 69275; -. [Q7Z5A7-1]
DR ProteomicsDB; 69276; -. [Q7Z5A7-2]
DR ProteomicsDB; 69277; -. [Q7Z5A7-3]
DR Antibodypedia; 67212; 19 antibodies from 13 providers.
DR DNASU; 25817; -.
DR Ensembl; ENST00000358295.9; ENSP00000351043.5; ENSG00000219438.9. [Q7Z5A7-2]
DR Ensembl; ENST00000402357.6; ENSP00000383933.2; ENSG00000219438.9. [Q7Z5A7-1]
DR Ensembl; ENST00000406880.1; ENSP00000385603.1; ENSG00000219438.9. [Q7Z5A7-3]
DR GeneID; 25817; -.
DR KEGG; hsa:25817; -.
DR MANE-Select; ENST00000402357.6; ENSP00000383933.2; NM_001082967.3; NP_001076436.1.
DR UCSC; uc003bim.6; human. [Q7Z5A7-1]
DR CTD; 25817; -.
DR DisGeNET; 25817; -.
DR GeneCards; TAFA5; -.
DR HGNC; HGNC:21592; TAFA5.
DR HPA; ENSG00000219438; Tissue enriched (brain).
DR MIM; 617499; gene.
DR neXtProt; NX_Q7Z5A7; -.
DR OpenTargets; ENSG00000219438; -.
DR PharmGKB; PA134887312; -.
DR VEuPathDB; HostDB:ENSG00000219438; -.
DR eggNOG; ENOG502RZT2; Eukaryota.
DR GeneTree; ENSGT00940000160682; -.
DR HOGENOM; CLU_126078_5_0_1; -.
DR InParanoid; Q7Z5A7; -.
DR OMA; DANAWPR; -.
DR OrthoDB; 1417753at2759; -.
DR PhylomeDB; Q7Z5A7; -.
DR TreeFam; TF331749; -.
DR PathwayCommons; Q7Z5A7; -.
DR SignaLink; Q7Z5A7; -.
DR BioGRID-ORCS; 25817; 13 hits in 1066 CRISPR screens.
DR ChiTaRS; FAM19A5; human.
DR GeneWiki; FAM19A5; -.
DR GenomeRNAi; 25817; -.
DR Pharos; Q7Z5A7; Tdark.
DR PRO; PR:Q7Z5A7; -.
DR Proteomes; UP000005640; Chromosome 22.
DR RNAct; Q7Z5A7; protein.
DR Bgee; ENSG00000219438; Expressed in cerebellar vermis and 151 other tissues.
DR ExpressionAtlas; Q7Z5A7; baseline and differential.
DR Genevisible; Q7Z5A7; HS.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0001664; F:G protein-coupled receptor binding; IPI:MGI.
DR GO; GO:0048018; F:receptor ligand activity; IPI:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI.
DR GO; GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IDA:MGI.
DR GO; GO:0061044; P:negative regulation of vascular wound healing; IEA:Ensembl.
DR InterPro; IPR020350; Chemokine-like_TAFA.
DR InterPro; IPR040329; TAFA-5.
DR PANTHER; PTHR31878; PTHR31878; 1.
DR Pfam; PF12020; TAFA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytokine; Direct protein sequencing; Glycoprotein;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..43
FT /evidence="ECO:0000269|PubMed:29453251"
FT CHAIN 44..132
FT /note="Chemokine-like protein TAFA-5"
FT /evidence="ECO:0000305|PubMed:29453251"
FT /id="PRO_0000042732"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 1..87
FT /note="MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDR
FT DSSQPRRTIARQTARCACRKGQIAGTTRARPACVD -> MYHHREWP (in isoform
FT 3)"
FT /evidence="ECO:0000305"
FT /id="VSP_035191"
FT VAR_SEQ 1..38
FT /note="MAPSPRTGSRQDATALPSMSSTFWAFMILASLLIAYCS -> MQLLKALWAL
FT AGAALCCFLVLVIHAQFLKEG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:14702039, ECO:0000303|PubMed:15028294"
FT /id="VSP_016068"
FT CONFLICT Q7Z5A7-2:11..23
FT /note="AGAALCCFLVLVI -> V (in Ref. 3; AAQ89206)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 132 AA; 14301 MW; 16BFE9F574FBB066 CRC64;
MAPSPRTGSR QDATALPSMS STFWAFMILA SLLIAYCSQL AAGTCEIVTL DRDSSQPRRT
IARQTARCAC RKGQIAGTTR ARPACVDARI IKTKQWCDML PCLEGEGCDL LINRSGWTCT
QPGGRIKTTT VS
