ID   TAFA5_RAT               Reviewed;         132 AA.
AC   M0R7X9;
DT   07-NOV-2018, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2013, sequence version 1.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Chemokine-like protein TAFA-5;
DE   Flags: Precursor;
GN   Name=Tafa5; Synonyms=Fam19a5 {ECO:0000312|RGD:1562115};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000312|Proteomes:UP000002494};
RN   [1] {ECO:0000312|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000312|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [2]
RP   TISSUE SPECIFICITY, AND INDUCTION BY WATER DEPRIVATION.
RX   PubMed=18275939; DOI=10.1016/j.brainres.2007.12.074;
RA   Paulsen S.J., Christensen M.T., Vrang N., Larsen L.K.;
RT   "The putative neuropeptide TAFA5 is expressed in the hypothalamic
RT   paraventricular nucleus and is regulated by dehydration.";
RL   Brain Res. 1199:1-9(2008).
RN   [3] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX   PubMed=29453251; DOI=10.1161/circulationaha.117.032398;
RA   Wang Y., Chen D., Zhang Y., Wang P., Zheng C., Zhang S., Yu B., Zhang L.,
RA   Zhao G., Ma B., Cai Z., Xie N., Huang S., Liu Z., Mo X., Guan Y., Wang X.,
RA   Fu Y., Ma D., Wang Y., Kong W.;
RT   "Novel Adipokine, FAM19A5, Inhibits Neointima Formation After Injury
RT   Through Sphingosine-1-Phosphate Receptor 2.";
RL   Circulation 138:48-63(2018).
CC   -!- FUNCTION: Acts as a chemokine-like protein by regulating cell
CC       proliferation and migration through activation of G protein-coupled
CC       receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251). Stimulates
CC       chemotactic migration of macrophages mediated by the MAPK3/ERK1 and
CC       AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast
CC       formation from macrophages by inhibiting up-regulation of osteoclast
CC       fusogenic and differentiation genes (By similarity). Stimulation of
CC       macrophage migration and inhibition of osteoclast formation is mediated
CC       through the GPCR FPR2 (By similarity). Acts as a adipokine by
CC       negatively regulating vascular smooth muscle cell (VSMC) proliferation
CC       and migration in response to platelet-derived growth factor stimulation
CC       via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling
CC       (PubMed:29453251). Inhibits injury-induced cell proliferation and
CC       neointima formation in the femoral arteries (PubMed:29453251).
CC       {ECO:0000250|UniProtKB:Q91WE9, ECO:0000269|PubMed:29453251}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29453251}.
CC   -!- TISSUE SPECIFICITY: Expressed in the epididymal adipose tissue, in
CC       aortic adventitial fibroblasts and low expression in vascular smooth
CC       muscle cells (at protein level) (PubMed:29453251). Expressed in the
CC       central nervous system, highly expressed in the hypothalamic
CC       paraventricular nucleus (PubMed:29453251).
CC       {ECO:0000269|PubMed:29453251}.
CC   -!- INDUCTION: Repressed in adipocytes after stimulation with Tnfa, Il6 and
CC       Ins1 (PubMed:29453251). Specifically down-regulated in the hypothalamic
CC       paraventricular nucleus following water deprivation (PubMed:29453251).
CC       {ECO:0000269|PubMed:29453251}.
CC   -!- SIMILARITY: Belongs to the TAFA family. {ECO:0000305}.
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DR   EMBL; AABR07058626; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07058627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07058628; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07058629; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07058630; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07058631; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AABR07058632; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001178920.1; NM_001191991.1.
DR   AlphaFoldDB; M0R7X9; -.
DR   STRING; 10116.ENSRNOP00000065567; -.
DR   GlyGen; M0R7X9; 1 site.
DR   PaxDb; M0R7X9; -.
DR   Ensembl; ENSRNOT00000074625; ENSRNOP00000065567; ENSRNOG00000049349.
DR   GeneID; 500915; -.
DR   KEGG; rno:500915; -.
DR   CTD; 25817; -.
DR   RGD; 1562115; Tafa5.
DR   eggNOG; ENOG502RZT2; Eukaryota.
DR   GeneTree; ENSGT00940000160682; -.
DR   HOGENOM; CLU_126078_5_0_1; -.
DR   InParanoid; M0R7X9; -.
DR   OMA; DANAWPR; -.
DR   OrthoDB; 1417753at2759; -.
DR   PRO; PR:M0R7X9; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000049349; Expressed in frontal cortex and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0001664; F:G protein-coupled receptor binding; ISO:RGD.
DR   GO; GO:0048018; F:receptor ligand activity; IDA:MGI.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:MGI.
DR   GO; GO:1904753; P:negative regulation of vascular associated smooth muscle cell migration; IDA:MGI.
DR   GO; GO:1904706; P:negative regulation of vascular associated smooth muscle cell proliferation; IDA:MGI.
DR   GO; GO:0061044; P:negative regulation of vascular wound healing; IDA:MGI.
DR   InterPro; IPR020350; Chemokine-like_TAFA.
DR   InterPro; IPR040329; TAFA-5.
DR   PANTHER; PTHR31878; PTHR31878; 1.
DR   Pfam; PF12020; TAFA; 1.
PE   1: Evidence at protein level;
KW   Cytokine; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..43
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z5A7"
FT   CHAIN           44..132
FT                   /note="Chemokine-like protein TAFA-5"
FT                   /evidence="ECO:0000250|UniProtKB:Q7Z5A7"
FT                   /id="PRO_0000445700"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   132 AA;  14331 MW;  16BFF4357D3BA466 CRC64;
     MAPSPRTSSR QDATALPSMS STFWAFMILA SLLIAYCSQL AAGTCEIVTL DRDSSQPRRT
     IARQTARCAC RKGQIAGTTR ARPACVDARI IKTKQWCDML PCLEGEGCDL LINRSGWTCT
     QPGGRIKTTT VS