ID   TAG52_CAEEL             Reviewed;         665 AA.
AC   Q11100;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Putative protein tag-52;
GN   Name=tag-52; ORFNames=C02F12.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
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DR   EMBL; FO080254; CCD62375.1; -; Genomic_DNA.
DR   PIR; T34079; T34079.
DR   RefSeq; NP_508633.1; NM_076232.3.
DR   AlphaFoldDB; Q11100; -.
DR   SMR; Q11100; -.
DR   BioGRID; 45595; 2.
DR   DIP; DIP-26290N; -.
DR   IntAct; Q11100; 2.
DR   MINT; Q11100; -.
DR   STRING; 6239.C02F12.4; -.
DR   iPTMnet; Q11100; -.
DR   EPD; Q11100; -.
DR   PaxDb; Q11100; -.
DR   PeptideAtlas; Q11100; -.
DR   EnsemblMetazoa; C02F12.4.1; C02F12.4.1; WBGene00006431.
DR   GeneID; 180657; -.
DR   KEGG; cel:CELE_C02F12.4; -.
DR   UCSC; C02F12.4; c. elegans.
DR   CTD; 180657; -.
DR   WormBase; C02F12.4; CE03899; WBGene00006431; tag-52.
DR   eggNOG; KOG4424; Eukaryota.
DR   GeneTree; ENSGT00940000163420; -.
DR   HOGENOM; CLU_432260_0_0_1; -.
DR   InParanoid; Q11100; -.
DR   OMA; PWWETES; -.
DR   OrthoDB; 619764at2759; -.
DR   PhylomeDB; Q11100; -.
DR   PRO; PR:Q11100; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006431; Expressed in embryo and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; SSF48065; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome.
FT   CHAIN           1..665
FT                   /note="Putative protein tag-52"
FT                   /id="PRO_0000080991"
FT   DOMAIN          54..227
FT                   /note="DH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT   REGION          456..489
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..484
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   665 AA;  76818 MW;  909FB2E03EA76AA6 CRC64;
     MNAGKEFNYY TYQSDSSQGS LQKAPDENTD YFTHKMNSYL PFDMSTLYAN QPTEKIQILQ
     EIYDTERTYV KALTIVDEIF IQQLNLWCPK SKKCFRSMFG EISAICKTHQ ILLESLQCKP
     IAEVFTKFVP FLKLYTSYAS HYPNSLKIFA KLMSRNDFRK ALTKIEEDPR VDGKKLQTYL
     IMPIQRIPRY IMLIQNLMNY STEKDDMTNL YKALSGMQGL SDQIQSCMTA YENGERLLQI
     QLNFGLDGHI LEPGRVLLKE GMLYKRELNG SANYQETVVF LFNDILLYGI KRISVMPLCK
     YEPSAILSLR HCIVQLDDIG GSIFIRCGDV GVDFTAYSLG GVTEWYNEIC DAIDNAKKLR
     DTLRKESFKQ KSLIFDKGFW QRNRDKLRNM ITADMTGNIS RVLTRKKPAP KLEESDFLRG
     QWTTSTIASN QRKRKVATLE DEEEDVFNML SSPNLSQRKR KATLQENTPS GVGWTASPRS
     SSFRKRRAST LRNKNADVTD GNNYLSHLVL NDVTMTQPYT GLNAFVGTPK SRTPTDDDYD
     SDRDYVWTDD EEFVSDDKKI PIRRVASYDE EDRRPRDFSE VRRSVASEPP RRHLAVDDIR
     KLSYQQRSLE PFNMVTEDDD EDDIIDIKVK GERPRPWWET ESAPPAIKNQ KSSIIDSIRN
     SCAIM