ID   TAG76_CAEEL             Reviewed;        1040 AA.
AC   P34681; Q7JMT0; Q9TW94;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Putative protein tag-76;
GN   Name=tag-76; ORFNames=ZK757.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=7906398; DOI=10.1038/368032a0;
RA   Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA   Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA   Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA   Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA   Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA   Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA   Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA   Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA   Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA   Wilkinson-Sproat J., Wohldman P.;
RT   "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT   elegans.";
RL   Nature 368:32-38(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND ALTERNATIVE SPLICING.
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=a;
CC         IsoId=P34681-1; Sequence=Displayed;
CC       Name=b;
CC         IsoId=P34681-2; Sequence=VSP_011900;
CC       Name=c;
CC         IsoId=P34681-3; Sequence=VSP_011901, VSP_011902;
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DR   EMBL; Z29121; CAA82389.1; -; Genomic_DNA.
DR   EMBL; Z30215; CAA82389.1; JOINED; Genomic_DNA.
DR   EMBL; Z29121; CAB54514.1; -; Genomic_DNA.
DR   EMBL; Z30215; CAB54514.1; JOINED; Genomic_DNA.
DR   EMBL; Z30215; CAB54245.1; -; Genomic_DNA.
DR   PIR; D88568; D88568.
DR   PIR; S41013; S41013.
DR   RefSeq; NP_499191.1; NM_066790.3. [P34681-1]
DR   RefSeq; NP_499192.1; NM_066791.4. [P34681-2]
DR   RefSeq; NP_499193.1; NM_066792.3. [P34681-3]
DR   AlphaFoldDB; P34681; -.
DR   SMR; P34681; -.
DR   STRING; 6239.ZK757.3a.1; -.
DR   PaxDb; P34681; -.
DR   PRIDE; P34681; -.
DR   EnsemblMetazoa; ZK757.3a.1; ZK757.3a.1; WBGene00006449. [P34681-1]
DR   EnsemblMetazoa; ZK757.3a.2; ZK757.3a.2; WBGene00006449. [P34681-1]
DR   EnsemblMetazoa; ZK757.3b.1; ZK757.3b.1; WBGene00006449. [P34681-2]
DR   EnsemblMetazoa; ZK757.3c.1; ZK757.3c.1; WBGene00006449. [P34681-3]
DR   GeneID; 176400; -.
DR   KEGG; cel:CELE_ZK757.3; -.
DR   UCSC; ZK757.3b; c. elegans. [P34681-1]
DR   CTD; 176400; -.
DR   WormBase; ZK757.3a; CE01117; WBGene00006449; tag-76.
DR   WormBase; ZK757.3b; CE24737; WBGene00006449; tag-76.
DR   WormBase; ZK757.3c; CE24738; WBGene00006449; tag-76.
DR   eggNOG; KOG1041; Eukaryota.
DR   GeneTree; ENSGT00940000174399; -.
DR   InParanoid; P34681; -.
DR   OMA; ARIFCKY; -.
DR   OrthoDB; 159407at2759; -.
DR   PhylomeDB; P34681; -.
DR   Reactome; R-CEL-203927; MicroRNA (miRNA) biogenesis.
DR   Reactome; R-CEL-426486; Small interfering RNA (siRNA) biogenesis.
DR   Reactome; R-CEL-5578749; Transcriptional regulation by small RNAs.
DR   PRO; PR:P34681; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00006449; Expressed in larva and 1 other tissue.
DR   GO; GO:0005737; C:cytoplasm; ISS:WormBase.
DR   GO; GO:0043186; C:P granule; ISS:WormBase.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0035198; F:miRNA binding; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003727; F:single-stranded RNA binding; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IMP:WormBase.
DR   CDD; cd04657; Piwi_ago-like; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR014811; ArgoL1.
DR   InterPro; IPR032472; ArgoL2.
DR   InterPro; IPR032473; Argonaute_Mid_dom.
DR   InterPro; IPR032474; Argonaute_N.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR003165; Piwi.
DR   InterPro; IPR045246; Piwi_ago-like.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   Pfam; PF08699; ArgoL1; 1.
DR   Pfam; PF16488; ArgoL2; 1.
DR   Pfam; PF16487; ArgoMid; 1.
DR   Pfam; PF16486; ArgoN; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF02171; Piwi; 1.
DR   SMART; SM01163; DUF1785; 1.
DR   SMART; SM00950; Piwi; 1.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS50822; PIWI; 1.
PE   4: Predicted;
KW   Alternative splicing; Reference proteome.
FT   CHAIN           1..1040
FT                   /note="Putative protein tag-76"
FT                   /id="PRO_0000065547"
FT   DOMAIN          378..486
FT                   /note="PAZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00142"
FT   DOMAIN          660..966
FT                   /note="Piwi"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00150"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..367
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         19..55
FT                   /note="GISGSGSMSPPITSRPASGQASPLTSNGSLSPPQYAD -> EGLTSGVFSWA
FT                   LERLPTCLREELQLPLTDTGSCWQTN (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_011901"
FT   VAR_SEQ         19..21
FT                   /note="Missing (in isoform b)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_011900"
FT   VAR_SEQ         56..1040
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_011902"
SQ   SEQUENCE   1040 AA;  115416 MW;  4C8483C1F1D72338 CRC64;
     MSRRNATSFV DNNTLTSSGI SGSGSMSPPI TSRPASGQAS PLTSNGSLSP PQYADDQGSV
     SYNLDSPRDL SPLLLSELAC LNMREVVARP GLGTIGRQIP VKSNFFAMDL KNPKMVVIQY
     HVEIHHPGCR KLDKDEMRII FWKAVSDHPN IFHNKFALAY DGAHQLYTVA RLEFPDDQGS
     VRLDCEASLP KDNRDRTRCA ISIQNVGPVL LEMQRTRTNN LDERVLTPIQ ILDIICRQSL
     TCPLLKNSAN FYTWKSSCYR IPTAAGQALD LEGGKEMWTG FFSSAHIASN YRPLLNIDVA
     HTAFYKTRIT VLQFMCDVLN ERTSKPNRNN PRGPGGPGGP GGYRGGRGGG RGGSYGNFGN
     RGPPGANVRD DFGGNGLTFT MDTLSRDTQL SSFETRIFGD AIRGMKIRAA HRPNAIRVYK
     VNSLQLPADK LMFQGIDEEG RQVVCSVADY FSEKYGPLKY PKLPCLHVGP PTRNIFLPME
     HCLIDSPQKY NKKMSEKQTS AIIKAAAVDA TQREDRIKQL AAQASFGTDP FLKEFGVAVS
     SQMIQTTARV IQPPPIMFGG NNRSVNPVVF PKDGSWTMDN QTLYMPATCR SYSMIALVDP
     RDQTSLQTFC QSLTMKATAM GMNFPRWPDL VKYGRSKEDV CTLFTEIADE YRVTNTVCDC
     IIVVLQSKNS DIYMTVKEQS DIVHGIMSQC VLMKNVSRPT PATCANIVLK LNMKMGGINS
     RIVADKITNK YLVDQPTMVV GIDVTHPTQA EMRMNMPSVA AIVANVDLLP QSYGANVKVQ
     KKCRESVVYL LDAIRERIIT FYRHTKQKPA RIIVYRDGVS EGQFSEVLRE EIQSIRTACL
     AIAEDFRPPI TYIVVQKRHH ARIFCKYQND MVGKAKNVPP GTTVDTGIVS PEGFDFYLCS
     HYGVQGTSRP ARYHVLLDEC KFTADEIQSI TYGMCHTYGR CTRSVSIPTP VYYADLVATR
     ARCHVKRKLG LADNNDCDTN SRSSTLASLL NVRTGSGKGK KSYAPSVDDE SYSLSDATSD
     QILQDCVSVA TDFKSRMYFI