TAGH_LACLA
ID TAGH_LACLA Reviewed; 466 AA.
AC Q9CH26;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Teichoic acids export ATP-binding protein TagH {ECO:0000255|HAMAP-Rule:MF_01715};
DE EC=7.5.2.4 {ECO:0000255|HAMAP-Rule:MF_01715};
GN Name=tagH {ECO:0000255|HAMAP-Rule:MF_01715}; OrderedLocusNames=LL0915;
GN ORFNames=L137446;
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403;
RX PubMed=11337471; DOI=10.1101/gr.gr-1697r;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- FUNCTION: Part of the ABC transporter complex TagGH involved in
CC teichoic acids export. Responsible for energy coupling to the transport
CC system. {ECO:0000255|HAMAP-Rule:MF_01715}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + teichoic acidSide 1 = ADP + phosphate + teichoic
CC acidSide 2.; EC=7.5.2.4; Evidence={ECO:0000255|HAMAP-Rule:MF_01715};
CC -!- SUBUNIT: The complex is composed of two ATP-binding proteins (TagH) and
CC two transmembrane proteins (TagG). {ECO:0000255|HAMAP-Rule:MF_01715}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01715};
CC Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01715}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. Teichoic acids
CC exporter (TC 3.A.1.104.1) family. {ECO:0000255|HAMAP-Rule:MF_01715}.
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DR EMBL; AE005176; AAK05013.1; -; Genomic_DNA.
DR PIR; C86739; C86739.
DR RefSeq; NP_267071.1; NC_002662.1.
DR RefSeq; WP_003131432.1; NC_002662.1.
DR AlphaFoldDB; Q9CH26; -.
DR SMR; Q9CH26; -.
DR STRING; 272623.L137446; -.
DR PaxDb; Q9CH26; -.
DR EnsemblBacteria; AAK05013; AAK05013; L137446.
DR KEGG; lla:L137446; -.
DR PATRIC; fig|272623.7.peg.980; -.
DR eggNOG; COG1134; Bacteria.
DR eggNOG; COG1388; Bacteria.
DR HOGENOM; CLU_000604_101_8_9; -.
DR OMA; RRDEPRM; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015438; F:ABC-type teichoic acid transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR CDD; cd03220; ABC_KpsT_Wzt; 1.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR015860; ABC_transpr_TagH-like.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF01476; LysM; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00257; LysM; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54106; SSF54106; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS51782; LYSM; 1.
DR PROSITE; PS51251; TAGH; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cell membrane; Membrane; Nucleotide-binding;
KW Reference proteome; Translocase; Transport.
FT CHAIN 1..466
FT /note="Teichoic acids export ATP-binding protein TagH"
FT /id="PRO_0000092990"
FT DOMAIN 27..249
FT /note="ABC transporter"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01715"
FT DOMAIN 403..447
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT REGION 250..466
FT /note="Unknown"
FT REGION 356..403
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 439..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 63..70
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01715"
SQ SEQUENCE 466 AA; 52210 MW; 3A35DCD621656C48 CRC64;
MNTNKVKIKA EYLTKKFELL PAKSSKNKAK SLIGSNSKNE KDFWALRNIS FEIRDGECVG
VIGLNGAGKS TLSNIISGQI AQTTGRVEIN GDVSIIAASA GMQNNLSGRE NIRLKALMVG
LTNKEIKSKM DDIIEFSELG PFIDQPVKTY SSGMKAKLGF SIMVHQNPDI MIIDEGLSVG
DKTFVDKSQK KMFEFRDEGK TILLVSHDMR TIKEWCDRVI WLNYGEVKAY GRPEEVIPEY
EKFVQWFKKL PKKEQEKFKT DQRQAQLDYS VEELKAEIVS QNPSKSRRVQ REVTEELKNK
KDNHKLSLMS KVIVWLCLLA FIWITLVSLS NATLAESLRH PKTFFTERLF KSDTRNMTST
TKKEAVVKTS SSPKKKVSQA KKTTKVSSTQ KNTSSSSSTS NQNTYIVQAG DSLSIIAENH
GYSVEEIQQV NPGVDFSVIH PGQEINLPEP TTSANSTTEQ SDGANQ