ID   TAGL2_RAT               Reviewed;         199 AA.
AC   Q5XFX0;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Transgelin-2;
GN   Name=Tagln2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
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DR   EMBL; BC084703; AAH84703.1; -; mRNA.
DR   RefSeq; NP_001013145.1; NM_001013127.1.
DR   RefSeq; XP_006250357.1; XM_006250295.2.
DR   AlphaFoldDB; Q5XFX0; -.
DR   SMR; Q5XFX0; -.
DR   IntAct; Q5XFX0; 3.
DR   MINT; Q5XFX0; -.
DR   STRING; 10116.ENSRNOP00000011208; -.
DR   iPTMnet; Q5XFX0; -.
DR   PhosphoSitePlus; Q5XFX0; -.
DR   SwissPalm; Q5XFX0; -.
DR   jPOST; Q5XFX0; -.
DR   PaxDb; Q5XFX0; -.
DR   PRIDE; Q5XFX0; -.
DR   Ensembl; ENSRNOT00000011208; ENSRNOP00000011208; ENSRNOG00000008301.
DR   GeneID; 304983; -.
DR   KEGG; rno:304983; -.
DR   UCSC; RGD:1310840; rat.
DR   CTD; 8407; -.
DR   RGD; 1310840; Tagln2.
DR   eggNOG; KOG2046; Eukaryota.
DR   GeneTree; ENSGT00940000158886; -.
DR   HOGENOM; CLU_055232_1_0_1; -.
DR   InParanoid; Q5XFX0; -.
DR   OMA; IQWITSQ; -.
DR   OrthoDB; 861989at2759; -.
DR   PhylomeDB; Q5XFX0; -.
DR   TreeFam; TF313921; -.
DR   PRO; PR:Q5XFX0; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000008301; Expressed in lung and 19 other tissues.
DR   Genevisible; Q5XFX0; RN.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030855; P:epithelial cell differentiation; ISO:RGD.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR000557; Calponin_repeat.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR003096; SM22_calponin.
DR   InterPro; IPR001061; TAGLN2.
DR   PANTHER; PTHR18959:SF41; PTHR18959:SF41; 1.
DR   Pfam; PF00402; Calponin; 1.
DR   Pfam; PF00307; CH; 1.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS01052; CALPONIN_1; 1.
DR   PROSITE; PS51122; CALPONIN_2; 1.
DR   PROSITE; PS50021; CH; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Isopeptide bond; Methylation; Phosphoprotein;
KW   Reference proteome; Ubl conjugation.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   CHAIN           2..199
FT                   /note="Transgelin-2"
FT                   /id="PRO_0000355991"
FT   DOMAIN          24..136
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REPEAT          174..199
FT                   /note="Calponin-like"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   MOD_RES         11
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   MOD_RES         17
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   MOD_RES         20
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         180
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   MOD_RES         182
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   MOD_RES         196
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
FT   CROSSLNK        171
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P37802"
SQ   SEQUENCE   199 AA;  22393 MW;  5BDAAA283E4BDDEE CRC64;
     MANRGPSYGL SREVQQKIEK QYDPDLEQIL IQWITTQCRK GVSQPQPGRE NFQNWLKDGT
     VLCELINSLY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK
     NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT
     NRGASQAGMT GYGMPRQIL