TAGL3_HUMAN
ID TAGL3_HUMAN Reviewed; 199 AA.
AC Q9UI15; D3DN64; Q96A74;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 15-AUG-2003, sequence version 2.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Transgelin-3;
DE AltName: Full=Neuronal protein 22;
DE Short=NP22;
DE AltName: Full=Neuronal protein NP25;
GN Name=TAGLN3; Synonyms=NP25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Brain;
RX PubMed=11238712; DOI=10.1046/j.1471-4159.2001.00176.x;
RA Fan L., Jaquet V., Dodd P.R., Chen W., Wilce P.A.;
RT "Molecular cloning and characterization of hNP22: a gene up-regulated in
RT human alcoholic brain.";
RL J. Neurochem. 76:1275-1281(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hypothalamus;
RX PubMed=10931946; DOI=10.1073/pnas.160270997;
RA Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X.,
RA Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W.,
RA Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M., Zhou J., Xu S.-H., Gu J.,
RA Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z.,
RA Chen M.-D., Chen J.-L.;
RT "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis
RT and full-length cDNA cloning.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA Phelan M., Farmer A.;
RT "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP PROTEIN SEQUENCE OF 5-12; 22-49; 55-79; 89-120; 128-139; 146-153 AND
RP 160-196, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Brain, Cajal-Retzius cell, and Fetal brain cortex;
RA Lubec G., Afjehi-Sadat L., Chen W.-Q., Sun Y.;
RL Submitted (DEC-2008) to UniProtKB.
CC -!- TISSUE SPECIFICITY: Widely expressed in the brain. Expression is
CC increased in the superior frontal cortex of alcoholics, but not in the
CC motor cortex or cerebellum.
CC -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF17189.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF303058; AAL09330.1; -; mRNA.
DR EMBL; AF112201; AAF17189.1; ALT_FRAME; mRNA.
DR EMBL; BT007408; AAP36076.1; -; mRNA.
DR EMBL; CH471052; EAW79685.1; -; Genomic_DNA.
DR EMBL; CH471052; EAW79686.1; -; Genomic_DNA.
DR EMBL; BC015329; AAH15329.1; -; mRNA.
DR CCDS; CCDS33816.1; -.
DR RefSeq; NP_001008273.1; NM_001008272.1.
DR RefSeq; NP_001008274.1; NM_001008273.1.
DR RefSeq; NP_037391.2; NM_013259.2.
DR AlphaFoldDB; Q9UI15; -.
DR SMR; Q9UI15; -.
DR BioGRID; 118880; 37.
DR IntAct; Q9UI15; 1.
DR STRING; 9606.ENSP00000377494; -.
DR iPTMnet; Q9UI15; -.
DR PhosphoSitePlus; Q9UI15; -.
DR BioMuta; TAGLN3; -.
DR DMDM; 33860182; -.
DR UCD-2DPAGE; Q9UI15; -.
DR EPD; Q9UI15; -.
DR jPOST; Q9UI15; -.
DR MassIVE; Q9UI15; -.
DR MaxQB; Q9UI15; -.
DR PaxDb; Q9UI15; -.
DR PeptideAtlas; Q9UI15; -.
DR PRIDE; Q9UI15; -.
DR ProteomicsDB; 84454; -.
DR Antibodypedia; 32456; 163 antibodies from 23 providers.
DR DNASU; 29114; -.
DR Ensembl; ENST00000273368.8; ENSP00000273368.4; ENSG00000144834.14.
DR Ensembl; ENST00000393917.6; ENSP00000377494.2; ENSG00000144834.14.
DR Ensembl; ENST00000455401.6; ENSP00000391160.2; ENSG00000144834.14.
DR Ensembl; ENST00000478951.6; ENSP00000419105.1; ENSG00000144834.14.
DR GeneID; 29114; -.
DR KEGG; hsa:29114; -.
DR MANE-Select; ENST00000478951.6; ENSP00000419105.1; NM_001008272.2; NP_001008273.1.
DR UCSC; uc003dyl.4; human.
DR CTD; 29114; -.
DR DisGeNET; 29114; -.
DR GeneCards; TAGLN3; -.
DR HGNC; HGNC:29868; TAGLN3.
DR HPA; ENSG00000144834; Tissue enhanced (brain, choroid plexus, pituitary gland).
DR MIM; 607953; gene.
DR neXtProt; NX_Q9UI15; -.
DR OpenTargets; ENSG00000144834; -.
DR PharmGKB; PA134896732; -.
DR VEuPathDB; HostDB:ENSG00000144834; -.
DR eggNOG; KOG2046; Eukaryota.
DR GeneTree; ENSGT00940000159385; -.
DR HOGENOM; CLU_055232_1_0_1; -.
DR InParanoid; Q9UI15; -.
DR OMA; EYGYMKG; -.
DR OrthoDB; 861989at2759; -.
DR PhylomeDB; Q9UI15; -.
DR TreeFam; TF313921; -.
DR PathwayCommons; Q9UI15; -.
DR SignaLink; Q9UI15; -.
DR BioGRID-ORCS; 29114; 11 hits in 1066 CRISPR screens.
DR ChiTaRS; TAGLN3; human.
DR GeneWiki; TAGLN3; -.
DR GenomeRNAi; 29114; -.
DR Pharos; Q9UI15; Tbio.
DR PRO; PR:Q9UI15; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9UI15; protein.
DR Bgee; ENSG00000144834; Expressed in frontal pole and 140 other tissues.
DR ExpressionAtlas; Q9UI15; baseline and differential.
DR Genevisible; Q9UI15; HS.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0007417; P:central nervous system development; TAS:ProtInc.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR029973; TAGLN3.
DR PANTHER; PTHR18959:SF57; PTHR18959:SF57; 1.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..199
FT /note="Transgelin-3"
FT /id="PRO_0000204788"
FT DOMAIN 24..136
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 174..199
FT /note="Calponin-like"
FT REGION 176..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P37805"
SQ SEQUENCE 199 AA; 22473 MW; 09837A0CC2A0E157 CRC64;
MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT
VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA ETYGVRTTDI FQTVDLWEGK
DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS
NKGASQAGMT GYGMPRQIM
