TAGL3_MOUSE
ID TAGL3_MOUSE Reviewed; 199 AA.
AC Q9R1Q8;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Transgelin-3;
DE AltName: Full=Neuronal protein NP25;
GN Name=Tagln3; Synonyms=Np25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Hayashi A., Hattori A., Okaze H., Kozuma S., Seki N., Saito T.;
RT "Mouse neuronal protein (NP25).";
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PROTEIN SEQUENCE OF 30-49 AND 65-79, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RC TISSUE=Hippocampus;
RA Lubec G., Klug S.;
RL Submitted (MAR-2007) to UniProtKB.
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
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DR EMBL; AB031291; BAA83499.1; -; mRNA.
DR EMBL; BC043027; AAH43027.1; -; mRNA.
DR EMBL; BC055338; AAH55338.1; -; mRNA.
DR CCDS; CCDS28200.1; -.
DR RefSeq; NP_062728.1; NM_019754.3.
DR AlphaFoldDB; Q9R1Q8; -.
DR SMR; Q9R1Q8; -.
DR BioGRID; 207932; 4.
DR IntAct; Q9R1Q8; 2.
DR STRING; 10090.ENSMUSP00000093762; -.
DR iPTMnet; Q9R1Q8; -.
DR PhosphoSitePlus; Q9R1Q8; -.
DR EPD; Q9R1Q8; -.
DR jPOST; Q9R1Q8; -.
DR MaxQB; Q9R1Q8; -.
DR PaxDb; Q9R1Q8; -.
DR PeptideAtlas; Q9R1Q8; -.
DR PRIDE; Q9R1Q8; -.
DR ProteomicsDB; 262999; -.
DR Antibodypedia; 32456; 163 antibodies from 23 providers.
DR DNASU; 56370; -.
DR Ensembl; ENSMUST00000096057; ENSMUSP00000093762; ENSMUSG00000022658.
DR GeneID; 56370; -.
DR KEGG; mmu:56370; -.
DR UCSC; uc007ziw.1; mouse.
DR CTD; 29114; -.
DR MGI; MGI:1926784; Tagln3.
DR VEuPathDB; HostDB:ENSMUSG00000022658; -.
DR eggNOG; KOG2046; Eukaryota.
DR GeneTree; ENSGT00940000159385; -.
DR HOGENOM; CLU_055232_1_0_1; -.
DR InParanoid; Q9R1Q8; -.
DR OMA; EYGYMKG; -.
DR OrthoDB; 861989at2759; -.
DR PhylomeDB; Q9R1Q8; -.
DR TreeFam; TF313921; -.
DR BioGRID-ORCS; 56370; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Tagln3; mouse.
DR PRO; PR:Q9R1Q8; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9R1Q8; protein.
DR Bgee; ENSMUSG00000022658; Expressed in dentate gyrus of hippocampal formation granule cell and 184 other tissues.
DR Genevisible; Q9R1Q8; MM.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0043209; C:myelin sheath; HDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:MGI.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR029973; TAGLN3.
DR PANTHER; PTHR18959:SF57; PTHR18959:SF57; 1.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..199
FT /note="Transgelin-3"
FT /id="PRO_0000204789"
FT DOMAIN 24..136
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 174..199
FT /note="Calponin-like"
FT REGION 178..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P37805"
SQ SEQUENCE 199 AA; 22471 MW; 53802F6F94958202 CRC64;
MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRA HFQKWLMDGT
VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA EVYGVRTTDI FQTVDLWEGK
DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS
NKGASQAGMT GYGMPRQIM
