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TAGL3_RAT
ID   TAGL3_RAT               Reviewed;         199 AA.
AC   P37805; Q09025; Q8VHH3;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 147.
DE   RecName: Full=Transgelin-3;
DE   AltName: Full=Neuronal protein 22;
DE            Short=NP22;
DE   AltName: Full=Neuronal protein NP25;
GN   Name=Tagln3; Synonyms=Np25;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=8015377; DOI=10.1016/0169-328x(94)90045-0;
RA   Ren W.-Z., Ng G.Y.K., Wang R.-X., Wu P.H., O'Dowd B.F., Osmond D.H.,
RA   George S.R., Liew C.-C.;
RT   "The identification of NP25: a novel protein that is differentially
RT   expressed by neuronal subpopulations.";
RL   Brain Res. Mol. Brain Res. 22:173-185(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RA   Wilce P.A., Jaquet V., Bursle J.K., Fan L., Depaz I.M., van der Brug M.P.,
RA   de las Heras R.;
RL   Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   PROTEIN SEQUENCE OF 30-49; 65-79; 89-98; 128-139 AND 160-168, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Brain, Hippocampus, and Spinal cord;
RA   Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.;
RL   Submitted (JUL-2007) to UniProtKB.
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- TISSUE SPECIFICITY: Abundant and ubiquitous expression in neurons.
CC   -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC42095.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; M84725; AAC42095.1; ALT_FRAME; mRNA.
DR   EMBL; AF459788; AAL66341.1; -; mRNA.
DR   PIR; I52644; I52644.
DR   RefSeq; NP_001030313.1; NM_001035236.1.
DR   RefSeq; NP_113864.2; NM_031676.2.
DR   RefSeq; XP_008766898.1; XM_008768676.1.
DR   AlphaFoldDB; P37805; -.
DR   SMR; P37805; -.
DR   BioGRID; 248896; 1.
DR   STRING; 10116.ENSRNOP00000002942; -.
DR   iPTMnet; P37805; -.
DR   PhosphoSitePlus; P37805; -.
DR   SwissPalm; P37805; -.
DR   World-2DPAGE; 0004:P37805; -.
DR   jPOST; P37805; -.
DR   PaxDb; P37805; -.
DR   PRIDE; P37805; -.
DR   Ensembl; ENSRNOT00000090230; ENSRNOP00000072985; ENSRNOG00000064186.
DR   GeneID; 63837; -.
DR   KEGG; rno:63837; -.
DR   UCSC; RGD:69301; rat.
DR   CTD; 29114; -.
DR   RGD; 69301; Tagln3.
DR   eggNOG; KOG2046; Eukaryota.
DR   GeneTree; ENSGT00940000159385; -.
DR   HOGENOM; CLU_055232_1_0_1; -.
DR   InParanoid; P37805; -.
DR   OMA; EYGYMKG; -.
DR   OrthoDB; 861989at2759; -.
DR   PhylomeDB; P37805; -.
DR   TreeFam; TF313921; -.
DR   PRO; PR:P37805; -.
DR   Proteomes; UP000002494; Chromosome 11.
DR   Bgee; ENSRNOG00000002151; Expressed in cerebellum and 4 other tissues.
DR   ExpressionAtlas; P37805; baseline.
DR   Genevisible; P37805; RN.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISO:RGD.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR000557; Calponin_repeat.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR003096; SM22_calponin.
DR   InterPro; IPR029973; TAGLN3.
DR   PANTHER; PTHR18959:SF57; PTHR18959:SF57; 1.
DR   Pfam; PF00402; Calponin; 1.
DR   Pfam; PF00307; CH; 1.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS01052; CALPONIN_1; 1.
DR   PROSITE; PS51122; CALPONIN_2; 1.
DR   PROSITE; PS50021; CH; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..199
FT                   /note="Transgelin-3"
FT                   /id="PRO_0000204790"
FT   DOMAIN          24..136
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REPEAT          174..199
FT                   /note="Calponin-like"
FT   REGION          178..199
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         163
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   199 AA;  22501 MW;  52C52F7BC5DFD2EC CRC64;
     MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRT HFQKWLMDGT
     VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA EVYGVRTTDI FQTVDLWEGK
     DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS
     NKGASQAGMT GYGMPRQIM
 
 
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