TAGL3_RAT
ID TAGL3_RAT Reviewed; 199 AA.
AC P37805; Q09025; Q8VHH3;
DT 01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Transgelin-3;
DE AltName: Full=Neuronal protein 22;
DE Short=NP22;
DE AltName: Full=Neuronal protein NP25;
GN Name=Tagln3; Synonyms=Np25;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=8015377; DOI=10.1016/0169-328x(94)90045-0;
RA Ren W.-Z., Ng G.Y.K., Wang R.-X., Wu P.H., O'Dowd B.F., Osmond D.H.,
RA George S.R., Liew C.-C.;
RT "The identification of NP25: a novel protein that is differentially
RT expressed by neuronal subpopulations.";
RL Brain Res. Mol. Brain Res. 22:173-185(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RA Wilce P.A., Jaquet V., Bursle J.K., Fan L., Depaz I.M., van der Brug M.P.,
RA de las Heras R.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PROTEIN SEQUENCE OF 30-49; 65-79; 89-98; 128-139 AND 160-168, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=Sprague-Dawley; TISSUE=Brain, Hippocampus, and Spinal cord;
RA Lubec G., Afjehi-Sadat L., Chen W.-Q., Kang S.U.;
RL Submitted (JUL-2007) to UniProtKB.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=22673903; DOI=10.1038/ncomms1871;
RA Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA Olsen J.V.;
RT "Quantitative maps of protein phosphorylation sites across 14 different rat
RT organs and tissues.";
RL Nat. Commun. 3:876-876(2012).
CC -!- TISSUE SPECIFICITY: Abundant and ubiquitous expression in neurons.
CC -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC42095.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; M84725; AAC42095.1; ALT_FRAME; mRNA.
DR EMBL; AF459788; AAL66341.1; -; mRNA.
DR PIR; I52644; I52644.
DR RefSeq; NP_001030313.1; NM_001035236.1.
DR RefSeq; NP_113864.2; NM_031676.2.
DR RefSeq; XP_008766898.1; XM_008768676.1.
DR AlphaFoldDB; P37805; -.
DR SMR; P37805; -.
DR BioGRID; 248896; 1.
DR STRING; 10116.ENSRNOP00000002942; -.
DR iPTMnet; P37805; -.
DR PhosphoSitePlus; P37805; -.
DR SwissPalm; P37805; -.
DR World-2DPAGE; 0004:P37805; -.
DR jPOST; P37805; -.
DR PaxDb; P37805; -.
DR PRIDE; P37805; -.
DR Ensembl; ENSRNOT00000090230; ENSRNOP00000072985; ENSRNOG00000064186.
DR GeneID; 63837; -.
DR KEGG; rno:63837; -.
DR UCSC; RGD:69301; rat.
DR CTD; 29114; -.
DR RGD; 69301; Tagln3.
DR eggNOG; KOG2046; Eukaryota.
DR GeneTree; ENSGT00940000159385; -.
DR HOGENOM; CLU_055232_1_0_1; -.
DR InParanoid; P37805; -.
DR OMA; EYGYMKG; -.
DR OrthoDB; 861989at2759; -.
DR PhylomeDB; P37805; -.
DR TreeFam; TF313921; -.
DR PRO; PR:P37805; -.
DR Proteomes; UP000002494; Chromosome 11.
DR Bgee; ENSRNOG00000002151; Expressed in cerebellum and 4 other tissues.
DR ExpressionAtlas; P37805; baseline.
DR Genevisible; P37805; RN.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:RGD.
DR CDD; cd00014; CH; 1.
DR Gene3D; 1.10.418.10; -; 1.
DR InterPro; IPR000557; Calponin_repeat.
DR InterPro; IPR001715; CH-domain.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR003096; SM22_calponin.
DR InterPro; IPR029973; TAGLN3.
DR PANTHER; PTHR18959:SF57; PTHR18959:SF57; 1.
DR Pfam; PF00402; Calponin; 1.
DR Pfam; PF00307; CH; 1.
DR PRINTS; PR00888; SM22CALPONIN.
DR SMART; SM00033; CH; 1.
DR SUPFAM; SSF47576; SSF47576; 1.
DR PROSITE; PS01052; CALPONIN_1; 1.
DR PROSITE; PS51122; CALPONIN_2; 1.
DR PROSITE; PS50021; CH; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Phosphoprotein; Reference proteome.
FT CHAIN 1..199
FT /note="Transgelin-3"
FT /id="PRO_0000204790"
FT DOMAIN 24..136
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT REPEAT 174..199
FT /note="Calponin-like"
FT REGION 178..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 163
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:22673903"
SQ SEQUENCE 199 AA; 22501 MW; 52C52F7BC5DFD2EC CRC64;
MANRGPSYGL SREVQEKIEQ KYDADLENKL VDWIILQCAE DIEHPPPGRT HFQKWLMDGT
VLCKLINSLY PPGQEPIPKI SESKMAFKQM EQISQFLKAA EVYGVRTTDI FQTVDLWEGK
DMAAVQRTLM ALGSVAVTKD DGCYRGEPSW FHRKAQQNRR GFSEEQLRQG QNVIGLQMGS
NKGASQAGMT GYGMPRQIM