ID   TAGL_CHICK              Reviewed;         200 AA.
AC   P19966;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Transgelin;
DE   AltName: Full=Smooth muscle protein 22-alpha;
DE            Short=SM22-alpha;
GN   Name=TAGLN; Synonyms=SM22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Gizzard smooth muscle;
RX   PubMed=1872880;
RA   Nishida W., Kitami Y., Abe M., Kiwada K.;
RT   "Gene cloning and nucleotide sequence of SM22 alpha from the chicken
RT   gizzard smooth muscle.";
RL   Biochem. Int. 23:663-668(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-198, AND ACETYLATION AT ALA-2.
RC   TISSUE=Gizzard smooth muscle;
RX   PubMed=3571244; DOI=10.1016/s0021-9258(18)45526-3;
RA   Pearlstone J.R., Weber M., Lees-Miller J.P., Carpenter M.R., Smillie L.B.;
RT   "Amino acid sequence of chicken gizzard smooth muscle SM22 alpha.";
RL   J. Biol. Chem. 262:5985-5991(1987).
CC   -!- FUNCTION: Actin cross-linking/gelling protein. {ECO:0000250}.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Gizzard, uterus, intestine, esophagus, aorta, and
CC       trace amounts in brain, liver and heart.
CC   -!- SIMILARITY: Belongs to the calponin family. {ECO:0000305}.
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DR   EMBL; M83105; AAA48782.1; -; mRNA.
DR   PIR; I50236; A26694.
DR   RefSeq; NP_990825.1; NM_205494.1.
DR   RefSeq; XP_015153456.1; XM_015297970.1.
DR   AlphaFoldDB; P19966; -.
DR   SMR; P19966; -.
DR   STRING; 9031.ENSGALP00000019399; -.
DR   iPTMnet; P19966; -.
DR   PaxDb; P19966; -.
DR   Ensembl; ENSGALT00000019425; ENSGALP00000019399; ENSGALG00000011902.
DR   GeneID; 396490; -.
DR   KEGG; gga:396490; -.
DR   CTD; 6876; -.
DR   VEuPathDB; HostDB:geneid_396490; -.
DR   eggNOG; KOG2046; Eukaryota.
DR   GeneTree; ENSGT00940000155162; -.
DR   HOGENOM; CLU_055232_1_0_1; -.
DR   InParanoid; P19966; -.
DR   OMA; AYKHPEW; -.
DR   OrthoDB; 861989at2759; -.
DR   PhylomeDB; P19966; -.
DR   PRO; PR:P19966; -.
DR   Proteomes; UP000000539; Chromosome 24.
DR   Bgee; ENSGALG00000011902; Expressed in colon and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR   GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR   CDD; cd00014; CH; 1.
DR   Gene3D; 1.10.418.10; -; 1.
DR   InterPro; IPR000557; Calponin_repeat.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR036872; CH_dom_sf.
DR   InterPro; IPR003096; SM22_calponin.
DR   InterPro; IPR029976; TAGLN.
DR   PANTHER; PTHR18959:SF40; PTHR18959:SF40; 1.
DR   Pfam; PF00402; Calponin; 1.
DR   Pfam; PF00307; CH; 1.
DR   PRINTS; PR00888; SM22CALPONIN.
DR   SMART; SM00033; CH; 1.
DR   SUPFAM; SSF47576; SSF47576; 1.
DR   PROSITE; PS01052; CALPONIN_1; 1.
DR   PROSITE; PS51122; CALPONIN_2; 1.
DR   PROSITE; PS50021; CH; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Cytoplasm; Direct protein sequencing; Muscle protein;
KW   Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:3571244"
FT   CHAIN           2..200
FT                   /note="Transgelin"
FT                   /id="PRO_0000204784"
FT   DOMAIN          24..137
FT                   /note="Calponin-homology (CH)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00044"
FT   REPEAT          175..199
FT                   /note="Calponin-like"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:3571244"
SQ   SEQUENCE   200 AA;  22315 MW;  8F6207336ED5AAC9 CRC64;
     MANKGPAYGM SRDVQSKIEK KYDDELEDRL VEWIVAQCGS SVGRPDRGRL GFQVWLKNGI
     VLSQLVNSLY PDGSKPVKIP DSPPTMVFKQ MEQIAQFLKA AEDYGVVKTD MFQTVDLFEA
     KDMAAVQRTL VALGSLAVTK NDGHYHGDPN WFMKKAQEHK REFSESQLKE GKNIIGLQMG
     TNKGASQAGM SYGRPRQIIS