ID   ABTB2_RAT               Reviewed;        1009 AA.
AC   O08764;
DT   01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 125.
DE   RecName: Full=Ankyrin repeat and BTB/POZ domain-containing protein 2;
DE   AltName: Full=CCA3;
DE   AltName: Full=Confluent 3Y1 cell-associated protein;
GN   Name=Abtb2; Synonyms=Cca3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Fibroblast;
RX   PubMed=9109406; DOI=10.1016/s0014-5793(97)00258-5;
RA   Hayashi Y., Ichinose M., Yuasa H., Tatematsu M., Ishibashi M.;
RT   "Cca3, the mRNA level of which transiently decreases before initiation of
RT   DNA synthesis in regenerating rat liver cells.";
RL   FEBS Lett. 406:147-150(1997).
CC   -!- FUNCTION: May be involved in the initiation of hepatocyte growth.
CC   -!- TISSUE SPECIFICITY: Highly expressed in liver, brain and testis with
CC       lower expression in the spleen. {ECO:0000269|PubMed:9109406}.
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DR   EMBL; AB000216; BAA19969.1; -; mRNA.
DR   PIR; T31081; T31081.
DR   RefSeq; NP_599230.2; NM_134403.2.
DR   AlphaFoldDB; O08764; -.
DR   SMR; O08764; -.
DR   STRING; 10116.ENSRNOP00000038218; -.
DR   PaxDb; O08764; -.
DR   GeneID; 171440; -.
DR   KEGG; rno:171440; -.
DR   UCSC; RGD:620724; rat.
DR   CTD; 25841; -.
DR   RGD; 620724; Abtb2.
DR   eggNOG; ENOG502QSQY; Eukaryota.
DR   InParanoid; O08764; -.
DR   OrthoDB; 416322at2759; -.
DR   PhylomeDB; O08764; -.
DR   PRO; PR:O08764; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0097237; P:cellular response to toxic substance; ISO:RGD.
DR   Gene3D; 1.10.20.10; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF00023; Ank; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00651; BTB; 1.
DR   SMART; SM00248; ANK; 5.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF47113; SSF47113; 2.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 3.
DR   PROSITE; PS50097; BTB; 1.
PE   2: Evidence at transcript level;
KW   ANK repeat; Reference proteome; Repeat.
FT   CHAIN           1..1009
FT                   /note="Ankyrin repeat and BTB/POZ domain-containing protein
FT                   2"
FT                   /id="PRO_0000066889"
FT   REPEAT          520..549
FT                   /note="ANK 1"
FT   REPEAT          566..595
FT                   /note="ANK 2"
FT   REPEAT          605..634
FT                   /note="ANK 3"
FT   REPEAT          648..677
FT                   /note="ANK 4"
FT   DOMAIN          843..912
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   1009 AA;  111603 MW;  E25CE5BA846510FA CRC64;
     MAGTYSSTLK TLEDLTLDSG YGAGDSCRSL SLSSSKSNSQ ALNSSAPQHR GAAWWCYSGS
     MNSRHNSWDT VNTVLPEDPE VADLFSRCPR LPELEEFPWT EGDVARVLRK SVGGRRLPSF
     SAEAVRRLAG LLRRALIRVA REAQRLSVLH AKCTRFEVQS AVRLVHSWAL AESCALAAVK
     ALSLYSMSAG DGLRRGKSAR CGLTFSVGRF FRWMVDTRIS VRIHEYAAIS LTACMENLVE
     EIRARVLASQ SPDGGGAGGG EVSAEALEMV INNDAELWGV LQPYEHLICG KNANGVLSLP
     AYFSPYNGGS LGHDERADAY AQLELRTLEQ SLLATCVGSI SELSDLVSRA MHHMQGRHPL
     CPGTSPARQA RQPPQPITWS PDALHTLYYF LRCPQMESME NPNLDPPRMT LNNERPFMLL
     PPLMEWMRVA ITYAEHRRSL TVDSGDIRQA ARLLLPGLDC EPRQLKPECC FSSFRRLDAR
     AATERFNQDL GFRMLNCGRT DLISQPSSPG PDGVNTMDDQ GLTPLMYACA TGDEAMVQML
     IDAGANLDIQ VPSNSPRHPS VHPDSRHWTS LTFAVLHGHI SVVQLLLDAG AHVEGSAVNS
     GEDSYAETPL QLASAAGNYE LVSLLLSRGA DPLLSMLEAN GMASSLHEDM NCFSHSAAHG
     HRNVLRKLLT QPQQAKADVL SLEEILAEGV EESDTSSQGS SEGPVRLSRT RTKALQEAMY
     YSAEHGYVDI TMELRALGVP WKLHIWIESL RTSFSQSRYS VVQGLLRDFS SIKEEEYNEE
     LVTEGLQLMF DILKTSKNDS VLQQLATIFT HCYGTSPIPS IPEIRKTLPA RLDPHFLNNK
     EMSDVTFLVE GKLFYAHKVL LVTASNRFKT LMTNKSEQDG DNSKTIEISD IKYHIFQMLM
     QYLYYGGTES MEIPTADILQ LLSAANLFQL DALQRHCEIL CSQTLSVESA VNTYKYAKIH
     NAPELALFCE GFFLKHMKAL LEQMPSGSSS MAEAAKSRAW THCRICRAP