ID   TAGPE_AGRFC             Reviewed;         425 AA.
AC   A9CES6;
DT   10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=D-tagatose 6-phosphate 4-epimerase {ECO:0000305};
DE            EC=5.1.3.40 {ECO:0000269|PubMed:26472925};
GN   OrderedLocusNames=Atu3167 {ECO:0000312|EMBL:AAK90219.1};
OS   Agrobacterium fabrum (strain C58 / ATCC 33970) (Agrobacterium tumefaciens
OS   (strain C58)).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Rhizobiaceae; Rhizobium/Agrobacterium group; Agrobacterium;
OC   Agrobacterium tumefaciens complex.
OX   NCBI_TaxID=176299;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743193; DOI=10.1126/science.1066804;
RA   Wood D.W., Setubal J.C., Kaul R., Monks D.E., Kitajima J.P., Okura V.K.,
RA   Zhou Y., Chen L., Wood G.E., Almeida N.F. Jr., Woo L., Chen Y.,
RA   Paulsen I.T., Eisen J.A., Karp P.D., Bovee D. Sr., Chapman P.,
RA   Clendenning J., Deatherage G., Gillet W., Grant C., Kutyavin T., Levy R.,
RA   Li M.-J., McClelland E., Palmieri A., Raymond C., Rouse G.,
RA   Saenphimmachak C., Wu Z., Romero P., Gordon D., Zhang S., Yoo H., Tao Y.,
RA   Biddle P., Jung M., Krespan W., Perry M., Gordon-Kamm B., Liao L., Kim S.,
RA   Hendrick C., Zhao Z.-Y., Dolan M., Chumley F., Tingey S.V., Tomb J.-F.,
RA   Gordon M.P., Olson M.V., Nester E.W.;
RT   "The genome of the natural genetic engineer Agrobacterium tumefaciens
RT   C58.";
RL   Science 294:2317-2323(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=11743194; DOI=10.1126/science.1066803;
RA   Goodner B., Hinkle G., Gattung S., Miller N., Blanchard M., Qurollo B.,
RA   Goldman B.S., Cao Y., Askenazi M., Halling C., Mullin L., Houmiel K.,
RA   Gordon J., Vaudin M., Iartchouk O., Epp A., Liu F., Wollam C., Allinger M.,
RA   Doughty D., Scott C., Lappas C., Markelz B., Flanagan C., Crowell C.,
RA   Gurson J., Lomo C., Sear C., Strub G., Cielo C., Slater S.;
RT   "Genome sequence of the plant pathogen and biotechnology agent
RT   Agrobacterium tumefaciens C58.";
RL   Science 294:2323-2328(2001).
RN   [3]
RP   FUNCTION, CATALYTIC ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, PATHWAY,
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=C58 / ATCC 33970;
RX   PubMed=26472925; DOI=10.1074/jbc.m115.686857;
RA   Wichelecki D.J., Vetting M.W., Chou L., Al-Obaidi N., Bouvier J.T.,
RA   Almo S.C., Gerlt J.A.;
RT   "ATP-binding cassette (ABC) transport system solute-binding protein-guided
RT   identification of novel D-altritol and galactitol catabolic pathways in
RT   Agrobacterium tumefaciens C58.";
RL   J. Biol. Chem. 290:28963-28976(2015).
CC   -!- FUNCTION: Involved in galactitol and D-altritol catabolism. Catalyzes
CC       the epimerization of D-tagatose 6-phosphate to D-fructose 6-phosphate.
CC       {ECO:0000269|PubMed:26472925}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=keto-D-tagatose 6-phosphate = keto-D-fructose 6-phosphate;
CC         Xref=Rhea:RHEA:51712, ChEBI:CHEBI:57579, ChEBI:CHEBI:134283;
CC         EC=5.1.3.40; Evidence={ECO:0000269|PubMed:26472925};
CC   -!- BIOPHYSICOCHEMICAL PROPERTIES:
CC       Kinetic parameters:
CC         KM=0.98 mM for D-tagatose 6-phosphate {ECO:0000269|PubMed:26472925};
CC         Note=kcat is 8.7 sec(-1). {ECO:0000269|PubMed:26472925};
CC   -!- PATHWAY: Carbohydrate metabolism. {ECO:0000269|PubMed:26472925}.
CC   -!- INDUCTION: Up-regulated by growth on D-altritol or galactitol.
CC       {ECO:0000269|PubMed:26472925}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene leads to slow-growth
CC       phenotypes for both D-galactitol and D-altritol.
CC       {ECO:0000269|PubMed:26472925}.
CC   -!- SIMILARITY: Belongs to the GatZ/KbaZ family. {ECO:0000305}.
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DR   EMBL; AE007870; AAK90219.1; -; Genomic_DNA.
DR   PIR; A98337; A98337.
DR   PIR; AI2945; AI2945.
DR   RefSeq; NP_357434.1; NC_003063.2.
DR   RefSeq; WP_010972812.1; NC_003063.2.
DR   AlphaFoldDB; A9CES6; -.
DR   SMR; A9CES6; -.
DR   STRING; 176299.Atu3167; -.
DR   EnsemblBacteria; AAK90219; AAK90219; Atu3167.
DR   GeneID; 66223485; -.
DR   KEGG; atu:Atu3167; -.
DR   PATRIC; fig|176299.10.peg.3012; -.
DR   eggNOG; COG4573; Bacteria.
DR   HOGENOM; CLU_053334_0_0_5; -.
DR   OMA; AINAVHV; -.
DR   PhylomeDB; A9CES6; -.
DR   BioCyc; AGRO:ATU3167-MON; -.
DR   BioCyc; MetaCyc:MON-20149; -.
DR   Proteomes; UP000000813; Chromosome linear.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR012062; GatZ/KbaZ-like.
DR   Pfam; PF08013; GatZ_KbaZ-like; 1.
DR   PIRSF; PIRSF009264; TagBP_ald_AgaZ; 1.
DR   TIGRFAMs; TIGR02810; agaZ_gatZ; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Isomerase; Reference proteome.
FT   CHAIN           1..425
FT                   /note="D-tagatose 6-phosphate 4-epimerase"
FT                   /id="PRO_0000446637"
SQ   SEQUENCE   425 AA;  45530 MW;  2503DFA345E3AA0C CRC64;
     MTAILENLAA ARRAGKPAGI TSVCSAHPVV LRAAIRRAAA SQTAVLIEAT CNQVNHLGGY
     TGMTPRDFVA FVNSIAAEEG LPAELLIFGG DHLGPNPWRR EKAEDALTKA AAMVDAYVTA
     GFRKIHLDAS MGCAGEPAAL DDVTIAHRAA KLTAVAEKAA TEAGLPKPLY ILGTEVPVPG
     GADHVLETVA PTEPQAARNT IDLHREIFAQ HGLSDAFERV IAFVVQPGVE FGSDNVVAYD
     PQAAQSLSAV LDGEPRLVFE AHSTDYQTEP ALAALVRDGY PILKVGPGLT FAYREALYAL
     DMIASEMVGT YGDRPLARTM EKLMLSAPGD WQGHYHGDDI TLRLQRHYSY SDRIRYYWTR
     PEALAAVSTL HKALDGKTIP ETLLRQYLGE LPLAAVAGKE PEEVLVAAVD QVLATYHAAT
     GEGRH