TAKT_DROME
ID TAKT_DROME Reviewed; 249 AA.
AC Q9VBV3; Q8MR66; Q9VBV2;
DT 29-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Protein takeout;
DE Flags: Precursor;
GN Name=to; ORFNames=CG11853;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000312|EMBL:AAF79960.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE, FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=Canton-S {ECO:0000269|PubMed:10958689};
RC TISSUE=Head {ECO:0000269|PubMed:10958689};
RX PubMed=10958689; DOI=10.1128/mcb.20.18.6935-6944.2000;
RA So W.V., Sarov-Blat L., Kotarski C.K., McDonald M.J., Allada R.,
RA Rosbash M.;
RT "takeout, a novel Drosophila gene under circadian clock transcriptional
RT regulation.";
RL Mol. Cell. Biol. 20:6935-6944(2000).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:12537569};
RC TISSUE=Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=Canton-S {ECO:0000269|PubMed:10892651};
RX PubMed=10892651; DOI=10.1016/s0092-8674(00)80876-4;
RA Sarov-Blat L., So W.V., Liu L., Rosbash M.;
RT "The Drosophila takeout gene is a novel molecular link between circadian
RT rhythms and feeding behavior.";
RL Cell 101:647-656(2000).
RN [6] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND INDUCTION.
RC STRAIN=Canton-S {ECO:0000269|PubMed:12435630};
RX PubMed=12435630; DOI=10.1101/gad.1010302;
RA Dauwalder B., Tsujimoto S., Moss J., Mattox W.;
RT "The Drosophila takeout gene is regulated by the somatic sex-determination
RT pathway and affects male courtship behavior.";
RL Genes Dev. 16:2879-2892(2002).
CC -!- FUNCTION: Participates in a novel circadian output pathway that conveys
CC temporal and food status information to feeding-relevant metabolisms
CC and activities. Involved in male courtship behavior. In the brain-
CC associated fat body, transcription is enhanced by the dsx and fru male-
CC specific isoforms and repressed by the dsx female-specific isoform.
CC {ECO:0000269|PubMed:10892651, ECO:0000269|PubMed:10958689,
CC ECO:0000269|PubMed:12435630}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10892651}.
CC -!- TISSUE SPECIFICITY: Expression is largely restricted to head, with
CC limited expression detectable in cardia and crop. In entrained
CC individuals, expression is observed in the brain cortex (region between
CC optic lobe and central complex), photoreceptors and antennae. In
CC asynchronous individuals, expression is seen in third antennal segment
CC and male-specific expression is seen in the brain-associated fat body.
CC {ECO:0000269|PubMed:10892651, ECO:0000269|PubMed:10958689,
CC ECO:0000269|PubMed:12435630}.
CC -!- INDUCTION: Starvation and circadian clock. In the heads of entrained
CC flies, levels fluctuate daily and the cycle phase is delayed with
CC respect to per and tim. Cycling appears to be linked to the endogenous
CC clock rather than light stimuli. {ECO:0000269|PubMed:10892651,
CC ECO:0000269|PubMed:10958689, ECO:0000269|PubMed:12435630,
CC ECO:0000303|PubMed:10958689}.
CC -!- SIMILARITY: Belongs to the TO family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM52608.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF261748; AAF79960.1; -; mRNA.
DR EMBL; AE014297; AAF56425.2; -; Genomic_DNA.
DR EMBL; AY122096; AAM52608.1; ALT_INIT; mRNA.
DR RefSeq; NP_001287525.1; NM_001300596.1.
DR RefSeq; NP_524497.1; NM_079773.2.
DR AlphaFoldDB; Q9VBV3; -.
DR SMR; Q9VBV3; -.
DR BioGRID; 67955; 1.
DR IntAct; Q9VBV3; 15.
DR STRING; 7227.FBpp0084185; -.
DR PaxDb; Q9VBV3; -.
DR DNASU; 43036; -.
DR EnsemblMetazoa; FBtr0084810; FBpp0084185; FBgn0039298.
DR EnsemblMetazoa; FBtr0339258; FBpp0308365; FBgn0039298.
DR GeneID; 43036; -.
DR KEGG; dme:Dmel_CG11853; -.
DR UCSC; CG11853-RA; d. melanogaster.
DR CTD; 43036; -.
DR FlyBase; FBgn0039298; to.
DR VEuPathDB; VectorBase:FBgn0039298; -.
DR eggNOG; ENOG502SQ21; Eukaryota.
DR GeneTree; ENSGT00530000064246; -.
DR HOGENOM; CLU_069908_0_2_1; -.
DR InParanoid; Q9VBV3; -.
DR OMA; PVAKMNI; -.
DR OrthoDB; 1059730at2759; -.
DR PhylomeDB; Q9VBV3; -.
DR BioGRID-ORCS; 43036; 0 hits in 1 CRISPR screen.
DR ChiTaRS; to; fly.
DR GenomeRNAi; 43036; -.
DR PRO; PR:Q9VBV3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0039298; Expressed in mouthpart and 15 other tissues.
DR ExpressionAtlas; Q9VBV3; baseline and differential.
DR Genevisible; Q9VBV3; DM.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0005615; C:extracellular space; IDA:FlyBase.
DR GO; GO:0008343; P:adult feeding behavior; IMP:FlyBase.
DR GO; GO:0042595; P:behavioral response to starvation; IMP:UniProtKB.
DR GO; GO:0007623; P:circadian rhythm; IEP:FlyBase.
DR GO; GO:0007631; P:feeding behavior; TAS:FlyBase.
DR GO; GO:0008049; P:male courtship behavior; IMP:FlyBase.
DR GO; GO:0007617; P:mating behavior; TAS:FlyBase.
DR GO; GO:0032504; P:multicellular organism reproduction; IBA:GO_Central.
DR GO; GO:0042594; P:response to starvation; TAS:FlyBase.
DR GO; GO:0007622; P:rhythmic behavior; TAS:FlyBase.
DR Gene3D; 3.15.10.30; -; 1.
DR InterPro; IPR010562; Haemolymph_juvenile_hormone-bd.
DR InterPro; IPR038606; To_sf.
DR Pfam; PF06585; JHBP; 1.
DR SMART; SM00700; JHBP; 1.
PE 2: Evidence at transcript level;
KW Behavior; Biological rhythms; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..249
FT /note="Protein takeout"
FT /id="PRO_0000022469"
SQ SEQUENCE 249 AA; 27344 MW; CC3C8634310D5061 CRC64;
MFAIAFAVVL CLLVSVDAKF PEDPKPCKYG DGECIMKLCN TLFSENSAEG DPGLNLMQLD
PLKVDRMVIS QGESSSPVGI TLTFTDNLLY GIKDQRIVKV KGFGRDLTAK HEVKIVTKTF
SLVGPYNIQG KVLILPISGT GQSNMTMVNV RAIVSFSGKP LVKNGETYLD VTDLKITMKP
ESSHYHFSNL FNGDKALGDN MNVFLNENSE AIYKETAKAI DRSFGKLYLG VVKGVFSKLP
YAKFFADES
