ID   TAL1_CHICK              Reviewed;         311 AA.
AC   P24899;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=T-cell acute lymphocytic leukemia protein 1 homolog;
DE            Short=TAL-1;
DE   AltName: Full=Stem cell protein;
GN   Name=TAL1; Synonyms=SCL;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Monoblast;
RX   PubMed=1741264; DOI=10.1093/nar/20.2.368;
RA   Goodwin G.H., Macgregor A., Zhu J., Crompton M.R.;
RT   "Molecular cloning of the chicken SCL cDNA.";
RL   Nucleic Acids Res. 20:368-368(1992).
CC   -!- FUNCTION: Implicated in the genesis of hemopoietic malignancies. It may
CC       play an important role in hemopoietic differentiation.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein. Forms heterodimers with TCF3 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC   -!- PTM: Phosphorylated on serine residues. {ECO:0000250}.
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DR   EMBL; X63371; CAA44971.1; -; mRNA.
DR   PIR; S20085; S20085.
DR   RefSeq; NP_990683.1; NM_205352.1.
DR   AlphaFoldDB; P24899; -.
DR   SMR; P24899; -.
DR   STRING; 9031.ENSGALP00000041680; -.
DR   GeneID; 396298; -.
DR   KEGG; gga:396298; -.
DR   CTD; 6886; -.
DR   VEuPathDB; HostDB:geneid_396298; -.
DR   eggNOG; KOG4029; Eukaryota.
DR   HOGENOM; CLU_1431139_0_0_1; -.
DR   InParanoid; P24899; -.
DR   OrthoDB; 1453623at2759; -.
DR   PhylomeDB; P24899; -.
DR   PRO; PR:P24899; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR040238; TAL-like.
DR   PANTHER; PTHR13864; PTHR13864; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; DNA-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..311
FT                   /note="T-cell acute lymphocytic leukemia protein 1 homolog"
FT                   /id="PRO_0000127435"
FT   DOMAIN          179..231
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..67
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          265..311
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..30
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..279
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..300
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   311 AA;  33768 MW;  85ECD14FF6F3A27B CRC64;
     MTMDRPPAPP PPSSDPRDAR RHDPEADATS EPDSSRGGME PPAEPQLLLN GAAKEAGRPS
     PGPPAAAVPV IELVRRGGSL DIKSREAAGE AMQRAPGAEP CRAAEAACEA RMVQLSPPAL
     PLQPPGRAML YNLGQPLGTI GSGFFGEPDS FSMYGSNRVK RRPSPYEMEI TDGPHTKVVR
     RIFTNSRERW RQQNVNGAFA ELRKLIPTHP PDKKLSKNEI LRLAMKYINF LAKLLNDQEE
     EGNQRGKVNK DSGIVQEDLL QDMLSPNSSC GSSLDGAASP DSFTEEHDTL DSKHARNLHH
     AILPVEGSAQ R