TAL1_TAKRU
ID TAL1_TAKRU Reviewed; 371 AA.
AC Q90YI8;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=T-cell acute lymphocytic leukemia protein 1;
DE Short=TAL-1;
DE AltName: Full=FrSCL;
DE AltName: Full=Stem cell protein;
GN Name=tal1 {ECO:0000250|UniProtKB:O93507};
GN Synonyms=scl {ECO:0000312|EMBL:CAC39451.1};
OS Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX NCBI_TaxID=31033;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAC39451.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=11381108; DOI=10.1073/pnas.101532998;
RA Barton L.M., Goettgens B., Gering M., Gilbert J.G.R., Grafham D.,
RA Rogers J., Bentley D., Patient R.K., Green A.R.;
RT "Regulation of the stem cell leukemia (SCL) gene: a tale of two fishes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:6747-6752(2001).
CC -!- FUNCTION: Transcription factor that plays a pivotal role in hemopoietic
CC and endothelial development. {ECO:0000250|UniProtKB:O93507}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22091,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in the main hemopoietic organs in adults,
CC namely the kidney and the spleen. Also expressed in the liver, brain,
CC gill and gonads. {ECO:0000269|PubMed:11381108}.
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DR EMBL; AJ131019; CAC39451.1; -; Genomic_DNA.
DR AlphaFoldDB; Q90YI8; -.
DR SMR; Q90YI8; -.
DR STRING; 31033.ENSTRUP00000020559; -.
DR PRIDE; Q90YI8; -.
DR eggNOG; KOG4029; Eukaryota.
DR InParanoid; Q90YI8; -.
DR Proteomes; UP000005226; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; ISS:UniProtKB.
DR GO; GO:0048844; P:artery morphogenesis; ISS:UniProtKB.
DR GO; GO:0060216; P:definitive hemopoiesis; ISS:UniProtKB.
DR GO; GO:0060214; P:endocardium formation; ISS:UniProtKB.
DR GO; GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0060217; P:hemangioblast cell differentiation; ISS:UniProtKB.
DR GO; GO:0060218; P:hematopoietic stem cell differentiation; ISS:UniProtKB.
DR GO; GO:0030099; P:myeloid cell differentiation; ISS:UniProtKB.
DR GO; GO:0060215; P:primitive hemopoiesis; ISS:UniProtKB.
DR GO; GO:0001570; P:vasculogenesis; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040238; TAL-like.
DR PANTHER; PTHR13864; PTHR13864; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..371
FT /note="T-cell acute lymphocytic leukemia protein 1"
FT /id="PRO_0000320004"
FT DOMAIN 204..256
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..62
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 263..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 353..371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 371 AA; 40895 MW; B62C6F333AB924AF CRC64;
MMEKRQPELC PGSPDAESGP GKREDAAIIS RQNGCKEDEE SKREEGDKEG GGRFKGDEET
DDVPLQNSSN GTSISIIING VTKETASHNA LDLKREVPVI ELSRRDAIKA VEQRTESHLV
PITELRRPPQ LPLPPQQRDD ARMVQLSPNA FPVPARAMLY NLAQPLAAIN SLGGESEQYS
MYPSNRVKRR PAPYEVELDE AKIVRRIFTN SRERWRQQNV NGAFAELRKL IPTHPPDKKL
SKNEILRLAM KYISFLSNLL EDQDGGRNVS STTDGETGLM VGAHEVGPQG GPHQDRVVGL
ARDDIMETMS PGSSCGSLPD GDADGSPESF MEDQDSPPAP RTLTASRGPP LHLTTRDLRR
NGRPLDGSSR R