TAL1_XENLA
ID TAL1_XENLA Reviewed; 394 AA.
AC O73823; Q6INZ1;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=T-cell acute lymphocytic leukemia protein 1;
DE Short=TAL-1;
DE AltName: Full=Stem cell leukemia protein SCL;
DE Short=xSCL;
GN Name=tal1 {ECO:0000250|UniProtKB:P17542};
GN Synonyms=scl {ECO:0000303|PubMed:11493549, ECO:0000303|PubMed:14559237,
GN ECO:0000303|PubMed:9636076};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC14869.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL
RP STAGE, AND INDUCTION.
RC TISSUE=Tadpole erythrocyte {ECO:0000269|PubMed:9636076};
RX PubMed=9636076; DOI=10.1242/dev.125.14.2611;
RA Mead P.E., Kelley C.M., Hahn P.S., Piedad O., Zon L.I.;
RT "SCL specifies hematopoietic mesoderm in Xenopus embryos.";
RL Development 125:2611-2620(1998).
RN [2] {ECO:0000312|EMBL:AAH72130.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Spleen {ECO:0000312|EMBL:AAH72130.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=11493549; DOI=10.1242/dev.128.12.2301;
RA Mead P.E., Deconinck A.E., Huber T.L., Orkin S.H., Zon L.I.;
RT "Primitive erythropoiesis in the Xenopus embryo: the synergistic role of
RT LMO-2, SCL and GATA-binding proteins.";
RL Development 128:2301-2308(2001).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=14559237; DOI=10.1016/j.bbrc.2003.09.135;
RA Sanada T., Park M.J., Araki A., Gotoh M., Izutsu Y., Maeno M.;
RT "A BMP-4-dependent transcriptional control element in the 5' flanking
RT region of Xenopus SCL gene.";
RL Biochem. Biophys. Res. Commun. 310:1160-1167(2003).
RN [5] {ECO:0000305}
RP INDUCTION.
RX PubMed=17942750; DOI=10.1182/blood-2007-03-081323;
RA Walmsley M., Cleaver D., Patient R.K.;
RT "Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1
RT expression during embryonic blood development.";
RL Blood 111:1157-1166(2008).
CC -!- FUNCTION: Transcription factor that acts synergistically with lmo2 and
CC gata1 to specify embryonic dorsal mesoderm to a hematopoietic fate.
CC {ECO:0000269|PubMed:11493549, ECO:0000269|PubMed:9636076}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P22091,
CC ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: First expressed in patches on the ventral side of
CC the embryo in a region that will give rise to hematopoietic tissue. By
CC late neurula stages, expressed throughout the ventral blood island
CC region. By tailbud stages, expression extends to probable vascular
CC progenitor cells, but is excluded from the presumptive liver anlage.
CC Also expressed in the central nervous system at the tailbud stage.
CC {ECO:0000269|PubMed:14559237, ECO:0000269|PubMed:9636076}.
CC -!- DEVELOPMENTAL STAGE: First expressed at stage 12/13 (gastrula) of
CC embryogenesis, with expression increasing through the tadpole stages.
CC {ECO:0000269|PubMed:9636076}.
CC -!- INDUCTION: By bmp-signaling in the ventral mesoderm. Inhibition by fgf
CC regulates the timing of hematopoiesis. {ECO:0000269|PubMed:14559237,
CC ECO:0000269|PubMed:17942750, ECO:0000269|PubMed:9636076}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH72130.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF060151; AAC14869.1; -; mRNA.
DR EMBL; BC072130; AAH72130.1; ALT_INIT; mRNA.
DR RefSeq; NP_001081746.1; NM_001088277.1.
DR AlphaFoldDB; O73823; -.
DR SMR; O73823; -.
DR DNASU; 398028; -.
DR GeneID; 398028; -.
DR KEGG; xla:398028; -.
DR CTD; 398028; -.
DR Xenbase; XB-GENE-865312; tal1.S.
DR OrthoDB; 1449816at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 398028; Expressed in lung and 13 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0030218; P:erythrocyte differentiation; IGI:UniProtKB.
DR GO; GO:0030097; P:hemopoiesis; IMP:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040238; TAL-like.
DR PANTHER; PTHR13864; PTHR13864; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation.
FT CHAIN 1..394
FT /note="T-cell acute lymphocytic leukemia protein 1"
FT /id="PRO_0000318117"
FT REPEAT 83..89
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 94..100
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 105..111
FT /note="3"
FT /evidence="ECO:0000255"
FT REPEAT 116..122
FT /note="4"
FT /evidence="ECO:0000255"
FT REPEAT 127..133
FT /note="5"
FT /evidence="ECO:0000255"
FT REPEAT 149..155
FT /note="6"
FT /evidence="ECO:0000255"
FT REPEAT 167..173
FT /note="7"
FT /evidence="ECO:0000255"
FT DOMAIN 262..314
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..173
FT /note="7 X 7 AA approximate repeats of [TS]-E-L-C-R-[AP]-P"
FT /evidence="ECO:0000255"
FT REGION 347..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..362
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..378
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 249
FT /note="I -> Y (in Ref. 2; AAH72130)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 394 AA; 43043 MW; 67EB4449B4804E5A CRC64;
MSLKMMERLS TDMDGTRDVA SPPARQDAAE PERTVELSGV KEGAAPNSPP RAVPVIELLR
RGEGLGNIKA REQELRLQNI RTTELCRATL TPATELCRAP LTPTTELCRA PLTPTTELCR
APLTPTTELC RPPLTPAAEF CRASLTPASE LCRAPSSVTG PSLTATTELC RPPIPLPTPS
TGPPAEQAVE ARMVQLSPTA SLPLQAAGRT MLYGLNQPLA SDNSGYFGDP DTFPMYTSNS
RAKRRPGPIE VEISEGPQPK VVRRIFTNSR ERWRQQNVNG AFAELRKLIP THPPDKKLSK
NEILRLAMKY INFLAKLLDD QEEEGNQRNK GNKDNGMVQQ ELLQDMLSPN SSCGSSLDGA
PSPDSYSEEH DALDSKHSRN LHQAMLPIDG SGQR
