TAL2_HUMAN
ID TAL2_HUMAN Reviewed; 108 AA.
AC Q16559; A0AVI7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=T-cell acute lymphocytic leukemia protein 2;
DE Short=TAL-2;
DE AltName: Full=Class A basic helix-loop-helix protein 19;
DE Short=bHLHa19;
GN Name=TAL2; Synonyms=BHLHA19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHROMOSOMAL TRANSLOCATION.
RX PubMed=1763056; DOI=10.1073/pnas.88.24.11416;
RA Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III,
RA Le Beau M.M., Baer R.J.;
RT "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32)
RT translocation in human T-cell leukemia.";
RL Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=8152805;
RA Xia Y., Hwang L.Y., Cobb M.H., Baer R.;
RT "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins
RT with DNA-binding activity.";
RL Oncogene 9:1437-1446(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q16559; P15884: TCF4; NbExp=3; IntAct=EBI-10237959, EBI-533224;
CC -!- DISEASE: Note=A chromosomal aberration involving TAL2 may be a cause of
CC some T-cell acute lymphoblastic leukemia (T-ALL). Translocation
CC t(7;9)(q34;q32) with TCRB. {ECO:0000269|PubMed:1763056}.
CC -!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and
CC Haematology;
CC URL="http://atlasgeneticsoncology.org/Genes/TAL2ID28ch9q31.html";
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DR EMBL; M81078; AAA60613.1; -; Genomic_DNA.
DR EMBL; S69377; AAC60629.1; -; Genomic_DNA.
DR EMBL; AL158070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069422; AAH69422.1; -; mRNA.
DR EMBL; BC126373; AAI26374.1; -; mRNA.
DR EMBL; BC126375; AAI26376.1; -; mRNA.
DR CCDS; CCDS6767.1; -.
DR PIR; A41629; A41629.
DR RefSeq; NP_005412.1; NM_005421.2.
DR AlphaFoldDB; Q16559; -.
DR SMR; Q16559; -.
DR BioGRID; 112750; 10.
DR IntAct; Q16559; 7.
DR STRING; 9606.ENSP00000334547; -.
DR iPTMnet; Q16559; -.
DR PhosphoSitePlus; Q16559; -.
DR BioMuta; TAL2; -.
DR DMDM; 7531207; -.
DR MassIVE; Q16559; -.
DR PaxDb; Q16559; -.
DR PeptideAtlas; Q16559; -.
DR PRIDE; Q16559; -.
DR Antibodypedia; 29308; 75 antibodies from 23 providers.
DR DNASU; 6887; -.
DR Ensembl; ENST00000334077.6; ENSP00000334547.3; ENSG00000186051.7.
DR GeneID; 6887; -.
DR KEGG; hsa:6887; -.
DR MANE-Select; ENST00000334077.6; ENSP00000334547.3; NM_005421.3; NP_005412.1.
DR UCSC; uc004bct.4; human.
DR CTD; 6887; -.
DR DisGeNET; 6887; -.
DR GeneCards; TAL2; -.
DR HGNC; HGNC:11557; TAL2.
DR HPA; ENSG00000186051; Tissue enriched (skeletal).
DR MIM; 186855; gene.
DR neXtProt; NX_Q16559; -.
DR OpenTargets; ENSG00000186051; -.
DR PharmGKB; PA36327; -.
DR VEuPathDB; HostDB:ENSG00000186051; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00940000160867; -.
DR HOGENOM; CLU_158724_0_0_1; -.
DR InParanoid; Q16559; -.
DR OMA; EDCGVPS; -.
DR OrthoDB; 1453623at2759; -.
DR PhylomeDB; Q16559; -.
DR TreeFam; TF315153; -.
DR PathwayCommons; Q16559; -.
DR SignaLink; Q16559; -.
DR SIGNOR; Q16559; -.
DR BioGRID-ORCS; 6887; 9 hits in 1057 CRISPR screens.
DR ChiTaRS; TAL2; human.
DR GeneWiki; TAL2; -.
DR GenomeRNAi; 6887; -.
DR Pharos; Q16559; Tbio.
DR PRO; PR:Q16559; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q16559; protein.
DR Bgee; ENSG00000186051; Expressed in skeletal muscle tissue of rectus abdominis and 114 other tissues.
DR Genevisible; Q16559; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0003677; F:DNA binding; TAS:ProtInc.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030901; P:midbrain development; IEA:Ensembl.
DR GO; GO:0035264; P:multicellular organism growth; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0021794; P:thalamus development; IEA:Ensembl.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040238; TAL-like.
DR PANTHER; PTHR13864; PTHR13864; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Chromosomal rearrangement; DNA-binding; Proto-oncogene; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..108
FT /note="T-cell acute lymphocytic leukemia protein 2"
FT /id="PRO_0000127456"
FT DOMAIN 2..54
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 89..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 108 AA; 12291 MW; DE9D67D940EF4749 CRC64;
MTRKIFTNTR ERWRQQNVNS AFAKLRKLIP THPPDKKLSK NETLRLAMRY INFLVKVLGE
QSLQQTGVAA QGNILGLFPQ GPHLPGLEDR TLLENYQVPS PGPSHHIP
