ID   TAL2_MOUSE              Reviewed;         108 AA.
AC   Q62282;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=T-cell acute lymphocytic leukemia protein 2 homolog;
DE            Short=TAL-2;
GN   Name=Tal2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1763056; DOI=10.1073/pnas.88.24.11416;
RA   Xia Y., Brown L., Yang C.Y.-C., Tsan J.T., Siciliano M.J., Espinosa R. III,
RA   Le Beau M.M., Baer R.J.;
RT   "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32)
RT   translocation in human T-cell leukemia.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:11416-11420(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
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DR   EMBL; M81077; AAA40162.1; -; Genomic_DNA.
DR   EMBL; AK018448; BAB31216.1; -; mRNA.
DR   CCDS; CCDS18192.1; -.
DR   RefSeq; NP_033343.1; NM_009317.3.
DR   AlphaFoldDB; Q62282; -.
DR   SMR; Q62282; -.
DR   BioGRID; 203963; 3.
DR   IntAct; Q62282; 3.
DR   STRING; 10090.ENSMUSP00000030124; -.
DR   iPTMnet; Q62282; -.
DR   PhosphoSitePlus; Q62282; -.
DR   PaxDb; Q62282; -.
DR   PRIDE; Q62282; -.
DR   Antibodypedia; 29308; 75 antibodies from 23 providers.
DR   DNASU; 21350; -.
DR   Ensembl; ENSMUST00000030124; ENSMUSP00000030124; ENSMUSG00000028417.
DR   GeneID; 21350; -.
DR   KEGG; mmu:21350; -.
DR   UCSC; uc008sxg.1; mouse.
DR   CTD; 6887; -.
DR   MGI; MGI:99540; Tal2.
DR   VEuPathDB; HostDB:ENSMUSG00000028417; -.
DR   eggNOG; KOG4029; Eukaryota.
DR   GeneTree; ENSGT00940000160867; -.
DR   HOGENOM; CLU_158724_0_0_1; -.
DR   InParanoid; Q62282; -.
DR   OMA; EDCGVPS; -.
DR   OrthoDB; 1453623at2759; -.
DR   PhylomeDB; Q62282; -.
DR   TreeFam; TF315153; -.
DR   BioGRID-ORCS; 21350; 2 hits in 74 CRISPR screens.
DR   ChiTaRS; Tal2; mouse.
DR   PRO; PR:Q62282; -.
DR   Proteomes; UP000000589; Chromosome 4.
DR   RNAct; Q62282; protein.
DR   Bgee; ENSMUSG00000028417; Expressed in midbrain lateral wall and 26 other tissues.
DR   ExpressionAtlas; Q62282; baseline and differential.
DR   Genevisible; Q62282; MM.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030901; P:midbrain development; IMP:MGI.
DR   GO; GO:0035264; P:multicellular organism growth; IMP:MGI.
DR   GO; GO:0009791; P:post-embryonic development; IMP:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021794; P:thalamus development; IMP:MGI.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR040238; TAL-like.
DR   PANTHER; PTHR13864; PTHR13864; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..108
FT                   /note="T-cell acute lymphocytic leukemia protein 2 homolog"
FT                   /id="PRO_0000127457"
FT   DOMAIN          2..54
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          76..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   108 AA;  12315 MW;  11B8A7711520AF13 CRC64;
     MTRKIFTNTR ERWRQQSVNN AFAKLRKLIP THPPDKKLSK NETLRLAMRY INFLVKVLGE
     QSLHQTGVAA QGNILGLFPP KTRLPDEDDR TLLNDYRVPS PGPSHGAP