位置:首页 > 蛋白库 > TAL3A_DROME
TAL3A_DROME
ID   TAL3A_DROME             Reviewed;          11 AA.
AC   A3RLR0;
DT   17-FEB-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Peptide tarsal-less 3A {ECO:0000312|FlyBase:FBgn0259732};
DE   AltName: Full=Peptide polished rice 3 {ECO:0000312|EMBL:BAF56587.1};
GN   Name=tal-3A {ECO:0000312|FlyBase:FBgn0259732};
GN   Synonyms=pri {ECO:0000312|EMBL:BAF56587.1},
GN   tal {ECO:0000312|FlyBase:FBgn0259732};
GN   ORFNames=CG42386 {ECO:0000312|FlyBase:FBgn0259732};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1] {ECO:0000312|EMBL:BAF56587.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17486114; DOI=10.1038/ncb1595;
RA   Kondo T., Hashimoto Y., Kato K., Inagaki S., Hayashi S., Kageyama Y.;
RT   "Small peptide regulators of actin-based cell morphogenesis encoded by a
RT   polycistronic mRNA.";
RL   Nat. Cell Biol. 9:660-665(2007).
RN   [2] {ECO:0000312|EMBL:ABO09843.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=17439302; DOI=10.1371/journal.pbio.0050106;
RA   Galindo M.I., Pueyo J.I., Fouix S., Bishop S.A., Couso J.P.;
RT   "Peptides encoded by short ORFs control development and define a new
RT   eukaryotic gene family.";
RL   PLoS Biol. 5:E106-E106(2007).
RN   [3] {ECO:0000312|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4] {ECO:0000312|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000312|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5] {ECO:0000312|EMBL:AFA55187.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [6] {ECO:0000305}
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=18801356; DOI=10.1016/j.ydbio.2008.08.025;
RA   Pueyo J.I., Couso J.P.;
RT   "The 11-aminoacid long Tarsal-less peptides trigger a cell signal in
RT   Drosophila leg development.";
RL   Dev. Biol. 324:192-201(2008).
RN   [7] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=20647469; DOI=10.1126/science.1188158;
RA   Kondo T., Plaza S., Zanet J., Benrabah E., Valenti P., Hashimoto Y.,
RA   Kobayashi S., Payre F., Kageyama Y.;
RT   "Small peptides switch the transcriptional activity of Shavenbaby during
RT   Drosophila embryogenesis.";
RL   Science 329:336-339(2010).
RN   [8] {ECO:0000305}
RP   FUNCTION.
RX   PubMed=21527259; DOI=10.1016/j.ydbio.2011.03.033;
RA   Pueyo J.I., Couso J.P.;
RT   "Tarsal-less peptides control Notch signalling through the Shavenbaby
RT   transcription factor.";
RL   Dev. Biol. 355:183-193(2011).
RN   [9] {ECO:0000305}
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=21682860; DOI=10.1186/1423-0127-18-42;
RA   Pi H., Huang Y.C., Chen I.C., Lin C.D., Yeh H.F., Pai L.M.;
RT   "Identification of 11-amino acid peptides that disrupt Notch-mediated
RT   processes in Drosophila.";
RL   J. Biomed. Sci. 18:42-42(2011).
RN   [10] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND INDUCTION BY ECDYSONE.
RX   PubMed=25344753; DOI=10.1038/ncb3052;
RA   Chanut-Delalande H., Hashimoto Y., Pelissier-Monier A., Spokony R., Dib A.,
RA   Kondo T., Bohere J., Niimi K., Latapie Y., Inagaki S., Dubois L.,
RA   Valenti P., Polesello C., Kobayashi S., Moussian B., White K.P., Plaza S.,
RA   Kageyama Y., Payre F.;
RT   "Pri peptides are mediators of ecdysone for the temporal control of
RT   development.";
RL   Nat. Cell Biol. 16:1035-1044(2014).
RN   [11] {ECO:0000305}
RP   FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=26383956; DOI=10.1126/science.aac5677;
RA   Zanet J., Benrabah E., Li T., Pelissier-Monier A., Chanut-Delalande H.,
RA   Ronsin B., Bellen H.J., Payre F., Plaza S.;
RT   "Pri sORF peptides induce selective proteasome-mediated protein
RT   processing.";
RL   Science 349:1356-1358(2015).
CC   -!- FUNCTION: One of four peptides (tal-1A, tal-2A, tal-3A and tal-AA)
CC       produced from a polycistronic gene that function redundantly in several
CC       developmental processes (PubMed:17439302, PubMed:17486114,
CC       PubMed:25344753, PubMed:21527259). Required in early stages of leg
CC       development for the intercalation of the tarsal segments during the
CC       mid-third instar stage and later for tarsal joint formation
CC       (PubMed:17439302, PubMed:18801356, PubMed:21527259). Promotes the post-
CC       translational modification of ovo isoform B (svb) into its active form
CC       which in turn initiates trichome development and promotes tarsal joint
CC       development (PubMed:21527259, PubMed:20647469, PubMed:26383956). This
CC       is likely due to recruitment of the E3 ubiquitin-protein ligase Ubr3 to
CC       svb for ubiquitination of its N-terminus, converting svb into a
CC       transcriptional activator (PubMed:26383956). Also enhances interaction
CC       of Ubr3 with Diap1 (PubMed:26383956). Required for correct wing and leg
CC       formation through its regulation of several genes including those in
CC       the Notch signaling pathway (PubMed:18801356, PubMed:21527259,
CC       PubMed:21682860). Essential for denticle formation and may have a role
CC       in the developmental timing of trichome differentiation
CC       (PubMed:17486114, PubMed:25344753). Essential for the development of
CC       taenidial folds in the trachea (PubMed:17486114).
CC       {ECO:0000269|PubMed:17439302, ECO:0000269|PubMed:17486114,
CC       ECO:0000269|PubMed:18801356, ECO:0000269|PubMed:20647469,
CC       ECO:0000269|PubMed:21527259, ECO:0000269|PubMed:21682860,
CC       ECO:0000269|PubMed:25344753, ECO:0000269|PubMed:26383956}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26383956}. Nucleus
CC       {ECO:0000269|PubMed:26383956}.
CC   -!- DEVELOPMENTAL STAGE: At early stages of embryogenesis, the
CC       polycistronic RNA is expressed in seven segmentally separated
CC       blastoderm stripes and in a cluster of cells in the anterior part of
CC       the embryo (PubMed:17439302). By stage 13 to the end of embryo
CC       development, it is expressed in the dorsal trunks, posterior spiracles,
CC       pharynx, hindgut and the area which forms the denticle belts
CC       (PubMed:17439302). In the leg disk, it is expressed in a ring pattern
CC       presumed to be developing tarsal region around 80 to 96 h after egg
CC       laying (AEL) and then in the tarsal furrow at the mid-third instar
CC       larval stage (PubMed:17439302, PubMed:18801356). Not detected in the
CC       tarsal primordium after 100h AEL but is still expressed in a dorsal
CC       chordotonal organ of the leg disk (PubMed:17439302). In pupae,
CC       expressed broadly throughout the leg disk 0-3 h after puparium
CC       formation (APF) but is not detected in this region 6h APF
CC       (PubMed:25344753). High expression 4-8 h APF in the presumptive joints
CC       between tarsal segments (PubMed:21682860). In the noctum expressed from
CC       40 to 44 h APF (PubMed:25344753). In wing disks of third stage larvae,
CC       expressed in two anterior stripes and later in the precursors for
CC       chemosensory organs (PubMed:21682860). From late third stage instar
CC       larvae to early pupal stages, it is also expressed in the wing provein
CC       cells that develop into longitudinal veins L2-L5 (PubMed:21682860). In
CC       eye disks, expressed in preclusters for presumptive R8 photoreceptors
CC       and in a stripe of cells in the posterior region of the disk
CC       (PubMed:21682860). {ECO:0000269|PubMed:17439302,
CC       ECO:0000269|PubMed:18801356, ECO:0000269|PubMed:21682860,
CC       ECO:0000269|PubMed:25344753}.
CC   -!- INDUCTION: Polycistronic RNA up-regulated by ecdysone.
CC       {ECO:0000269|PubMed:25344753}.
CC   -!- DISRUPTION PHENOTYPE: Simultaneous knockout of tal-1A, tal-2A, tal-3A
CC       and tal-AA is embryonic lethal (PubMed:17439302, PubMed:17486114). In
CC       embryos chitin secretion and formation of the cuticular exoskeleton
CC       appears to be normal (PubMed:17439302, PubMed:17486114). However
CC       embryos display a loss of denticle belts and dorsal hairs
CC       (PubMed:17439302, PubMed:17486114). Segment-specific epidermal sensory
CC       organs are present and segments form normally (PubMed:17439302). The
CC       cephalopharyngeal skeleton is lost, and the head skeleton and posterior
CC       spiracles are deformed (PubMed:17439302). In the developing leg, tarsal
CC       constriction occurs but the tarsal fold does not form
CC       (PubMed:17439302). The tracheal system is abnormal displaying a loss of
CC       network integrity, an irregular tube diameter and the absence of
CC       taenidial folds (PubMed:17439302, PubMed:17486114). Cell packing is not
CC       affected, but there is no accumulation of F-actin at the sites of
CC       denticle differentiation or formation of F-actin bundles during
CC       taenidial development and tracheal tube dilation (stages 14 and 16)
CC       (PubMed:17486114). Other F-actin based developmental processes such as
CC       filopodia formation of tracheal tip cells, dorsal closure, mitosis or
CC       tight packing of denticle cells are unaffected (PubMed:17486114).
CC       Denticle and tracheal defects can be rescued by ectopic expression of
CC       any one of the four tal peptides (tal-1A, tal-2A, tal-3A and tal-AA)
CC       (PubMed:17486114). {ECO:0000269|PubMed:17439302,
CC       ECO:0000269|PubMed:17486114}.
CC   -!- MISCELLANEOUS: This protein is produced by a polycistronic gene which
CC       also produces tal-1A, tal-2A and tal-AA from non-overlapping reading
CC       frames (PubMed:17486114, PubMed:17439302). tal-1A and tal-2A produce
CC       the same protein from different reading frames (PubMed:17486114,
CC       PubMed:17439302). {ECO:0000269|PubMed:17439302,
CC       ECO:0000269|PubMed:17486114}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB300657; BAF56587.1; -; mRNA.
DR   EMBL; EF427619; ABO09843.1; -; mRNA.
DR   EMBL; AE014297; ACL83510.1; -; Genomic_DNA.
DR   EMBL; AY070879; AFA55187.1; -; mRNA.
DR   RefSeq; NP_001138052.1; NM_001144580.2.
DR   EnsemblMetazoa; FBtr0299999; FBpp0289276; FBgn0259732.
DR   GeneID; 7354378; -.
DR   KEGG; dme:Dmel_CG42386; -.
DR   CTD; 7354378; -.
DR   FlyBase; FBgn0259732; tal-3A.
DR   VEuPathDB; VectorBase:FBgn0259732; -.
DR   BioGRID-ORCS; 7354378; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; tal-3A; fly.
DR   GenomeRNAi; 7354378; -.
DR   PRO; PR:A3RLR0; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0259732; Expressed in saliva-secreting gland and 30 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007015; P:actin filament organization; IGI:FlyBase.
DR   GO; GO:0002009; P:morphogenesis of an epithelium; IGI:FlyBase.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Nucleus; Reference proteome.
FT   CHAIN           1..11
FT                   /note="Peptide tarsal-less 3A"
FT                   /id="PRO_0000435527"
SQ   SEQUENCE   11 AA;  1236 MW;  946F2858B76AA72A CRC64;
     MSHDLDPTGT Y
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024