TALA_DICDI
ID TALA_DICDI Reviewed; 1279 AA.
AC P0CE94; P54633; Q54FX1;
DT 23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-MAR-2010, sequence version 1.
DT 25-MAY-2022, entry version 63.
DE RecName: Full=Talin-A;
DE AltName: Full=Filopodin;
GN Name=talA; ORFNames=DDB_G0290481;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Actin-binding protein that may be involved in the control of
CC cell motility and chemotaxis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex
CC {ECO:0000250}.
CC -!- CAUTION: This is a truncated TALA gene product. Strain AX4 has a stop
CC codon in position 1280 which disrupts the gene and produces a truncated
CC protein. On the other hand, strain AX2 produces a full length protein
CC (AC P0CE95). {ECO:0000305}.
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DR EMBL; AAFI02000164; EAL62101.2; -; Genomic_DNA.
DR RefSeq; XP_635646.2; XM_630554.3.
DR AlphaFoldDB; P0CE94; -.
DR SMR; P0CE94; -.
DR PaxDb; P0CE94; -.
DR GeneID; 8627718; -.
DR KEGG; ddi:DDB_G0290481; -.
DR dictyBase; DDB_G0290481; talA.
DR InParanoid; P0CE94; -.
DR PhylomeDB; P0CE94; -.
DR PRO; PR:P0CE94; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR GO; GO:0031254; C:cell trailing edge; IDA:dictyBase.
DR GO; GO:0032154; C:cleavage furrow; IDA:dictyBase.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0032433; C:filopodium tip; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031143; C:pseudopodium; IDA:dictyBase.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:dictyBase.
DR GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; IDA:dictyBase.
DR GO; GO:0000916; P:actomyosin contractile ring contraction; IMP:dictyBase.
DR GO; GO:0000902; P:cell morphogenesis; IMP:dictyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IMP:dictyBase.
DR GO; GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.
DR GO; GO:0036090; P:cleavage furrow ingression; IMP:dictyBase.
DR GO; GO:0000281; P:mitotic cytokinesis; IMP:dictyBase.
DR GO; GO:0006909; P:phagocytosis; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IGI:dictyBase.
DR GO; GO:0034461; P:uropod retraction; IMP:dictyBase.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR SMART; SM00295; B41; 1.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 3: Inferred from homology;
KW Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..1279
FT /note="Talin-A"
FT /id="PRO_0000219427"
FT DOMAIN 84..365
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
SQ SEQUENCE 1279 AA; 139484 MW; 3F96A0B193702CF7 CRC64;
MSISLKINIV GANTVKTLRF APDMCIQECC THIFEKTNEG GPDHGLYQAH IEGKQSARWL
AMEKTLQFYD INSDQQLDYK KKHRPQKFKL LDGTIKTQLV DESQNVSEIV NSICKKMGIK
NPEEYSLMNS AGAWLNNTQI LSEQGISEND ITVLMKKFFF NDANIDRNDP VQLHLLFVQC
RDGIIEGKYP TQREESLALS ALQCQVQLGD YNPTKHVPGF LTLKDYLPLQ WLKSKGVEKD
IFKEHKKLVS MTEVNAKYRY VQLCRSLKTY GMTSFDVKIR EYGKKKMVDH ILGITREQML
LMLTETKEVI MTHPLKHIKR WAATDKSFTL DFGDHETEYL ILQTPNPEQI SQLIGGYIEI
IMKARKDSSK VIEKEDTAMG VEEVMAVKKG SVANSSSYMG YGAGGGGANQ LQPSQQIPIT
DLKSALRATD LLIGELGGFR SSTGATPQNF TRSFTTLTPQ QFKHQLISHT NAMAIAAQGL
FQDMTTPPPT GGIAAFQQAI TKRAQIIMAE LNTVGTAAKN AGYFPDMASF SDEIIGVATK
LSESMARLLA IGSTIQGTDC DEKSQKAAQT EIFNVQSLVT LMMAACDNEY VTDSSSKLLI
ECAKNVSAAI ADMLVVGNSK VEFIDDELLL GQIQNTLKST SLTSDELLST TENLASTSCH
PESRKQITNI TQSALNQSNA LLTAFKSGEI PEQDYNLLNA RVSDIIESVN LINYAMDCSE
REYKISITSN GVEVGEGEIL AGTNLTEEFA TVANDLTNAI MTMRSNLKNP DTVMESYKMV
AGHANRLITC TKAVASRADT QSQQRLFNST NAVFESVANL SNHCRSYIKN PEQEAHTFQI
VETAGHLQFL TQNMSTDAGK IACITSLRDY SKEMIAQVSS LISTSRTSSQ YLPDANGITL
LKGAKDVSDA LSKLMVGIKK VVLDPKSEAT QMELLTLAQK QSLPPMNLVS TCKRFAPKIS
DPNQKQRLIF SSDAAAQSVQ KLMKAGEAYK RICGHIEIEE ALEVFDSTIA DLETTEIAIA
GGFLDAVSGT TREGAAELLM VAIKDLNKVN NELVTDIRVN PARLGDLVKS ATESASSVAI
SAKTLICATT GKQVQKKLMG ITKQLMIDME QLIRASRSVA SNPNDAASEL LLDAASNDVS
ISTAALVGST ANVDCKELDE ASADISNLLS LKMGSLESIL SQPTEEFAFY VEEIASSTKA
LNAASQQVVA MARNKNLKGL GASAKITASA LSTLVSHAQN AIVLTENEAT KNAILASTVA
LGGQIIGLLD FSKARIANY
