TALB_DICDI
ID TALB_DICDI Reviewed; 2614 AA.
AC Q54K81; O97054;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=Talin-B;
GN Name=talB; ORFNames=DDB_G0287505;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=AX2;
RX PubMed=10209124; DOI=10.1016/s0960-9822(99)80169-9;
RA Tsujioka M., Machesky L.M., Cole S.L., Yahata K., Inouye K.;
RT "A unique talin homologue with a villin headpiece-like domain is required
RT for multicellular morphogenesis in Dictyostelium.";
RL Curr. Biol. 9:389-392(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Actin-binding protein required for multicellular
CC morphogenesis. Substrate of pkgB and/or pkbA.
CC {ECO:0000269|PubMed:10209124}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm,
CC cell cortex {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed during growth and throughout
CC development. The expression level is developmentally regulated. It
CC reaches a maximum at the monut stage. {ECO:0000269|PubMed:10209124}.
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DR EMBL; AB023655; BAA75511.1; -; mRNA.
DR EMBL; AAFI02000102; EAL63652.1; -; Genomic_DNA.
DR RefSeq; XP_637174.1; XM_632082.1.
DR AlphaFoldDB; Q54K81; -.
DR SMR; Q54K81; -.
DR BioGRID; 1251178; 1.
DR STRING; 44689.DDB0191526; -.
DR PaxDb; Q54K81; -.
DR PRIDE; Q54K81; -.
DR EnsemblProtists; EAL63652; EAL63652; DDB_G0287505.
DR GeneID; 8626175; -.
DR KEGG; ddi:DDB_G0287505; -.
DR dictyBase; DDB_G0287505; talB.
DR eggNOG; KOG0445; Eukaryota.
DR eggNOG; KOG4261; Eukaryota.
DR HOGENOM; CLU_000364_1_1_1; -.
DR InParanoid; Q54K81; -.
DR OMA; VDMTQHY; -.
DR PhylomeDB; Q54K81; -.
DR Reactome; R-DDI-114608; Platelet degranulation.
DR PRO; PR:Q54K81; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005938; C:cell cortex; IDA:dictyBase.
DR GO; GO:0031252; C:cell leading edge; IDA:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IDA:dictyBase.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0140220; C:pathogen-containing vacuole; HDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0031143; C:pseudopodium; IDA:dictyBase.
DR GO; GO:0051015; F:actin filament binding; IDA:dictyBase.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IDA:dictyBase.
DR GO; GO:0051017; P:actin filament bundle assembly; IDA:dictyBase.
DR GO; GO:0048102; P:autophagic cell death; IMP:dictyBase.
DR GO; GO:0048870; P:cell motility; IMP:dictyBase.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0031589; P:cell-substrate adhesion; IGI:dictyBase.
DR GO; GO:0040011; P:locomotion; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR CDD; cd14473; FERM_B-lobe; 1.
DR Gene3D; 1.10.950.10; -; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR036723; Alpha-catenin/vinculin-like_sf.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR032425; FERM_f0.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR035964; I/LWEQ_dom_sf.
DR InterPro; IPR002558; ILWEQ_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR003128; Villin_headpiece.
DR InterPro; IPR036886; Villin_headpiece_dom_sf.
DR Pfam; PF16511; FERM_f0; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF01608; I_LWEQ; 1.
DR Pfam; PF02209; VHP; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00307; ILWEQ; 1.
DR SMART; SM00153; VHP; 1.
DR SUPFAM; SSF109885; SSF109885; 4.
DR SUPFAM; SSF47031; SSF47031; 1.
DR SUPFAM; SSF47050; SSF47050; 1.
DR SUPFAM; SSF47220; SSF47220; 5.
DR SUPFAM; SSF54236; SSF54236; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51089; HP; 1.
DR PROSITE; PS50945; I_LWEQ; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Coiled coil; Cytoplasm; Cytoskeleton; Reference proteome.
FT CHAIN 1..2614
FT /note="Talin-B"
FT /id="PRO_0000312330"
FT DOMAIN 85..369
FT /note="FERM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT DOMAIN 2219..2460
FT /note="I/LWEQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00292"
FT DOMAIN 2553..2614
FT /note="HP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00595"
FT REGION 393..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2454..2557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1938..1965
FT /evidence="ECO:0000255"
FT COILED 2033..2057
FT /evidence="ECO:0000255"
FT COMPBIAS 393..410
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2456..2489
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2512..2550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 1069
FT /note="Q -> P (in Ref. 1; BAA75511)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2614 AA; 277729 MW; 1E33F35180EF3620 CRC64;
MSLTLKIQIV RDKQVKAMKF SPTQTVAEVC AQVREKINET SGDDHGLFQP GIDAKRPSRW
LKMDKTLQFY DLKINDELDY KKKHRPLKVR LMDETVKTML VDDSLTAGEI LEIIGKRIGI
KNYEEFSLQT EGAAAGEWIN HAQPLHEQGV PDDAVVLLKK KFFVDDFNVN RDDPIQLHLV
YVQSRDAIIS GSHPCSYEEA VQFGALQCQI QLGNHNPNLH KPGYLKIKEY FPPSFHKKKD
AEKDIYKEFR KLTGMSESNS KFRYVQLCRS LKTYGITFFL TKERVKGQKK PVPKLLGITR
DSILRLDAET KEVEHEYPLN HLRRWAASPQ SFTLDFGDYE DDYVSVITTE GEAISQLLSG
YIEILMKKRK DTGTVIDENE TDIANVESVG RIRGQTSQAT TSSSLSGYDG NGGREGQYSA
PGQAIGYRGG LGGPLSIKVT NIDSASAAVA NLLNEMELDP NAVIGQKSSL TPQQWRQQLA
IHAKAVAAAA GKLLGNLNNP NGMDKNQMDS NARDVALTID QLVHAARAAS IASGEDPDGE
MPLFDGAKAV AESISKLLKA TKDLSSNPND ENARNLIAQA ADQLKLMTSY LDGACNGVIT
DSGTLRLLME AGKAIAIATQ DLVNQANVAI QDINDPIRKN QLNMAIDETM KAGIHASAVS
QALAATILDP NCRQQFNTAA KTAQDTNNYL LSAAKAAQMD PALLEKLRAS AKSIAEAYAS
LIQSADLAQP KSGDDVEFTS ASKTILSAAA QLLGSQGKSD NIMQQAKVIE EAMGHLIAGA
RRAALKTDDP GVRDRLIQCS KAVAEAVRNL MEIAQDSADN PEDKVLFAKL QESSKRVATA
VKQLVGDAGK ESAFQLLRTN AKLACAATTG LMNTSRQSML QGHLSDQESN KLLLACVQAG
PAITNLLNSI TSSQKAPNDL PAQNQLIEVA RVSAPIAYQV VAVAKGAIPH FTDQHSKQEV
SNSSNTASDA IRALLDAIGD LTSAVGQQEF DDALDTVQAL EADMESSTML VQAGTTHQIP
GQTRENALEL LNVAARALGS SAKQVLLQYK TSPEKLGETS KDLATSVSQV TNAAKSVCFT
TQNRSVQKAV LGAAKQITTE STNLVSCARA VSSNPGDPSL ESALQSSVKA IAEALANLLT
TSKGGDPGGK DLDDAIEAIK NDTKRINNPP VNLGGEGGVN SEKAISSSKA LVGAVSQVAA
NARSNPSALG ASARTTSTTF TLLVDTINLC TGTIVNKQLA IEIVKGGQLL GIETIKLLQA
SRFAASRPGE GEGELNQTQQ SVSNTVKQLI YNIQSSVPGQ AEIADALEIV KQAIIALNSS
ESSGSRPNAL ESLTQAAKNL ADYTAQVVQS KGNSEKMGTQ CKSASESLKD VVEYTKASLS
TAEGHPDSIK TLASKVDDSS NALFNSCKKT GQLSDQDKKN AALDAKNLAL SVPNLMGAAK
KISASLVQSN PEKSKDILLV AQNITIATSK LVNIAKSVAS GQSQADVSQL AATKKEVSEL
ISKLLNATNG HDQDATTISI DLDSLSKSEQ ALLDASRSTA NYMSQFMAIG KTISTGTKDP
NVHQQFSGAA QNVSSGVQQL LSAINGMKPE QKDLDESIEI IQNAVVDLDS ATLNAAIGLL
ENTAPVGKTA QVCQEELVDI SRELATSMKT FLAAPKQDPT NLGQSAKDTA NILPKIVNIS
KQLASLTTNP DIKQTQLLLS KKLADNMLEL MISAKSGDVS DSKQAFNASQ SIADILTSVK
GGVMQSRDCD ESIQIIGKSK ENLQKPANDT HGKTYQQYRD EMTEIAKQLA LGVSQLANSA
KSKPEEIGSS SLKIASIIPR LAETARSTAA ATNDVAAKKK LIDSTTGIID ATSNIISDAK
LASADHKNTQ LQQKISNNFK DITTQIANLI AALRAGATAD RDIENACNEV NHVTTDLDAA
SLFAAAGQID IDTDGHTTQN IQEQVGKLAQ DLKDSKNQLA EASGKTIEDV GTSAKATASI
NQKLAHATKV CAALTSDSTT QQNLLSAART VSSNLQQTIS ASKNAQKNPN AGNKAILDKS
SQELEESIDS LANLVQSSTT TKGISELEGV SSEIRKQLAA YDSATANVNA NATAEDVVNS
AKNLAESIAY LVSSCNNSPE DIAEASKGTT LAIKSLLANA KGASVLTDDA VIQQNVTESA
KAAAQTVLKL IQAAKQQRND PSNPAHQNKL SEISSEVVES ISTCVNAAED LPEGKRAKLL
FAAGESLEET AEKELKAAAA IIEEATAALL NAKKKREQNR IASGIDEAGI DESILEAARA
ITSATGVLVQ CATNVQHELV LAGKVGNKGN MYRRDPTWAR GLISAAQAVA GSVQGLVHSA
NSSSQGKVDE EQLVASAKGV AAATARLVTA SRAKADLNSA SNSQLAQAAK QVSNATAALV
EAAKQVNEEP EVEFDTTNLS NAQIISKEMD QQIQILKLKK ELEQAEKKLF SIRKKEYSDQ
TGNPSPAKDS DNKPTTSISV GITPTKRTTQ ASPPSPPLTP TQQAAGTPTL PPRPLMKKPA
PSQAPSSPVA PVSAPVSKPS PKPAPKPAAP TAAAPNKTYT LEELKKKPAN IDHSNLEIYL
SDEEFKAVFN CERSELAAMP TWKRNNIKTK LGLF
