BPOC_MYCTU
ID BPOC_MYCTU Reviewed; 262 AA.
AC P9WNH1; L0T713; O06420; Q7D9N2;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 37.
DE RecName: Full=Putative non-heme bromoperoxidase BpoC;
GN Name=bpoC; OrderedLocusNames=Rv0554;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN [3] {ECO:0007744|PDB:3HZO}
RP X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 2-262 IN COMPLEX WITH SUBSTRATE
RP ANALOGS, AND SUBUNIT.
RA Johnston J.M., Baker E.N.;
RT "The structure of Rv0554 from Mycobacterium tuberculosis.";
RL Submitted (JUN-2009) to the PDB data bank.
RN [4] {ECO:0007744|PDB:3E3A, ECO:0007744|PDB:3HSS, ECO:0007744|PDB:3HYS}
RP X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 2-262 IN COMPLEX WITH SUBSTRATE
RP ANALOGS, SUBUNIT, AND ACTIVE SITE.
RX PubMed=20693690; DOI=10.1107/s0907444910025771;
RA Johnston J.M., Jiang M., Guo Z., Baker E.N.;
RT "Structural and functional analysis of Rv0554 from Mycobacterium
RT tuberculosis: testing a putative role in menaquinone biosynthesis.";
RL Acta Crystallogr. D 66:909-917(2010).
RN [5] {ECO:0007744|PDB:7LD8}
RP X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF 2-262.
RA DeBouver N.D., Dranow D.M., Lorimer D.D., Horanyi P.S., Edwards T.E.;
RT "Crystal structure of putative non-heme bromoperoxidase BpoC from
RT Mycobacterium tuberculosis H37Rv.";
RL Submitted (JAN-2021) to the PDB data bank.
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:20693690, ECO:0000269|Ref.3}.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP43292.1; -; Genomic_DNA.
DR PIR; E70548; E70548.
DR RefSeq; NP_215068.1; NC_000962.3.
DR RefSeq; WP_003402925.1; NZ_NVQJ01000036.1.
DR PDB; 3E3A; X-ray; 2.35 A; A/B=2-262.
DR PDB; 3HSS; X-ray; 1.90 A; A/B=2-262.
DR PDB; 3HYS; X-ray; 2.30 A; A/B=2-262.
DR PDB; 3HZO; X-ray; 2.60 A; A/B=2-262.
DR PDB; 7LD8; X-ray; 1.50 A; A=2-262.
DR PDBsum; 3E3A; -.
DR PDBsum; 3HSS; -.
DR PDBsum; 3HYS; -.
DR PDBsum; 3HZO; -.
DR PDBsum; 7LD8; -.
DR AlphaFoldDB; P9WNH1; -.
DR SMR; P9WNH1; -.
DR STRING; 83332.Rv0554; -.
DR ESTHER; myctu-bpoC; 6_AlphaBeta_hydrolase.
DR PaxDb; P9WNH1; -.
DR DNASU; 887535; -.
DR GeneID; 45424518; -.
DR GeneID; 887535; -.
DR KEGG; mtu:Rv0554; -.
DR TubercuList; Rv0554; -.
DR eggNOG; COG2267; Bacteria.
DR OMA; DWIDMFT; -.
DR PhylomeDB; P9WNH1; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0019806; F:bromide peroxidase activity; IEA:UniProtKB-EC.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProt.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR Pfam; PF12697; Abhydrolase_6; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Oxidoreductase; Peroxidase; Reference proteome.
FT CHAIN 1..262
FT /note="Putative non-heme bromoperoxidase BpoC"
FT /id="PRO_0000414587"
FT ACT_SITE 87
FT /evidence="ECO:0000305|PubMed:20693690"
FT ACT_SITE 211
FT /evidence="ECO:0000305|PubMed:20693690"
FT ACT_SITE 239
FT /evidence="ECO:0000305|PubMed:20693690"
FT BINDING 21
FT /ligand="substrate"
FT /evidence="ECO:0000305|PubMed:20693690, ECO:0000305|Ref.3"
FT BINDING 87..88
FT /ligand="substrate"
FT /evidence="ECO:0000305|PubMed:20693690, ECO:0000305|Ref.3"
FT BINDING 120
FT /ligand="substrate"
FT /evidence="ECO:0000305|PubMed:20693690, ECO:0000305|Ref.3"
FT BINDING 239
FT /ligand="substrate"
FT /evidence="ECO:0000305|PubMed:20693690, ECO:0000305|Ref.3"
FT STRAND 6..18
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 25..28
FT /evidence="ECO:0007829|PDB:7LD8"
FT TURN 29..32
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 33..38
FT /evidence="ECO:0007829|PDB:7LD8"
FT STRAND 42..46
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 52..54
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 62..75
FT /evidence="ECO:0007829|PDB:7LD8"
FT STRAND 80..86
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 88..99
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 101..103
FT /evidence="ECO:0007829|PDB:7LD8"
FT STRAND 104..111
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 118..133
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 139..150
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 153..156
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 159..171
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 178..184
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 193..196
FT /evidence="ECO:0007829|PDB:7LD8"
FT STRAND 203..208
FT /evidence="ECO:0007829|PDB:7LD8"
FT STRAND 212..214
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 216..225
FT /evidence="ECO:0007829|PDB:7LD8"
FT STRAND 229..234
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 241..244
FT /evidence="ECO:0007829|PDB:7LD8"
FT HELIX 246..259
FT /evidence="ECO:0007829|PDB:7LD8"
SQ SEQUENCE 262 AA; 28381 MW; 26C4F811521EE0DD CRC64;
MINLAYDDNG TGDPVVFIAG RGGAGRTWHP HQVPAFLAAG YRCITFDNRG IGATENAEGF
TTQTMVADTA ALIETLDIAP ARVVGVSMGA FIAQELMVVA PELVSSAVLM ATRGRLDRAR
QFFNKAEAEL YDSGVQLPPT YDARARLLEN FSRKTLNDDV AVGDWIAMFS MWPIKSTPGL
RCQLDCAPQT NRLPAYRNIA APVLVIGFAD DVVTPPYLGR EVADALPNGR YLQIPDAGHL
GFFERPEAVN TAMLKFFASV KA
