ID   BPP12_BOTAT             Reviewed;          12 AA.
AC   P86721;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   29-SEP-2021, entry version 17.
DE   RecName: Full=Bradykinin-potentiating peptide 12a;
DE            Short=BPP-12a;
DE   AltName: Full=Bradykinin-potentiating peptide BAX12a {ECO:0000303|Ref.1};
OS   Bothrops atrox (Barba amarilla) (Fer-de-lance).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=8725;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom {ECO:0000269|Ref.1};
RA   Coutinho-Neto A., Cardozo-Filho J.L., Caldeira C.A.S., Silva L.P.,
RA   Bloch C. Jr., Calderon L.A., Stabeli R.G.;
RT   "Identification of peptides from Amazonian Bothrops atrox venom by MALDI
RT   TOF/TOF.";
RL   Submitted (JUL-2010) to UniProtKB.
CC   -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC       converting enzyme (ACE) and enhances the action of bradykinin by
CC       inhibiting the peptidases that inactivate it. It acts as an indirect
CC       hypotensive agent (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000269|Ref.1}.
CC   -!- MASS SPECTROMETRY: Mass=1384.6; Mass_error=0.05; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..12
FT                   /note="Bradykinin-potentiating peptide 12a"
FT                   /id="PRO_0000399055"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|Ref.1"
SQ   SEQUENCE   12 AA;  1402 MW;  6824EF5638C76AB4 CRC64;
     QQWPRDPAPI PP