ID   BPP1_GLOHA              Reviewed;          11 AA.
AC   P04562;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   29-SEP-2021, entry version 62.
DE   RecName: Full=Bradykinin-potentiating peptide 1;
DE            Short=BPP-1;
DE   AltName: Full=Angiotensin-converting enzyme inhibitor 1;
OS   Gloydius halys (Chinese water mocassin) (Agkistrodon halys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
OX   NCBI_TaxID=8714;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, PYROGLUTAMATE FORMATION AT GLN-1, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=3008123;
RA   Chi C.-W., Wang S.-Z., Xu L.-G., Wang M.-Y., Lo S.-S., Huang W.-D.;
RT   "Structure-function studies on the bradykinin potentiating peptide from
RT   Chinese snake venom (Agkistrodon halys pallas).";
RL   Peptides 6 Suppl. 3:339-342(1985).
CC   -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC       converting enzyme (ACE) and enhances the action of bradykinin by
CC       inhibiting the peptidases that inactivate it. It acts as an indirect
CC       hypotensive agent. {ECO:0000269|PubMed:3008123}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:3008123}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   PIR; JC0002; XAVIBH.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..11
FT                   /note="Bradykinin-potentiating peptide 1"
FT                   /id="PRO_0000043506"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:3008123"
SQ   SEQUENCE   11 AA;  1112 MW;  30BABF1277686777 CRC64;
     QGRPPGPPIP P