BPP2_GLOHA
ID BPP2_GLOHA Reviewed; 11 AA.
AC P85038;
DT 14-DEC-2011, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 29-SEP-2021, entry version 16.
DE RecName: Full=Bradykinin-potentiating peptide 2 {ECO:0000303|Ref.1};
DE Short=AHBPP-2 {ECO:0000303|Ref.1};
DE AltName: Full=Angiotensin-converting enzyme inhibitor 2 {ECO:0000303|Ref.1};
OS Gloydius halys (Chinese water mocassin) (Agkistrodon halys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Gloydius.
OX NCBI_TaxID=8714;
RN [1] {ECO:0000305}
RP PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC TISSUE=Venom {ECO:0000269|Ref.1};
RA Guo C.T.;
RT "Molecular analysis of the bioactive components in snake venoms.";
RL Submitted (NOV-2006) to UniProtKB.
CC -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC converting enzyme (ACE) and enhances the action of bradykinin by
CC inhibiting the peptidases that inactivate it. It acts as an indirect
CC hypotensive agent. {ECO:0000269|Ref.1}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305|Ref.1}.
CC -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW Secreted; Toxin.
FT PEPTIDE 1..11
FT /note="Bradykinin-potentiating peptide 2"
FT /evidence="ECO:0000250|UniProtKB:P04562"
FT /id="PRO_0000414617"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250|UniProtKB:P04562"
SQ SEQUENCE 11 AA; 1251 MW; 30BABF04F7741777 CRC64;
QGRPPRPHIP P