ID   BPP36_CROAT             Reviewed;          10 AA.
AC   P0C7S6;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   29-SEP-2021, entry version 21.
DE   RecName: Full=Bradykinin-potentiating peptide POL-236;
DE            Short=BPP POL-236;
OS   Crotalus atrox (Western diamondback rattlesnake).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus.
OX   NCBI_TaxID=8730;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom;
RX   PubMed=3831966; DOI=10.1016/0196-9781(85)90395-x;
RA   Politi V., De Luca G., Di Stazio G., Schinina E., Bossa F.;
RT   "A new peptide from Crotalus atrox snake venom.";
RL   Peptides 6:343-346(1985).
RN   [2]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom;
RX   PubMed=19371136; DOI=10.1021/pr900249q;
RA   Calvete J.J., Fasoli E., Sanz L., Boschetti E., Righetti P.G.;
RT   "Exploring the venom proteome of the western diamondback rattlesnake,
RT   Crotalus atrox, via snake venomics and combinatorial peptide ligand library
RT   approaches.";
RL   J. Proteome Res. 8:3055-3067(2009).
CC   -!- FUNCTION: This peptide acts as a hypotensive peptides, but its action
CC       is not related to angiotensin-converting enzyme (ACE) inhibition.
CC       {ECO:0000269|PubMed:3831966}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- MASS SPECTROMETRY: Mass=1213.8; Method=Unknown; Note=Average mass.;
CC       Evidence={ECO:0000269|PubMed:19371136};
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..10
FT                   /note="Bradykinin-potentiating peptide POL-236"
FT                   /id="PRO_0000343190"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:19371136,
FT                   ECO:0000269|PubMed:3831966"
SQ   SEQUENCE   10 AA;  1231 MW;  324F3546C7741773 CRC64;
     QLWPRPQIPP