BPPAD_BOTFO
ID BPPAD_BOTFO Reviewed; 10 AA.
AC P0DJK5;
DT 03-APR-2013, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 1.
DT 29-SEP-2021, entry version 14.
DE RecName: Full=Bradykinin-potentiating peptide 10d;
DE Short=BPP-10d;
OS Bothrops fonsecai (Fonseca's lancehead) (Rhinocerophis fonsecai).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX NCBI_TaxID=157549;
RN [1]
RP PROTEIN SEQUENCE, SYNTHESIS, FUNCTION, PYROGLUTAMATE FORMATION AT GLN-1,
RP AND MASS SPECTROMETRY.
RC TISSUE=Venom;
RX PubMed=22869554; DOI=10.1074/mcp.m112.019331;
RA Tashima A.K., Zelanis A., Kitano E.S., Ianzer D., Melo R.L., Rioli V.,
RA Sant'anna S.S., Schenberg A.C., Camargo A.C., Serrano S.M.T.;
RT "Peptidomics of three Bothrops snake venoms: insights into the molecular
RT diversification of proteomes and peptidomes.";
RL Mol. Cell. Proteomics 11:1245-1262(2012).
CC -!- FUNCTION: This peptide evokes slight hypotension (-2 mmHg), when
CC injected alone into rats. It has a no bradykinin-potentiating effect,
CC when 60 nmol of BPP-10d are coinjected with 0.5 ug of bradykinin into
CC rats. It inhibits angiotensin converting enzyme (ACE) activity with a
CC K(i)app of 9.12 uM. {ECO:0000269|PubMed:22869554}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- MASS SPECTROMETRY: Mass=1182.7; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:22869554};
CC -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC {ECO:0000305}.
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DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW Secreted; Toxin.
FT PEPTIDE 1..10
FT /note="Bradykinin-potentiating peptide 10d"
FT /id="PRO_0000421907"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:22869554"
SQ SEQUENCE 10 AA; 1200 MW; 30C533877761F773 CRC64;
QNWPHPPMPP