ID   18KD_MYCLE              Reviewed;         148 AA.
AC   P12809;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=18 kDa antigen;
DE   AltName: Full=HSP 16.7;
GN   Name=hsp18; OrderedLocusNames=ML1795;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3056923; DOI=10.1128/jb.170.12.5919-5921.1988;
RA   Nerland A.H., Mustafa A.S., Sweetser D., Godal T., Young R.A.;
RT   "A protein antigen of Mycobacterium leprae is related to a family of small
RT   heat shock proteins.";
RL   J. Bacteriol. 170:5919-5921(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2447183;
RA   Booth R.J., Harris D.P., Love J.M., Watson J.D.;
RT   "Antigenic proteins of Mycobacterium leprae. Complete sequence of the gene
RT   for the 18-kDa protein.";
RL   J. Immunol. 140:597-601(1988).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- FUNCTION: Not known. This protein is one of the major immune reactive
CC       proteins in mycobacteria.
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; M22587; AAA25343.1; -; Genomic_DNA.
DR   EMBL; M19058; AAA88229.1; -; Genomic_DNA.
DR   EMBL; AL583923; CAC30748.1; -; Genomic_DNA.
DR   PIR; A27586; A27586.
DR   RefSeq; NP_302218.1; NC_002677.1.
DR   RefSeq; WP_010908539.1; NC_002677.1.
DR   AlphaFoldDB; P12809; -.
DR   SMR; P12809; -.
DR   MINT; P12809; -.
DR   STRING; 272631.ML1795; -.
DR   EnsemblBacteria; CAC30748; CAC30748; CAC30748.
DR   KEGG; mle:ML1795; -.
DR   PATRIC; fig|272631.5.peg.3418; -.
DR   Leproma; ML1795; -.
DR   eggNOG; COG0071; Bacteria.
DR   HOGENOM; CLU_046737_9_0_11; -.
DR   OMA; TNRPAVM; -.
DR   Proteomes; UP000000806; Chromosome.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   Pfam; PF00011; HSP20; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..148
FT                   /note="18 kDa antigen"
FT                   /id="PRO_0000126016"
FT   DOMAIN          21..131
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   CONFLICT        13..20
FT                   /note="RFAEQVLG -> LRRASVS (in Ref. 1; AAA25343)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        100
FT                   /note="E -> Q (in Ref. 1; AAA25343)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   148 AA;  16707 MW;  82B11CC40845C391 CRC64;
     MLMRTDPFRE LDRFAEQVLG TSARPAVMPM DAWREGEEFV VEFDLPGIKA DSLDIDIERN
     VVTVRAERPG VDPDREMLAA ERPRGVFNRQ LVLGENLDTE RILASYQEGV LKLSIPVAER
     AKPRKISVDR GNNGHQTINK TAHEIIDA