ID   AC100_MYCTU             Reviewed;          78 AA.
AC   P9WM65; L0T2L2; P64687; Q10895;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Acyl carrier protein Rv0100 {ECO:0000305};
GN   OrderedLocusNames=Rv0100; ORFNames=MTCY251.19;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
RN   [3]
RP   FUNCTION.
RX   PubMed=22451903; DOI=10.1073/pnas.1118680109;
RA   Chhabra A., Haque A.S., Pal R.K., Goyal A., Rai R., Joshi S., Panjikar S.,
RA   Pasha S., Sankaranarayanan R., Gokhale R.S.;
RT   "Nonprocessive [2 + 2]e- off-loading reductase domains from mycobacterial
RT   nonribosomal peptide synthetases.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:5681-5686(2012).
RN   [4]
RP   FUNCTION.
RX   PubMed=23625916; DOI=10.1074/jbc.m113.466912;
RA   Liu Z., Ioerger T.R., Wang F., Sacchettini J.C.;
RT   "Structures of Mycobacterium tuberculosis FadD10 protein reveal a new type
RT   of adenylate-forming enzyme.";
RL   J. Biol. Chem. 288:18473-18483(2013).
RN   [5]
RP   CRYSTALLIZATION.
RX   PubMed=31584013; DOI=10.1107/s2053230x19012652;
RA   Bondoc J.M.G., Gutka H.J., Almutairi M.M., Patwell R., Rutter M.W.,
RA   Wolf N.M., Samudrala R., Mehboob S., Movahedzadeh F.;
RT   "Rv0100, a proposed acyl carrier protein in Mycobacterium tuberculosis:
RT   expression, purification and crystallization.";
RL   Acta Crystallogr. F Struct. Biol. Commun. 75:646-651(2019).
RN   [6]
RP   ERRATUM OF PUBMED:31584013.
RX   PubMed=32254053; DOI=10.1107/s2053230x2000271x;
RA   Bondoc J.M.G., Gutka H.J., Almutairi M.M., Patwell R., Rutter M.W.,
RA   Wolf N.M., Samudrala R., Mehboob S., Dementiev A., Abad-Zapatero C.,
RA   Movahedzadeh F.;
RT   "Rv0100, a proposed acyl carrier protein in Mycobacterium tuberculosis:
RT   expression, purification and crystallization. Corrigendum.";
RL   Acta Crystallogr. F Struct. Biol. Commun. 76:192-193(2020).
CC   -!- FUNCTION: Acyl carrier protein that accepts acyl-adenylates (acyl-AMP)
CC       from FadD10. {ECO:0000269|PubMed:22451903,
CC       ECO:0000269|PubMed:23625916}.
CC   -!- PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the acyl carrier protein (ACP) family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP42825.1; -; Genomic_DNA.
DR   PIR; D70751; D70751.
DR   RefSeq; NP_214614.1; NC_000962.3.
DR   RefSeq; WP_003400793.1; NZ_NVQJ01000053.1.
DR   AlphaFoldDB; P9WM65; -.
DR   SMR; P9WM65; -.
DR   STRING; 83332.Rv0100; -.
DR   PaxDb; P9WM65; -.
DR   GeneID; 886931; -.
DR   KEGG; mtu:Rv0100; -.
DR   PATRIC; fig|83332.111.peg.114; -.
DR   TubercuList; Rv0100; -.
DR   eggNOG; ENOG5031TJP; Bacteria.
DR   OMA; VLYIDEQ; -.
DR   UniPathway; UPA00199; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1200.10; -; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   Pfam; PF00550; PP-binding; 1.
DR   SUPFAM; SSF47336; SSF47336; 1.
DR   PROSITE; PS50075; CARRIER; 1.
PE   1: Evidence at protein level;
KW   Fatty acid metabolism; Lipid metabolism; Phosphopantetheine;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..78
FT                   /note="Acyl carrier protein Rv0100"
FT                   /id="PRO_0000103671"
FT   DOMAIN          1..78
FT                   /note="Carrier"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
FT   MOD_RES         35
FT                   /note="O-(pantetheine 4'-phosphoryl)serine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00258"
SQ   SEQUENCE   78 AA;  8693 MW;  D9D4A843852ED446 CRC64;
     MRDRILAAVC DVLYIDEADL IDGDETDLRD LGLDSVRFVL LMKQLGVNRQ SELPSRLAAN
     PSIAGWLREL EAVCTEFG