ID   BPPCB_BOTJA             Reviewed;          12 AA.
AC   P0DM54;
DT   24-JUL-2013, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2013, sequence version 1.
DT   29-SEP-2021, entry version 14.
DE   RecName: Full=Bradykinin-potentiating peptide 12b;
DE            Short=BPP-12b;
OS   Bothrops jararaca (Jararaca) (Bothrops jajaraca).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=8724;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, PYROGLUTAMATE
RP   FORMATION AT GLN-1, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Venom;
RX   PubMed=20146532; DOI=10.1021/pr901027r;
RA   Zelanis A., Tashima A.K., Rocha M.M., Furtado M.F., Camargo A.C., Ho P.L.,
RA   Serrano S.M.;
RT   "Analysis of the ontogenetic variation in the venom proteome/peptidome of
RT   Bothrops jararaca reveals different strategies to deal with prey.";
RL   J. Proteome Res. 9:2278-2291(2010).
CC   -!- FUNCTION: Bradykinin-potentiating peptides both inhibits the activity
CC       of the angiotensin-converting enzyme (ACE) and enhances the action of
CC       bradykinin by inhibiting the peptidases that inactivate it. It acts as
CC       an indirect hypotensive agent (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- DEVELOPMENTAL STAGE: This protein seems to be found in adult B.jararaca
CC       venom but not in newborn snake venom. {ECO:0000269|PubMed:20146532}.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..12
FT                   /note="Bradykinin-potentiating peptide 12b"
FT                   /id="PRO_0000423035"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:20146532"
SQ   SEQUENCE   12 AA;  1297 MW;  3230A57E92741777 CRC64;
     QLGPPPRPQI PP