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BPPCC_BOTJA
ID   BPPCC_BOTJA             Reviewed;          12 AA.
AC   P85162; P85166;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   23-FEB-2022, entry version 32.
DE   RecName: Full=Bradykinin-potentiating peptide 12c;
DE            Short=BPP-12c;
DE   Contains:
DE     RecName: Full=Bradykinin-potentiating peptide 9a;
DE              Short=BPP-9a;
DE              Short=BPP-a;
DE     AltName: Full=Bradykinin-potentiating peptide V-6-I;
DE              Short=BPPV-6-I;
DE     AltName: Full=Teprotide;
DE   Contains:
DE     RecName: Full=Bradykinin-potentiating peptide 9a-F;
DE              Short=BPP-9a-F;
DE     AltName: Full=Bradykinin-potentiating peptide 5b;
DE              Short=BPP-5b;
OS   Bothrops jararaca (Jararaca) (Bothrops jajaraca).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=8724;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE (BPP-9A AND BPP-12C), FUNCTION, SUBCELLULAR LOCATION,
RP   TISSUE SPECIFICITY, MASS SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-1
RP   AND GLN-4.
RC   TISSUE=Venom {ECO:0000269|PubMed:15245866};
RX   PubMed=15245866; DOI=10.1016/j.peptides.2004.04.006;
RA   Ianzer D., Konno K., Marques-Porto R., Portaro F.C.V., Stoecklin R.,
RA   de Camargo A.C.M., Pimenta D.C.;
RT   "Identification of five new bradykinin potentiating peptides (BPPs) from
RT   Bothrops jararaca crude venom by using electrospray ionization tandem mass
RT   spectrometry after a two-step liquid chromatography.";
RL   Peptides 25:1085-1092(2004).
RN   [2]
RP   PROTEIN SEQUENCE (BPP-9A AND BPP-12C), PYROGLUTAMATE FORMATION AT GLN-1 AND
RP   GLN-4, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=22869554; DOI=10.1074/mcp.m112.019331;
RA   Tashima A.K., Zelanis A., Kitano E.S., Ianzer D., Melo R.L., Rioli V.,
RA   Sant'anna S.S., Schenberg A.C., Camargo A.C., Serrano S.M.T.;
RT   "Peptidomics of three Bothrops snake venoms: insights into the molecular
RT   diversification of proteomes and peptidomes.";
RL   Mol. Cell. Proteomics 11:1245-1262(2012).
RN   [3]
RP   PROTEIN SEQUENCE, PYROGLUTAMATE FORMATION AT GLN-1, DEVELOPMENTAL STAGE
RP   (BPP-12C), AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom;
RX   PubMed=20146532; DOI=10.1021/pr901027r;
RA   Zelanis A., Tashima A.K., Rocha M.M., Furtado M.F., Camargo A.C., Ho P.L.,
RA   Serrano S.M.;
RT   "Analysis of the ontogenetic variation in the venom proteome/peptidome of
RT   Bothrops jararaca reveals different strategies to deal with prey.";
RL   J. Proteome Res. 9:2278-2291(2010).
RN   [4]
RP   PROTEIN SEQUENCE OF 4-9, AND FUNCTION.
RC   TISSUE=Venom;
RX   PubMed=4334402; DOI=10.1021/bi00798a004;
RA   Ondetti M.A., Williams N.J., Sabo E.F., Pluscec J., Weaver E.R., Kocy O.;
RT   "Angiotensin-converting enzyme inhibitors from the venom of Bothrops
RT   jararaca. Isolation, elucidation of structure, and synthesis.";
RL   Biochemistry 10:4033-4039(1971).
RN   [5]
RP   PROTEIN SEQUENCE OF 4-9, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-4.
RC   TISSUE=Venom;
RX   PubMed=15912471; DOI=10.1002/rcm.1973;
RA   Wermelinger L.S., Dutra D.L., Oliveira-Carvalho A.L., Soares M.R.,
RA   Bloch C. Jr., Zingali R.B.;
RT   "Fast analysis of low molecular mass compounds present in snake venom:
RT   identification of ten new pyroglutamate-containing peptides.";
RL   Rapid Commun. Mass Spectrom. 19:1703-1708(2005).
RN   [6]
RP   PROTEIN SEQUENCE OF 4-8 (BPP-9A-F), FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, MASS SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-4.
RC   TISSUE=Venom;
RX   PubMed=17315274; DOI=10.1002/rcm.2931;
RA   Pimenta D.C., Prezoto B.C., Konno K., de Melo R.L., Furtado M.F.,
RA   de Camargo A.C.M., Serrano S.M.T.;
RT   "Mass spectrometric analysis of the individual variability of Bothrops
RT   jararaca venom peptide fraction. Evidence for sex-based variation among the
RT   bradykinin-potentiating peptides.";
RL   Rapid Commun. Mass Spectrom. 21:1034-1042(2007).
RN   [7]
RP   SYNTHESIS OF 4-12 (BPP-9A), AND FUNCTION.
RX   PubMed=11994001; DOI=10.1021/bi012121x;
RA   Cotton J., Hayashi M.A., Cuniasse P., Vazeux G., Ianzer D.,
RA   De Camargo A.C., Dive V.;
RT   "Selective inhibition of the C-domain of angiotensin I converting enzyme by
RT   bradykinin potentiating peptides.";
RL   Biochemistry 41:6065-6071(2002).
RN   [8]
RP   PHARMACEUTICAL.
RX   PubMed=200262; DOI=10.1021/bi00644a014;
RA   Cushman D.W., Cheung H.S., Sabo E.F., Ondetti M.A.;
RT   "Design of potent competitive inhibitors of angiotensin-converting enzyme.
RT   Carboxyalkanoyl and mercaptoalkanoyl amino acids.";
RL   Biochemistry 16:5484-5491(1977).
CC   -!- FUNCTION: [Bradykinin-potentiating peptide 9a]: Inhibits the activity
CC       of the angiotensin-converting enzyme (ACE) by a preferential
CC       interaction with its C-domain. May also potentiate the hypotensive
CC       effects of bradykinin.
CC   -!- FUNCTION: [Bradykinin-potentiating peptide 9a-F]: Has much lower
CC       activity than BPP-9a.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15245866,
CC       ECO:0000269|PubMed:15912471, ECO:0000269|PubMed:17315274}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:15245866, ECO:0000269|PubMed:15912471,
CC       ECO:0000269|PubMed:17315274}.
CC   -!- DEVELOPMENTAL STAGE: This protein seems to be found in newborn
CC       B.jararaca venom but not in adult snake venom.
CC       {ECO:0000269|PubMed:20146532}.
CC   -!- MASS SPECTROMETRY: [Bradykinin-potentiating peptide 9a]: Mass=1101.3;
CC       Method=Electrospray; Note=BPP-9a.;
CC       Evidence={ECO:0000269|PubMed:15245866};
CC   -!- MASS SPECTROMETRY: [Bradykinin-potentiating peptide 9a]: Mass=1101.46;
CC       Method=MALDI; Note=BPP-9a.; Evidence={ECO:0000269|PubMed:15912471};
CC   -!- MASS SPECTROMETRY: [Bradykinin-potentiating peptide 9a-F]: Mass=665.8;
CC       Method=Electrospray; Note=BPP-9a-F.;
CC       Evidence={ECO:0000269|PubMed:15245866};
CC   -!- MASS SPECTROMETRY: [Bradykinin-potentiating peptide 9a-F]: Mass=665.33;
CC       Method=MALDI; Note=BPP-9a-F.; Evidence={ECO:0000269|PubMed:17315274};
CC   -!- MASS SPECTROMETRY: [Bradykinin-potentiating peptide 12c]: Mass=1485.8;
CC       Method=Electrospray; Note=BPP-12c.;
CC       Evidence={ECO:0000269|PubMed:15245866, ECO:0000269|PubMed:22869554};
CC   -!- PHARMACEUTICAL: The nonapeptide BPP-9a was synthesized under the name
CC       SQ-20881. It greatly clarified the importance of ACE in hypertension.
CC       However, it's lack of oral activity limits it's therapeutic utility.
CC   -!- MISCELLANEOUS: Bradykinin-potentiating peptide 9a-F is present only in
CC       female snakes. {ECO:0000305|PubMed:17315274}.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Pharmaceutical; Protease inhibitor;
KW   Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   PEPTIDE         1..12
FT                   /note="Bradykinin-potentiating peptide 12c"
FT                   /evidence="ECO:0000269|PubMed:15245866"
FT                   /id="PRO_0000292923"
FT   PEPTIDE         4..12
FT                   /note="Bradykinin-potentiating peptide 9a"
FT                   /id="PRO_0000292915"
FT   PEPTIDE         4..8
FT                   /note="Bradykinin-potentiating peptide 9a-F"
FT                   /id="PRO_0000292916"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:15245866,
FT                   ECO:0000269|PubMed:20146532, ECO:0000269|PubMed:22869554"
FT   MOD_RES         4
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:15245866,
FT                   ECO:0000269|PubMed:15912471, ECO:0000269|PubMed:17315274,
FT                   ECO:0000269|PubMed:22869554"
SQ   SEQUENCE   12 AA;  1504 MW;  287226C992741773 CRC64;
     QWAQWPRPQI PP
 
 
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