TAM41_BOVIN
ID TAM41_BOVIN Reviewed; 335 AA.
AC Q32L81;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 25-MAY-2022, entry version 68.
DE RecName: Full=Phosphatidate cytidylyltransferase, mitochondrial;
DE EC=2.7.7.41 {ECO:0000250|UniProtKB:D3ZKT0};
DE AltName: Full=CDP-diacylglycerol synthase;
DE Short=CDP-DAG synthase;
DE AltName: Full=Mitochondrial translocator assembly and maintenance protein 41 homolog;
DE Short=TAM41;
GN Name=TAMM41;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Liver;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-
CC diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of
CC phosphatidylglycerol, cardiolipin and phosphatidylinositol.
CC {ECO:0000250|UniProtKB:D3ZKT0}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230;
CC Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC {ECO:0000250|UniProtKB:D3ZKT0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side
CC {ECO:0000250|UniProtKB:P53230}.
CC -!- SIMILARITY: Belongs to the TAM41 family. {ECO:0000305}.
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DR EMBL; BC109718; AAI09719.1; -; mRNA.
DR RefSeq; NP_001073242.1; NM_001079774.1.
DR AlphaFoldDB; Q32L81; -.
DR SMR; Q32L81; -.
DR STRING; 9913.ENSBTAP00000004316; -.
DR PaxDb; Q32L81; -.
DR GeneID; 514330; -.
DR KEGG; bta:514330; -.
DR CTD; 132001; -.
DR eggNOG; KOG2986; Eukaryota.
DR HOGENOM; CLU_030279_1_2_1; -.
DR InParanoid; Q32L81; -.
DR OrthoDB; 1145430at2759; -.
DR UniPathway; UPA00557; UER00614.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR InterPro; IPR015222; Tam41.
DR PANTHER; PTHR13619; PTHR13619; 1.
DR Pfam; PF09139; Tam41_Mmp37; 1.
DR PIRSF; PIRSF028840; Mmp37; 1.
PE 2: Evidence at transcript level;
KW Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Nucleotidyltransferase;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transferase; Transit peptide.
FT CHAIN 1..335
FT /note="Phosphatidate cytidylyltransferase, mitochondrial"
FT /id="PRO_0000248353"
SQ SEQUENCE 335 AA; 37420 MW; AA84ADCDAC4511B3 CRC64;
MALQALQSSG VAFRKILSHF PEELSLAFAY GSGVYRQAGP SSDQKNAMLD FVFTVDDPWH
SKNLKRNWNH YSFLKVLGPR IITAVQNNYG AGVYYNTLIT CDGRLIKYGV ISTSVLIEDL
LNWNNLYIAG RLQKPVKIVA MNEDVALRSA LDQNLKSAVT AAFLMLPESF SEEDLFTEIA
GLSYSGDFRM VVGEDKAKVL NIVKPNMAHF RELYGSILQE SPQVVYKAQQ GSLEIDKSPE
GQFTQLMTLP KTLQQQINHI MDPPGKNRDV EETLLQVAHD PDCGDVVRLG LAAIVRPSSM
RQSTKGIFTA GLKKSVVYSS LKLHKMWKGW VRKTS