ID   TAM41_CAEBR             Reviewed;         321 AA.
AC   Q61X59; A8WW89;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Phosphatidate cytidylyltransferase, mitochondrial;
DE            EC=2.7.7.41 {ECO:0000250|UniProtKB:P53230};
DE   AltName: Full=CDP-diacylglycerol synthase;
DE            Short=CDP-DAG synthase;
DE   AltName: Full=Mitochondrial translocator assembly and maintenance protein 41 homolog;
DE            Short=TAM41;
GN   ORFNames=CBG04116;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from
CC       phosphatidic acid (PA) in the mitochondrial inner membrane. Required
CC       for the biosynthesis of the dimeric phospholipid cardiolipin, which
CC       stabilizes supercomplexes of the mitochondrial respiratory chain in the
CC       mitochondrial inner membrane. {ECO:0000250|UniProtKB:P53230}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC         diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC       Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC       Note=Magnesium. Also active with cobalt or copper.
CC       {ECO:0000250|UniProtKB:P53230};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC       diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC       {ECO:0000250|UniProtKB:P53230}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P53230}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:P53230}; Matrix side
CC       {ECO:0000250|UniProtKB:P53230}.
CC   -!- SIMILARITY: Belongs to the TAM41 family. {ECO:0000305}.
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DR   EMBL; HE600956; CAP24898.1; -; Genomic_DNA.
DR   RefSeq; XP_002639511.1; XM_002639465.1.
DR   AlphaFoldDB; Q61X59; -.
DR   SMR; Q61X59; -.
DR   STRING; 6238.CBG04116; -.
DR   EnsemblMetazoa; CBG04116.1; CBG04116.1; WBGene00026852.
DR   GeneID; 8581504; -.
DR   KEGG; cbr:CBG_04116; -.
DR   CTD; 8581504; -.
DR   WormBase; CBG04116; CBP01061; WBGene00026852; -.
DR   eggNOG; KOG2986; Eukaryota.
DR   HOGENOM; CLU_030279_1_2_1; -.
DR   InParanoid; Q61X59; -.
DR   OMA; HYSFLKF; -.
DR   OrthoDB; 1145430at2759; -.
DR   UniPathway; UPA00557; UER00614.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR015222; Tam41.
DR   PANTHER; PTHR13619; PTHR13619; 1.
DR   Pfam; PF09139; Tam41_Mmp37; 1.
DR   PIRSF; PIRSF028840; Mmp37; 1.
PE   3: Inferred from homology;
KW   Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nucleotidyltransferase;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase.
FT   CHAIN           1..321
FT                   /note="Phosphatidate cytidylyltransferase, mitochondrial"
FT                   /id="PRO_0000248358"
SQ   SEQUENCE   321 AA;  36705 MW;  EB39B920EC8BFD94 CRC64;
     MDEYRELISV LPLDTVEYAF AYGSGAIQQK DENKAEKMVD FVVVTKDAQE FHKANIAKNP
     QHYSLLRLLG PKMLEKIQCN FAARVYYNTH VNVGKRKIKY GIISYENVKQ DLLDWRWIYI
     SGRLHKPVLD VIKPKDDMCD LVTENRRSAL HSALLLLPES FTLKQLFHQI VGLSYTGDFR
     MIVGEDKNKI MKIVEGNYEE LMRVYEPLMN DDARLSVMSP AKVIQDGSTT AIYHRLNLLP
     SEVLNQIQKN MNKAQKRQRD AEEVIFSLAH RHDVAATVET AIGGIIRPIS FSQTAKNAFS
     AGMTRSVIYS LAKMSKFLKS K