TAM41_CAEEL
ID TAM41_CAEEL Reviewed; 321 AA.
AC Q9N4G7;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2001, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Phosphatidate cytidylyltransferase, mitochondrial;
DE EC=2.7.7.41 {ECO:0000250|UniProtKB:P53230};
DE AltName: Full=CDP-diacylglycerol synthase;
DE Short=CDP-DAG synthase;
DE AltName: Full=Mitochondrial translocator assembly and maintenance protein 41 homolog;
DE Short=TAM41;
GN ORFNames=Y71F9B.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from
CC phosphatidic acid (PA) in the mitochondrial inner membrane. Required
CC for the biosynthesis of the dimeric phospholipid cardiolipin, which
CC stabilizes supercomplexes of the mitochondrial respiratory chain in the
CC mitochondrial inner membrane. {ECO:0000250|UniProtKB:P53230}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC Note=Magnesium. Also active with cobalt or copper.
CC {ECO:0000250|UniProtKB:P53230};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC {ECO:0000250|UniProtKB:P53230}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P53230}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P53230}; Matrix side
CC {ECO:0000250|UniProtKB:P53230}.
CC -!- SIMILARITY: Belongs to the TAM41 family. {ECO:0000305}.
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DR EMBL; FO081276; CCD70409.1; -; Genomic_DNA.
DR RefSeq; NP_491034.1; NM_058633.1.
DR AlphaFoldDB; Q9N4G7; -.
DR SMR; Q9N4G7; -.
DR BioGRID; 37317; 1.
DR STRING; 6239.Y71F9B.2; -.
DR EPD; Q9N4G7; -.
DR PaxDb; Q9N4G7; -.
DR PeptideAtlas; Q9N4G7; -.
DR EnsemblMetazoa; Y71F9B.2a.1; Y71F9B.2a.1; WBGene00022126.
DR GeneID; 171836; -.
DR KEGG; cel:CELE_Y71F9B.2; -.
DR UCSC; Y71F9B.2; c. elegans.
DR CTD; 171836; -.
DR WormBase; Y71F9B.2a; CE28809; WBGene00022126; -.
DR eggNOG; KOG2986; Eukaryota.
DR GeneTree; ENSGT00390000000616; -.
DR HOGENOM; CLU_030279_1_1_1; -.
DR InParanoid; Q9N4G7; -.
DR OMA; HWRHLYL; -.
DR OrthoDB; 1145430at2759; -.
DR PhylomeDB; Q9N4G7; -.
DR UniPathway; UPA00557; UER00614.
DR PRO; PR:Q9N4G7; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00022126; Expressed in germ line (C elegans) and 4 other tissues.
DR ExpressionAtlas; Q9N4G7; baseline and differential.
DR GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR InterPro; IPR015222; Tam41.
DR PANTHER; PTHR13619; PTHR13619; 1.
DR Pfam; PF09139; Tam41_Mmp37; 1.
DR PIRSF; PIRSF028840; Mmp37; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Nucleotidyltransferase;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transferase.
FT CHAIN 1..321
FT /note="Phosphatidate cytidylyltransferase, mitochondrial"
FT /id="PRO_0000248359"
SQ SEQUENCE 321 AA; 36952 MW; AE534A8D375B775D CRC64;
MDEYRELISV LPLETVEYAF AYGSGAIQQQ NEDKSEKMVD FVIVTKNAQE FHRDNILKNP
QHYSLLRLMG PKMIEKIQCN FAARVYYNTH VKVGKRKIKY GVISYENVKQ DLLDWRWIYI
SGRLHKPVLE VIKPRQDMCD LVTENRRSAL HSSLLLLPES FTLKQLFHKI VGLSYTGDFR
MVVGEDKNKI NKIVEGNYEE LLRVYEPLMN DDARLSVMSP AKLIQDGSTT AIYHRLNLLP
SEVLNRIQKN MNRVQKRQRD AEEVIFSLAH RHDVAATVET AIGGIIRPVS LSQTAKNAFS
AGVTRSIIYS MAKMSKFLKS K
