ID   TAM41_DANRE             Reviewed;         338 AA.
AC   Q3B7H2;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Phosphatidate cytidylyltransferase, mitochondrial;
DE            EC=2.7.7.41 {ECO:0000250|UniProtKB:D3ZKT0};
DE   AltName: Full=CDP-diacylglycerol synthase;
DE            Short=CDP-DAG synthase;
DE   AltName: Full=Mitochondrial translocator assembly and maintenance protein 41 homolog;
DE            Short=TAM41;
GN   Name=tamm41; ORFNames=zgc:123195;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-
CC       diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of
CC       phosphatidylglycerol, cardiolipin and phosphatidylinositol.
CC       {ECO:0000250|UniProtKB:D3ZKT0}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC         diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC         Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230;
CC         Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC       diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC       {ECO:0000250|UniProtKB:D3ZKT0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side
CC       {ECO:0000250|UniProtKB:P53230}.
CC   -!- SIMILARITY: Belongs to the TAM41 family. {ECO:0000305}.
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DR   EMBL; BC107608; AAI07609.1; -; mRNA.
DR   RefSeq; NP_001032196.1; NM_001037119.1.
DR   AlphaFoldDB; Q3B7H2; -.
DR   SMR; Q3B7H2; -.
DR   STRING; 7955.ENSDARP00000058668; -.
DR   PaxDb; Q3B7H2; -.
DR   GeneID; 641323; -.
DR   KEGG; dre:641323; -.
DR   CTD; 132001; -.
DR   ZFIN; ZDB-GENE-051030-99; tamm41.
DR   eggNOG; KOG2986; Eukaryota.
DR   InParanoid; Q3B7H2; -.
DR   OrthoDB; 1145430at2759; -.
DR   PhylomeDB; Q3B7H2; -.
DR   BRENDA; 2.7.7.41; 928.
DR   UniPathway; UPA00557; UER00614.
DR   PRO; PR:Q3B7H2; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR015222; Tam41.
DR   PANTHER; PTHR13619; PTHR13619; 1.
DR   Pfam; PF09139; Tam41_Mmp37; 1.
DR   PIRSF; PIRSF028840; Mmp37; 1.
PE   2: Evidence at transcript level;
KW   Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nucleotidyltransferase;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase.
FT   CHAIN           1..338
FT                   /note="Phosphatidate cytidylyltransferase, mitochondrial"
FT                   /id="PRO_0000248356"
SQ   SEQUENCE   338 AA;  38245 MW;  652591A1A8ACC517 CRC64;
     MSLPALQNSA VFYRRIINRF PQDFSLAFAY GSAVFRQTGS SQGHMVKNML DFVFAVDDPV
     TWHTMNLIEN RKHYSFLRFL GPKQISSIQS DYGAGVYFNT LVPAEDRLIK YGVISTDALI
     DDLLHWKTLY VAGRLHKPVR ILLQSENGNL RSALLGNLKS AVIASFLMLP ESFSEEELYL
     QIAGLSYSGD FRMVFGEDKS KVSNIVKDNM QHFRQLYNRI LQECPQVVYK PQQGRLEVDK
     SPEGQFTQLM ALPRTLQQQI TRLVDRPGKN RDVEEILLQV AQDPDCGSVV QQGISSIVKS
     SSITQSAKGI ATAGLVKTVS YSTKKLQKMW RGWRRKPA