TAM41_DICDI
ID TAM41_DICDI Reviewed; 427 AA.
AC Q550P4;
DT 03-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Phosphatidate cytidylyltransferase, mitochondrial;
DE EC=2.7.7.41 {ECO:0000250|UniProtKB:D3ZKT0};
DE AltName: Full=CDP-diacylglycerol synthase;
DE Short=CDP-DAG synthase;
DE AltName: Full=Mitochondrial translocator assembly and maintenance protein 41 homolog;
DE Short=TAM41;
GN ORFNames=DDB_G0277049;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Catalyzes the formation of CDP-diacylglycerol (CDP-DAG) from
CC phosphatidic acid (PA) in the mitochondrial inner membrane. Required
CC for the biosynthesis of the dimeric phospholipid cardiolipin, which
CC stabilizes supercomplexes of the mitochondrial respiratory chain in the
CC mitochondrial inner membrane. {ECO:0000250|UniProtKB:D3ZKT0}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16230;
CC Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000250|UniProtKB:P53230};
CC -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC {ECO:0000250|UniProtKB:D3ZKT0}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side
CC {ECO:0000250|UniProtKB:P53230}.
CC -!- SIMILARITY: Belongs to the TAM41 family. {ECO:0000305}.
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DR EMBL; AAFI02000019; EAL69026.1; -; Genomic_DNA.
DR RefSeq; XP_642888.1; XM_637796.1.
DR AlphaFoldDB; Q550P4; -.
DR SMR; Q550P4; -.
DR STRING; 44689.DDB0238433; -.
DR PaxDb; Q550P4; -.
DR EnsemblProtists; EAL69026; EAL69026; DDB_G0277049.
DR GeneID; 8620754; -.
DR KEGG; ddi:DDB_G0277049; -.
DR dictyBase; DDB_G0277049; -.
DR eggNOG; KOG2986; Eukaryota.
DR HOGENOM; CLU_030279_1_1_1; -.
DR InParanoid; Q550P4; -.
DR OMA; RWHELNI; -.
DR PhylomeDB; Q550P4; -.
DR UniPathway; UPA00557; UER00614.
DR PRO; PR:Q550P4; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005759; C:mitochondrial matrix; ISS:dictyBase.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR GO; GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
DR GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IBA:GO_Central.
DR InterPro; IPR015222; Tam41.
DR PANTHER; PTHR13619; PTHR13619; 1.
DR Pfam; PF09139; Tam41_Mmp37; 1.
DR PIRSF; PIRSF028840; Mmp37; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Nucleotidyltransferase;
KW Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW Transferase.
FT CHAIN 1..427
FT /note="Phosphatidate cytidylyltransferase, mitochondrial"
FT /id="PRO_0000365592"
FT REGION 94..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 427 AA; 48982 MW; 8F7595F75A95DD52 CRC64;
MIRNLTLLSK SSLDPKCLIL KHSNKNLNNY FKQITFRYYS KTNPIIKQQN HNNINNYNNT
TPETQERINE LLKLFPPIKY GFAYGSGVIS QKGYNRNGDG STSTENPSKK EEQSPMIDLI
FAVENSTKWH SLNLVNNQSH YSFLGLMGAH IVAKVQYMNA KIYFNTLLEH NGIKFKYGVI
EYKDLIDDLK NWKTLYLSGR MQKPIFNLPT SSTEGLKEIQ EINSEYNLKN AVITSLLMLP
ETFTEYDLYH TISKLSYSGD IRMKGAENPM KTHNIVINNI DGFRSLYFPI INDHLTQYLN
VILENGDEVN SSLILSQNNN NKNNNKNETT TTAAPKMVTF KSKQDPMNYL NLLMMLPGSI
KSTMLKEVRN NMKLMKSDEK IDPTILHNLI FMIVSKSSFA QTVKGVFTAG ISKSLNYMKL
KLKKNKK
