ID   TAM41_XENLA             Reviewed;         338 AA.
AC   Q6DJM2;
DT   05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Phosphatidate cytidylyltransferase, mitochondrial;
DE            EC=2.7.7.41 {ECO:0000250|UniProtKB:D3ZKT0};
DE   AltName: Full=CDP-diacylglycerol synthase;
DE            Short=CDP-DAG synthase;
DE   AltName: Full=Mitochondrial translocator assembly and maintenance protein 41 homolog;
DE            Short=TAM41;
GN   Name=tamm41;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-
CC       diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of
CC       phosphatidylglycerol, cardiolipin and phosphatidylinositol.
CC       {ECO:0000250|UniProtKB:D3ZKT0}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-
CC         diacyl-sn-glycerol + diphosphate; Xref=Rhea:RHEA:16229,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:33019, ChEBI:CHEBI:37563,
CC         ChEBI:CHEBI:58332, ChEBI:CHEBI:58608; EC=2.7.7.41;
CC         Evidence={ECO:0000250|UniProtKB:D3ZKT0};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000250|UniProtKB:P53230};
CC   -!- PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-
CC       diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
CC       {ECO:0000250|UniProtKB:D3ZKT0}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:D3ZKT0}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:D3ZKT0}; Matrix side
CC       {ECO:0000250|UniProtKB:P53230}.
CC   -!- SIMILARITY: Belongs to the TAM41 family. {ECO:0000305}.
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DR   EMBL; BC075154; AAH75154.1; -; mRNA.
DR   AlphaFoldDB; Q6DJM2; -.
DR   SMR; Q6DJM2; -.
DR   UniPathway; UPA00557; UER00614.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0019898; C:extrinsic component of membrane; ISS:UniProtKB.
DR   GO; GO:0031314; C:extrinsic component of mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0004605; F:phosphatidate cytidylyltransferase activity; ISS:UniProtKB.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0016024; P:CDP-diacylglycerol biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR015222; Tam41.
DR   PANTHER; PTHR13619; PTHR13619; 1.
DR   Pfam; PF09139; Tam41_Mmp37; 1.
DR   PIRSF; PIRSF028840; Mmp37; 1.
PE   2: Evidence at transcript level;
KW   Lipid biosynthesis; Lipid metabolism; Magnesium; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Nucleotidyltransferase;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase.
FT   CHAIN           1..338
FT                   /note="Phosphatidate cytidylyltransferase, mitochondrial"
FT                   /id="PRO_0000248357"
SQ   SEQUENCE   338 AA;  37893 MW;  04D937F732E57B3E CRC64;
     MSLPVLQGTG FQFRRILSFF PQDISLAFTY GSGVFRQAGS SHNDVRNKML DFVFAVDDPV
     TWHTMNIIQN RSHYSFLKFL GPKHITAVQN NYGAGVYYNT LVPCDGRLIK YGVVSTETLL
     QDLLHWRTLY IAGRLHKPVK ILTQRDDGRL KSALTSNLKS ALNAAFLMLP ESFSEEELYL
     QIAGLSYAGD FRMIIGEDKD KVLNIVKPNV PHFQKLYAAI LLDCPLAVYK AQQGRVEVDK
     SPEGQYQQLM ALPKKLQQNI TALVDPPGKN RDVEEILLQV AQDPDCSSVI QQALYGIVRS
     SSLSQSAKGI VTAGVKKSVQ YSSKKLYKML RSLRRGKS