TAMA_HAEIN
ID TAMA_HAEIN Reviewed; 578 AA.
AC P44038;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Translocation and assembly module subunit TamA;
DE AltName: Full=Autotransporter assembly factor TamA;
DE Flags: Precursor;
GN Name=tama; OrderedLocusNames=HI_0698;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=10675023;
RX DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA Fountoulakis M.;
RT "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL Electrophoresis 21:411-429(2000).
CC -!- FUNCTION: Part of the translocation and assembly module (TAM)
CC autotransporter assembly complex, which functions in translocation of
CC autotransporters across the outer membrane. Has anion selective
CC channel-forming ability, but the physiological relevance of this
CC activity is unclear. {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- SUBUNIT: Interacts with TamB. {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- DOMAIN: Contains 3 N-terminal periplasmic polypeptide transport-
CC associated (POTRA) domains and a C-terminal 16-stranded beta-barrel
CC transmembrane region. The beta-barrel is closed on the extracellular
CC face by loop 6 (residues 456-495), while the C-terminal beta-strand
CC forms an inward kink which may act as a gate for substrate access from
CC the periplasm. This kink weakens the beta-strand pair between the first
CC and last strands which may contribute to gating and substrate
CC translocation. {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- SIMILARITY: Belongs to the TamA family. {ECO:0000305}.
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DR EMBL; L42023; AAC22357.1; -; Genomic_DNA.
DR PIR; B64012; B64012.
DR RefSeq; NP_438857.1; NC_000907.1.
DR RefSeq; WP_010869035.1; NC_000907.1.
DR AlphaFoldDB; P44038; -.
DR SMR; P44038; -.
DR STRING; 71421.HI_0698; -.
DR EnsemblBacteria; AAC22357; AAC22357; HI_0698.
DR KEGG; hin:HI_0698; -.
DR PATRIC; fig|71421.8.peg.729; -.
DR eggNOG; COG0729; Bacteria.
DR HOGENOM; CLU_018618_1_0_6; -.
DR OMA; ALRYWNN; -.
DR PhylomeDB; P44038; -.
DR BioCyc; HINF71421:G1GJ1-732-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0045203; C:integral component of cell outer membrane; IBA:GO_Central.
DR GO; GO:0097347; C:TAM protein secretion complex; IBA:GO_Central.
DR GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR035243; TamA_POTRA_Dom_1.
DR PANTHER; PTHR12815; PTHR12815; 1.
DR Pfam; PF01103; Omp85; 1.
DR Pfam; PF17243; POTRA_TamA_1; 1.
PE 1: Evidence at protein level;
KW Cell outer membrane; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane beta strand.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..578
FT /note="Translocation and assembly module subunit TamA"
FT /id="PRO_0000013947"
FT TRANSMEM 265..276
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 279..288
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 297..306
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 309..317
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 327..336
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 347..356
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 361..370
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 387..395
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 406..415
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 428..437
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 444..453
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 500..508
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 514..523
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 536..545
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 549..557
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 569..578
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
SQ SEQUENCE 578 AA; 65812 MW; 34F9AC189C505876 CRC64;
MKKKSLKLTA LFLALSCFPA FAEQTVDIEV QGIRGFRAVR NTDLNVNLIN KEEMDGSERY
QHLVTKAVDR GLRVFGYYES SVRFERKQRQ GKRDLLIAHV TPGEPTKIAG TDVQIEGEAA
QDENFNALRK NLPKDGVLVE HQTYDDYKTA ISRLALNRGY FDGNFKISRL EISPETHQAW
WRMLFDSGVR YHYGNITFSH SQIRDDYLNN ILNIKSGDPY LMNNLSDLTS DFPSSNWFSS
VLVQPNVNHK SKTVDVEIIL YPRKKNAMEL GVGFSTDGGV HGQIGWTKPW INSRGHSLRS
NLYLSAPKQT LEATYRMPLL KNPLNYYYDF AVGWEGEKEN DTNTRVLTLS ALRYWNNAHG
WQYFGGLRMR YDSFTQADIT DKTLLLYPTV GFTRTRLRGG SFATWGDVQK ITFDLSKRIW
LSESSFIKVQ ASSAWVRTYA ENHRVVARAE IGYLHTKGIE KIPPTLRFFA GGDRSVRGYG
YKKIAPKNRN GKLVGGSRLL TTSLEYQYQV YPNWWAATFA DSGLAADNYT AKELRYGTGV
GVRWASPVGA IKFDIATPIR DKDNSKNIQF YIGLGTEI
