TAMA_SALTS
ID TAMA_SALTS Reviewed; 577 AA.
AC E1WAU4;
DT 11-JUL-2012, integrated into UniProtKB/Swiss-Prot.
DT 30-NOV-2010, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=Translocation and assembly module subunit TamA;
DE AltName: Full=Autotransporter assembly factor TamA;
DE Flags: Precursor;
GN Name=tamA; OrderedLocusNames=SL1344_4342;
OS Salmonella typhimurium (strain SL1344).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=216597;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SL1344;
RX PubMed=22538806; DOI=10.1073/pnas.1201061109;
RA Kroger C., Dillon S.C., Cameron A.D., Papenfort K., Sivasankaran S.K.,
RA Hokamp K., Chao Y., Sittka A., Hebrard M., Handler K., Colgan A.,
RA Leekitcharoenphon P., Langridge G.C., Lohan A.J., Loftus B., Lucchini S.,
RA Ussery D.W., Dorman C.J., Thomson N.R., Vogel J., Hinton J.C.;
RT "The transcriptional landscape and small RNAs of Salmonella enterica
RT serovar Typhimurium.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:E1277-E1286(2012).
RN [2]
RP DISRUPTION PHENOTYPE.
RC STRAIN=SL1344;
RX PubMed=22466966; DOI=10.1038/nsmb.2261;
RA Selkrig J., Mosbahi K., Webb C.T., Belousoff M.J., Perry A.J., Wells T.J.,
RA Morris F., Leyton D.L., Totsika M., Phan M.D., Celik N., Kelly M.,
RA Oates C., Hartland E.L., Robins-Browne R.M., Ramarathinam S.H.,
RA Purcell A.W., Schembri M.A., Strugnell R.A., Henderson I.R., Walker D.,
RA Lithgow T.;
RT "Discovery of an archetypal protein transport system in bacterial outer
RT membranes.";
RL Nat. Struct. Mol. Biol. 19:506-510(2012).
CC -!- FUNCTION: Part of the translocation and assembly module (TAM)
CC autotransporter assembly complex, which functions in translocation of
CC autotransporters across the outer membrane. Has anion selective
CC channel-forming ability, but the physiological relevance of this
CC activity is unclear. {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- SUBUNIT: Interacts with TamB. {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- DOMAIN: Contains 3 N-terminal periplasmic polypeptide transport-
CC associated (POTRA) domains and a C-terminal 16-stranded beta-barrel
CC transmembrane region. The beta-barrel is closed on the extracellular
CC face by loop 6 (residues 456-495), while the C-terminal beta-strand
CC forms an inward kink which may act as a gate for substrate access from
CC the periplasm. This kink weakens the beta-strand pair between the first
CC and last strands which may contribute to gating and substrate
CC translocation. {ECO:0000250|UniProtKB:P0ADE4}.
CC -!- DISRUPTION PHENOTYPE: Significantly reduced survival in human serum,
CC probably due to complement-mediated killing.
CC {ECO:0000269|PubMed:22466966}.
CC -!- SIMILARITY: Belongs to the TamA family. {ECO:0000305}.
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DR EMBL; FQ312003; CBW20428.1; -; Genomic_DNA.
DR RefSeq; WP_001120231.1; NZ_QASL01000004.1.
DR AlphaFoldDB; E1WAU4; -.
DR SMR; E1WAU4; -.
DR EnsemblBacteria; CBW20428; CBW20428; SL1344_4342.
DR KEGG; sey:SL1344_4342; -.
DR PATRIC; fig|216597.6.peg.4835; -.
DR HOGENOM; CLU_018618_1_0_6; -.
DR OMA; NTTMLLY; -.
DR BioCyc; SENT216597:SL1344_RS22630-MON; -.
DR Proteomes; UP000008962; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR010827; BamA/TamA_POTRA.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR034746; POTRA.
DR InterPro; IPR035243; TamA_POTRA_Dom_1.
DR PANTHER; PTHR12815; PTHR12815; 1.
DR Pfam; PF01103; Omp85; 1.
DR Pfam; PF07244; POTRA; 1.
DR Pfam; PF17243; POTRA_TamA_1; 1.
DR PROSITE; PS51779; POTRA; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Membrane; Signal; Transmembrane;
KW Transmembrane beta strand; Virulence.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..577
FT /note="Translocation and assembly module subunit TamA"
FT /id="PRO_0000418089"
FT TRANSMEM 265..276
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 279..288
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 297..306
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 309..317
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 327..336
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 347..356
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 361..370
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 387..395
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 406..415
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 428..437
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 444..453
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 500..508
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 514..523
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 536..545
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 549..557
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT TRANSMEM 568..577
FT /note="Beta stranded"
FT /evidence="ECO:0000250|UniProtKB:P0ADE4"
FT DOMAIN 187..263
FT /note="POTRA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ SEQUENCE 577 AA; 64765 MW; FBA4A190173BF18C CRC64;
MPHIRQLCWV SLLCLSSSAV AANVRLKVEG LSGELEKNVR AQLSTIQSDE VTPDRRFRAR
VDDAIREGLK ALGYYEPTIK FDLLPPPAKG RQVLIARVTP GQPVLIGGTE VILRGGARTD
KDYLALLKTR PAIGTVLNQG DYDNFKKSLT SVSLRKGYFD SEFIKSQLGI ALGRHQAFWD
IDYDSGERYR FGPVTFEGSQ IRDEYLQNLL PFKEGDEYES KDLAELNRRL SATGWFNSVV
VAPEFEKSRK TKILPLKGVV SPRTENTIET GVGYSTDVGP RVKASWKKPW MNSYGHSLTT
STSISAPEQV LDFSYKMPLL KNPLEQYYLV QGGFKRTDLN DTEQDSTTLA VSRYWDLSSG
WQRAINLRWS FDHFTQGNVT NTTMLFYPGV MISRTRSRGG LMPTWGDSQR YSVDYSNTAW
GSDVDFSVLQ AQNVWIRTLY DRHRFVMRAN LGWIETGDFD KVPPDLRFFA GGDRSIRGYK
YKSISPKDSD GNLKGASKLA TGSLEYQYNV TGKWWGAVFV DSGEAVSDIR RSDFKTGTGV
GVRWASPVGP VKLDFAVPVG DKDEHGLQFY IGLGPEL