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BPPDA_BOTAL
ID   BPPDA_BOTAL             Reviewed;          13 AA.
AC   P0C7R7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   29-SEP-2021, entry version 23.
DE   RecName: Full=Bradykinin-potentiating peptide 13a {ECO:0000250|UniProtKB:Q6LEM5};
DE            Short=BPP-13a {ECO:0000250|UniProtKB:Q6LEM5};
OS   Bothrops alternatus (Urutu) (Rhinocerophis alternatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Bothrops.
OX   NCBI_TaxID=64174;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom;
RX   PubMed=18200607; DOI=10.1002/jms.1351;
RA   Souza G.H.M.F., Catharino R.R., Ifa D.R., Eberlin M.N., Hyslop S.;
RT   "Peptide fingerprinting of snake venoms by direct infusion nano-
RT   electrospray ionization mass spectrometry: potential use in venom
RT   identification and taxonomy.";
RL   J. Mass Spectrom. 43:594-599(2008).
CC   -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC       converting enzyme (ACE) and enhances the action of bradykinin by
CC       inhibiting the peptidases that inactivate it. It acts as an indirect
CC       hypotensive agent (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18200607}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..13
FT                   /note="Bradykinin-potentiating peptide 13a"
FT                   /evidence="ECO:0000269|PubMed:18200607"
FT                   /id="PRO_0000343181"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:18200607"
SQ   SEQUENCE   13 AA;  1388 MW;  6824FC97D83D6774 CRC64;
     QGGWPRPGPE IPP
 
 
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