AC102_NPVAC
ID AC102_NPVAC Reviewed; 122 AA.
AC P41482;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 23-FEB-2022, entry version 47.
DE RecName: Full=Protein Ac102;
DE AltName: Full=P12;
GN Name=Ac102;
OS Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX NCBI_TaxID=46015;
OH NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C6;
RX PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT virus.";
RL Virology 202:586-605(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=HR3;
RA Lu A., Craig A., Carstens E.B.;
RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP FUNCTION.
RX PubMed=12414968; DOI=10.1128/jvi.76.23.12281-12289.2002;
RA Ohkawa T., Rowe A.R., Volkman L.E.;
RT "Identification of six Autographa californica multicapsid
RT nucleopolyhedrovirus early genes that mediate nuclear localization of G-
RT actin.";
RL J. Virol. 76:12281-12289(2002).
RN [4]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=22592260; DOI=10.1099/vir.0.041848-0;
RA Gandhi K.M., Ohkawa T., Welch M.D., Volkman L.E.;
RT "Nuclear localization of actin requires AC102 in Autographa californica
RT multiple nucleopolyhedrovirus-infected cells.";
RL J. Gen. Virol. 93:1795-1803(2012).
RN [5]
RP FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH PROTEIN C42; P78/83
RP AND E27.
RX PubMed=29540600; DOI=10.1128/jvi.00111-18;
RA Hepp S.E., Borgo G.M., Ticau S., Ohkawa T., Welch M.D.;
RT "Baculovirus AC102 is a nucleocapsid protein that is crucial for nuclear
RT actin polymerization and nucleocapsid morphogenesis.";
RL J. Virol. 0:0-0(2018).
RN [6]
RP FUNCTION, AND INTERACTION WITH PROTEIN C42.
RX PubMed=29618641; DOI=10.1128/jvi.00005-18;
RA Zhang Y., Hu X., Mu J., Hu Y., Zhou Y., Zhao H., Wu C., Pei R., Chen J.,
RA Chen X., Wang Y.;
RT "Ac102 Participates in Nuclear Actin Polymerization by Modulating BV/ODV-
RT C42 Ubiquitination during Autographa californica Multiple
RT Nucleopolyhedrovirus Infection.";
RL J. Virol. 0:0-0(2018).
CC -!- FUNCTION: Nucleocapsid protein that mediates the translocation of G-
CC actin from the host cytoplasm to the nucleus, which is fundamental to
CC infection. Participates in regulating nuclear actin polymerization as
CC well as the morphogenesis and spatial distribution of viral capsid
CC structures in the host nucleus. Suppresses 'Lys-48'-linked
CC ubiquitination of the viral protein C42, thus forming a regulatory
CC cascade with C42 to control P78/83 availability as an nucleation
CC promoting factor (NPF). {ECO:0000269|PubMed:12414968,
CC ECO:0000269|PubMed:22592260, ECO:0000269|PubMed:29540600,
CC ECO:0000269|PubMed:29618641}.
CC -!- SUBUNIT: Interacts with protein C42; this interaction suppresses C42
CC 'Lys-48'-linked-ubiquitination and subsequent proteasomal degradation.
CC Interacts with proteins P78/83 AND E27. {ECO:0000269|PubMed:29540600,
CC ECO:0000269|PubMed:29618641}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:22592260,
CC ECO:0000269|PubMed:29540600}.
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DR EMBL; L22858; AAA66732.1; -; Genomic_DNA.
DR EMBL; U10885; AAB08768.1; -; Genomic_DNA.
DR PIR; G72862; G72862.
DR RefSeq; NP_054132.1; NC_001623.1.
DR GeneID; 1403935; -.
DR KEGG; vg:1403935; -.
DR Proteomes; UP000008292; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR009477; Baculo_Ac102.
DR Pfam; PF06497; DUF1098; 1.
PE 1: Evidence at protein level;
KW Host nucleus; Late protein; Reference proteome.
FT CHAIN 1..122
FT /note="Protein Ac102"
FT /id="PRO_0000133036"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 122 AA; 13335 MW; C744057DB26F4416 CRC64;
MIASINDTDM DTDDNMSQAR RNRRNRPPAR PSAQTQMAAV DMLQTINTAA SQTAASLLIN
DITPNKTESL KILSTQSVGA RSLLEPMQAN ASTIKLNRIE TVNVLDFLGS VYDNTIQVIV
TE