TANA_XENLA
ID TANA_XENLA Reviewed; 1744 AA.
AC Q01550;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Tanabin;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Tadpole head;
RX PubMed=1524825; DOI=10.1016/0896-6273(92)90180-l;
RA Hemmati-Brivanlou A., Mann R.W., Harland R.M.;
RT "A protein expressed in the growth cones of embryonic vertebrate neurons
RT defines a new class of intermediate filament protein.";
RL Neuron 9:417-428(1992).
CC -!- TISSUE SPECIFICITY: Growth cones of embryonic vertebrate neurons.
CC -!- DEVELOPMENTAL STAGE: Expressed in the neurula and persists during
CC embryogenesis in the brain, cranial nerves and spinal cord.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000255|PROSITE-ProRule:PRU01188}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M99387; AAA49966.1; -; mRNA.
DR PIR; JH0720; JH0720.
DR RefSeq; NP_001081326.1; NM_001087857.1.
DR AlphaFoldDB; Q01550; -.
DR SMR; Q01550; -.
DR GeneID; 397776; -.
DR KEGG; xla:397776; -.
DR CTD; 397776; -.
DR Xenbase; XB-GENE-865974; nes.S.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 397776; Expressed in heart and 14 other tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0019215; F:intermediate filament binding; IEA:InterPro.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR031211; Nestin.
DR PANTHER; PTHR47051; PTHR47051; 1.
DR Pfam; PF00038; Filament; 1.
DR SMART; SM01391; Filament; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Intermediate filament; Reference proteome.
FT CHAIN 1..1744
FT /note="Tanabin"
FT /id="PRO_0000063861"
FT DOMAIN 13..320
FT /note="IF rod"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01188"
FT REGION 1..12
FT /note="Head"
FT REGION 8..48
FT /note="Coil 1A"
FT REGION 49..60
FT /note="Linker 1"
FT REGION 61..156
FT /note="Coil 1B"
FT REGION 157..179
FT /note="Linker 12"
FT REGION 180..193
FT /note="Coil 2A"
FT REGION 194..199
FT /note="Linker 2"
FT REGION 200..314
FT /note="Coil 2B"
FT REGION 315..1744
FT /note="Tail"
FT REGION 341..372
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 785..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 976..996
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1485..1506
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1560..1722
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..369
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..996
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1032..1052
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1056..1093
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1371
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1443..1460
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1575..1659
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1744 AA; 199562 MW; 6502EAC9FE6C4E93 CRC64;
MEGYLASVSL GEESTQMWSL NKRLEAYLSR VKALEEENEL LRKEIHSLRS SKSERCWKKK
HHEEMMKLRD ALDDGHREMV QAEMVRDSIY EEIEFVKQRC LEEKQAREDA KKELSESKKL
LEEETRAQIW LKERLGQLEA ELEDILRDHE EEKALMEEEI ASFSQRLENF RVAPVAFKPV
EVDDYARKLS EIWQGAVEEY KSEVSVLEAG LSESKENLRK VLEENKQNRL LLQSLDKELV
SLKMRKEALE DLLSKQWQEQ KEEEEKLQRK AEALEQEKQD LRGQIAEVLE DRQQLMHLKM
SLSLEVATYR SLLEAESTRI YTDYRGSYTF NDSMLEHNNV RRRQSEDTRK TVSKDHRQSY
SKKQIGDKNE LQRPSLNNFS TVKSSAVPVR TSPVTKEFQK VSSVLQSQGL KYTKAPQVKE
VQTVSTVKSN LETHTFSGDA FRRAQVETRK TDEQVIKKDA LGLNDLNKNT GFKEEKDIQK
PGFMDHVVSK SVSSTEHKVP EIDPLESALK SLEEDLSSVS STFNAGQSSN LEAIKDVLGE
PICLENLQNE IAFEKESPGT NAAADPIEEV ISESVSYQTV HFEKQELSNL LEIENTHENH
VQDATQAFNS CEQDGHDRAS TLENNEPDVQ QYIRTLESNE IKESKIPSDN TEEAEIISKS
RKVFLENEYI PVSKDDLTEF TSHLENDSES SQSFDSKLFE NKSTEDQLIT NLKSNTQENI
FQSNQEHLEN LEFDSVVPDT VKFMYPQENN LLEEENVYGD GELVQMATDE NIINQSSDQL
LLSDHSHHEE TKTSESIAVE HNRMESEHAE VDKSSEIPVE ISENVSVEEI IHEISDVEED
TKQAFEDERV GEQINQNNQE STVDLDGSVY SQEENSQLEE DEVSISEQIE KDFEINEQEC
LKSDQIREAF DTEEVDHQVV DFMQEQSFER EVGQLNNIKQ EVDYLQNYDE DSFQNNDEPQ
ELESCDLQEQ KIKLEEENQL SENEGNQNFG GNDIEEFSQQ GYDTDEICQE TIGNQVSAQL
LCESDINQDK LSMEDEEEQN NPETEDNIGL EQESDQENTR SNEGTKFSQE ECDVVFKPED
MSDKSEYSGQ QEDLDKQVTD FSLNEQANND LLEKEEVILH HADDQRSVND EITIDEKLSE
RIIDNELATV DVNESLAANK EQVDLFTDEY AVDDNVGMQD DDSGQYQTKE DLFVDGNNII
EKIEIQQTSL LNQEICERVD NVDEDISGEA KNESVEMNDV VDLVPEAKVT GDEQISPLQD
EKLNLETMED TKDNDGQLCL EKENETEYIE VTDSPQFATD LSHDAGRELT VDQNSANLQF
CENPTKTLIA HHIEYETVAD SDLESTEEQV QETERIPFKP EDSKMENENS ESEESVDSQE
ISLNSHKSEE FEISKDYQLE QTLPDVTPLP NLEDEFEDLT EQPDVHEEHQ NNDDSGASTF
ITSVDEDKER EVRESVSKDE ESNEEEFGDV LSVDKTSQVE VTTLSGLAQE PSYLGDNEES
EDSMENAEIL NENPSNDIVD FMVSQMTETK IIIAEQVTEQ TEVTLQFDDA PNKLTENLNA
REKETYDYES NEENIEFTNE NQSASPANDI VDENQSEDSV ISDNEGTTSS YEDLPNATSI
SHVVALEESN ISTTEQSSTD TKRMTYEGYE ITSLQNVEDN AQETEKEFPS GVPLGQEDSR
SEDEELDDEG SEFSFGVNDE KANGEHKDVG EDDETEDMLN GHSQTGYSKI VLTSKKALRW
KRMF
