TANB_ARATH
ID TANB_ARATH Reviewed; 444 AA.
AC Q84M91; Q9MA86;
DT 18-SEP-2013, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable microtubule-binding protein TANGLED;
DE Short=AtTAN;
GN Name=TAN; Synonyms=ATN; OrderedLocusNames=At3g05330; ORFNames=T12H1.30;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Is required for spatial control cell division during plant
CC development. Through an association with microtubules, acts both for
CC the positioning of cytoskeletal arrays that establish planes of cell
CC division during prophase and for spatial guidance of expanding
CC phragmoplasts toward preestablished cortical division sites (CDS)
CC during cytokinesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with POK1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q84M91; Q27IK7: KIN12C; NbExp=2; IntAct=EBI-6881406, EBI-6881384;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, phragmoplast {ECO:0000250}.
CC Note=Preferentially localized to the preprophase band (PPB) during
CC early stage of mitotis and later localized to the cortical division
CC sites (CDS) during cytokinesis. {ECO:0000250}.
CC -!- CAUTION: In cv. Columbia, a naturally occurring frameshift at position
CC 444 results in a shortened C-terminus. A complete sequence for TAN can
CC be found in strain cv. Landsberg erecta (AC Q197W8). {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF27039.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009177; AAF27039.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE74221.1; -; Genomic_DNA.
DR EMBL; BT006478; AAP21286.1; -; mRNA.
DR EMBL; AK175941; BAD43704.1; -; mRNA.
DR EMBL; AK227452; BAE99455.1; -; mRNA.
DR RefSeq; NP_187184.2; NM_111406.5.
DR AlphaFoldDB; Q84M91; -.
DR BioGRID; 5032; 3.
DR DIP; DIP-46424N; -.
DR IntAct; Q84M91; 4.
DR STRING; 3702.AT3G05330.1; -.
DR PaxDb; Q84M91; -.
DR PRIDE; Q84M91; -.
DR EnsemblPlants; AT3G05330.1; AT3G05330.1; AT3G05330.
DR GeneID; 819697; -.
DR Gramene; AT3G05330.1; AT3G05330.1; AT3G05330.
DR KEGG; ath:AT3G05330; -.
DR Araport; AT3G05330; -.
DR TAIR; locus:2096279; AT3G05330.
DR eggNOG; KOG1674; Eukaryota.
DR HOGENOM; CLU_057223_1_0_1; -.
DR InParanoid; Q84M91; -.
DR OMA; NCKYIAN; -.
DR OrthoDB; 1087878at2759; -.
DR PhylomeDB; Q84M91; -.
DR PRO; PR:Q84M91; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q84M91; baseline and differential.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0005875; C:microtubule associated complex; IDA:TAIR.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0009524; C:phragmoplast; IEA:UniProtKB-SubCell.
DR GO; GO:0009574; C:preprophase band; IDA:TAIR.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0000911; P:cytokinesis by cell plate formation; IBA:GO_Central.
DR GO; GO:0000914; P:phragmoplast assembly; IMP:TAIR.
DR GO; GO:2000694; P:regulation of phragmoplast microtubule organization; IEA:InterPro.
DR InterPro; IPR044709; TAN1.
DR PANTHER; PTHR35728; PTHR35728; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Nucleus; Reference proteome.
FT CHAIN 1..444
FT /note="Probable microtubule-binding protein TANGLED"
FT /id="PRO_0000423586"
FT REGION 131..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 290..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 390..409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..156
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 171..186
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..218
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 444 AA; 49524 MW; 4B0C999AE9E4850B CRC64;
MVARTPQKQR KVAMVVPPLN SDLLKETINK VDKCMERLQE LQYTIAGGTK VVSGVNLSPR
STRIYLKTSL RCKQETLRIK NATNKKSPVG KFPASSPGDW RKMSLPAMLL GETVNEILQA
SQVTRDIVDA IAPKKSRKSR RLTMSQEDDG PKTPETQQKS REQNPETVSS NIKARRKKEK
QNRRSESDSP PSLQRARSRI AFRTISPQVK GNNGENSFRH LANRVSPKHK PWVKKAVLFP
NPLFISGTAT QQAKFSRTMS PVIARNEISS IKNNKETPYK FLIKSPPTSA SKFQVKIRSP
PKVLVSPTRN GSNSVRKSPR GSRSPTRTVN LGKKSASISP IRNTGKRSPK LSTAAKLRRS
FTPTRNGSNL ARKSSISPKR VTLQAFLSPT RNGNFCKKSP KASISPTRVC NKSQKLSTAA
KFRRSFSPSR LAMRFVSPMK SRKV
