TANC1_MOUSE
ID TANC1_MOUSE Reviewed; 1856 AA.
AC Q0VGY8; A2AUL4; A2AUL6; Q80VD2; Q8C0Q6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Protein TANC1;
DE AltName: Full=Tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1;
GN Name=Tanc1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Head, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-60; SER-1665; SER-1673 AND
RP SER-1674, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Lung, Pancreas, and
RC Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be a scaffold component in the postsynaptic density.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts probably directly with DLG1, DLG4, HOMER1. Interacts
CC with DLGAP1, INA, CAMK2A, GRIN2B and GRIA1. Interacts with TNIK and
CC MINK1 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0VGY8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0VGY8-2; Sequence=VSP_030829, VSP_030830, VSP_030831;
CC -!- PTM: Phosphorylated; by MINK1 and TNIK upon stimulation by RAP2A.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TANC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM27490.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAM27492.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK030022; BAC26741.1; -; mRNA.
DR EMBL; AL929160; CAM27490.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL929160; CAM27492.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC079914; AAH79914.1; -; mRNA.
DR EMBL; BC047437; AAH47437.1; -; mRNA.
DR CCDS; CCDS16054.1; -. [Q0VGY8-1]
DR RefSeq; NP_001277588.1; NM_001290659.1.
DR RefSeq; NP_938036.2; NM_198294.3. [Q0VGY8-1]
DR AlphaFoldDB; Q0VGY8; -.
DR SMR; Q0VGY8; -.
DR BioGRID; 211768; 4.
DR STRING; 10090.ENSMUSP00000036003; -.
DR iPTMnet; Q0VGY8; -.
DR PhosphoSitePlus; Q0VGY8; -.
DR EPD; Q0VGY8; -.
DR jPOST; Q0VGY8; -.
DR MaxQB; Q0VGY8; -.
DR PaxDb; Q0VGY8; -.
DR PeptideAtlas; Q0VGY8; -.
DR PRIDE; Q0VGY8; -.
DR ProteomicsDB; 263002; -. [Q0VGY8-1]
DR ProteomicsDB; 263003; -. [Q0VGY8-2]
DR Antibodypedia; 47958; 44 antibodies from 10 providers.
DR DNASU; 66860; -.
DR Ensembl; ENSMUST00000037526; ENSMUSP00000036003; ENSMUSG00000035168. [Q0VGY8-1]
DR Ensembl; ENSMUST00000139863; ENSMUSP00000123345; ENSMUSG00000035168. [Q0VGY8-1]
DR GeneID; 66860; -.
DR KEGG; mmu:66860; -.
DR UCSC; uc008jtj.2; mouse. [Q0VGY8-1]
DR UCSC; uc008jtk.1; mouse. [Q0VGY8-2]
DR CTD; 85461; -.
DR MGI; MGI:1914110; Tanc1.
DR VEuPathDB; HostDB:ENSMUSG00000035168; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000155655; -.
DR InParanoid; Q0VGY8; -.
DR OMA; TSENQRP; -.
DR PhylomeDB; Q0VGY8; -.
DR TreeFam; TF323159; -.
DR BioGRID-ORCS; 66860; 0 hits in 73 CRISPR screens.
DR ChiTaRS; Tanc1; mouse.
DR PRO; PR:Q0VGY8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q0VGY8; protein.
DR Bgee; ENSMUSG00000035168; Expressed in skin of external ear and 229 other tissues.
DR ExpressionAtlas; Q0VGY8; baseline and differential.
DR Genevisible; Q0VGY8; MM.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR GO; GO:0043679; C:axon terminus; IDA:MGI.
DR GO; GO:0030425; C:dendrite; IDA:MGI.
DR GO; GO:0098978; C:glutamatergic synapse; ISO:MGI.
DR GO; GO:0043025; C:neuronal cell body; IDA:MGI.
DR GO; GO:0099092; C:postsynaptic density, intracellular component; ISO:MGI.
DR GO; GO:0097062; P:dendritic spine maintenance; IMP:MGI.
DR GO; GO:0007520; P:myoblast fusion; IMP:MGI.
DR GO; GO:0099175; P:regulation of postsynapse organization; ISO:MGI.
DR GO; GO:0008542; P:visual learning; IMP:MGI.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 1.25.40.20; -; 3.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 10.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF48452; SSF48452; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 6.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; ANK repeat; Phosphoprotein;
KW Reference proteome; Repeat; Synapse; TPR repeat.
FT CHAIN 1..1856
FT /note="Protein TANC1"
FT /id="PRO_0000316960"
FT REPEAT 893..925
FT /note="ANK 1"
FT REPEAT 931..960
FT /note="ANK 2"
FT REPEAT 964..993
FT /note="ANK 3"
FT REPEAT 997..1026
FT /note="ANK 4"
FT REPEAT 1037..1066
FT /note="ANK 5"
FT REPEAT 1075..1104
FT /note="ANK 6"
FT REPEAT 1108..1137
FT /note="ANK 7"
FT REPEAT 1141..1170
FT /note="ANK 8"
FT REPEAT 1174..1203
FT /note="ANK 9"
FT REPEAT 1207..1236
FT /note="ANK 10"
FT REPEAT 1240..1269
FT /note="ANK 11"
FT REPEAT 1286..1319
FT /note="TPR 1"
FT REPEAT 1333..1366
FT /note="TPR 2"
FT REPEAT 1368..1400
FT /note="TPR 3"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 58..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..296
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 437..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1417..1597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1636..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1832..1856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..45
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..82
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..480
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1441..1457
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1486..1556
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1652..1690
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1698..1712
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0D5"
FT MOD_RES 60
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 63
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0D5"
FT MOD_RES 64
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0D5"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0D5"
FT MOD_RES 267
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0D5"
FT MOD_RES 462
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0D5"
FT MOD_RES 1436
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6F6B3"
FT MOD_RES 1463
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6F6B3"
FT MOD_RES 1665
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1673
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1674
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..102
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030829"
FT VAR_SEQ 1079..1092
FT /note="ALTAAAGRGKVEIC -> GNYASSVCSQQPRA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030830"
FT VAR_SEQ 1093..1856
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030831"
FT CONFLICT 166
FT /note="L -> M (in Ref. 1; BAC26741)"
FT /evidence="ECO:0000305"
FT CONFLICT 209
FT /note="I -> N (in Ref. 1; BAC26741)"
FT /evidence="ECO:0000305"
FT CONFLICT 1102
FT /note="V -> L (in Ref. 3; AAH79914)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1856 AA; 200805 MW; 5CD2DD065C564E33 CRC64;
MLKAVLKKSR EGGKGSKKEA GGDFGSETPA LSSSGDSPVN SLSTTEDTYR VSLAKGVSMS
LPSSPLLPRQ SLLTQSRSNK KSPGPVRKPK YVESPRVPGD PVMIPFGEGS KPSEPSATEA
KADNEPSCSP AAQELLTRLG FLLGEGIPSA THITIEDKNE AMCTALSQGI SPCSTLTSST
ASPSTDSPCS TLNSCVSKTA ASKSPCETIS SPSSTLESKD SGIIATITSS SENDDRSGSS
LEWNRDGSLR LGVQKGVLHD RRADNCSPVA EEETTGSAES VLPKAEPSAG DGPVPYPQSS
GSLIMPRPNS VAATSSTKLE DLSYLDGQRN APLRTSIRLP WHNTAGGRAP EVKARFAPYK
PQEILLKPLL FEVPSITTDS VFVGRDWLFH QIEENLRNTE LAENRGAVVV GSVGFGKTAI
ISKLVALSCH GSRMRQIASS SPSLSPKSSD PTQDLPGTPL LSPSSSTSAL SVTRTPAGPG
TADSQRPRED AVKYLASKVV AYHYCQADNT YTCLVPEFVH SIAALLCRSH QLAAYRDLLI
KEPQLQSMLS LRSCVQDPVA AFKRGVLEPL TSLRNEQKIP EEEYIILIDG LNEAEFHKPD
YGDTLSSFIT KIIPKFPTWL KLIVTVRANF QEIISALPFV KLSLDDFPDN KDIHSDLHAY
VQHRVHSSQD ILSNISLNGK ADAALISKVS SHLVLRSLGS YLYLKLTLDL FQRGHLVIKS
ASYKVVPVSL SELYLLQCNM KFMTQSAFDR ALPILNVALA SLHPMTDEQI FQAINAGHIQ
GEQGWEDFQQ RMEALSCFLI KRRDKTRMFC HPSFREWLVW RADGESTAFL CEPRNGHALL
AFMFSRQESK LNRQQTMELG HHILKAHIFK GLSKKTGVSS SHLQALWIGY STEGLSAALA
SLRNLYTPNV KVSRLLILGG ANVNYRTEVL NNAPILCVQS HLGHEEVVTL LLEFGACLDG
MSENGMNALC YAAAAGHMKL VCLLIKKGAR VDHLDKKGQC ALVHSALRGH SDILQYLLNC
EWSAGPPQPG TLRKSQALQQ ALTAAASMGH SSVVQSLLGM AEEHEIEVNG TDTLWGETAL
TAAAGRGKVE ICELLLERGA AVSRANRRGV PPLFCAARQG HWQVVRLLLD RGCDVNLSDK
QGRTPLMVAS CEGHLSTVEF LLSKGAALSS LDKEGLSALS WACLKGHRAV VQYLVEEGAE
IDQTDKNGRT PLDLAAFYGD AETVLYLVEK GAVIEHVDHS GMRPLDRAIG CRNTAVVVTL
LRKGAKLGNA AWAMATSKPD ILIILLQKLV EEGNVMYKKG KMKEAAQRYQ YALRKFPREG
LGEDMRPFNE LRVSLYLNLS RCRRKTNDFG LAEEFASKAL ELKPKSYEAF YARARAKRNS
RQFLAALADL QEAVKLCPNN QEIKRLLARV EEECKQLQRN QQQKQQGPPP APANDSDNEE
DAPASSLKDH FPIEEAEEED TSSQEESISP TPRSQPPPSV PSPYIRNLQE GLQSKGRSAS
PQSRAGISKS LRETVAQSGL VMQPTKQAQI VKTNQHLGSG QSSMRNSSTK IQVSSQNPPP
SPMPGRVSAA PAVSRNQHLE GTGPFTAGTG CGHFGDRLGA SQSLQLQRSE SGTAYPLPSK
VKAAERLLAH ASVAVDMAPP NQGGPVSCSD VRHPASLSSS GSSGSPSSSI KMSSSTSSLT
SSSSVSDGFK VQGPDSRIRD KGTTQVQGGT AEHRPRNTPF MGIMDKTARF QQQSNPPNRS
WHCPVAEGLL TNTATAAGLQ SNSEKPTLKP GGYCSQAKPC SVPPLSMGVH NGAQVKELEE
NKCQIPALCQ DNRITKGVPH LYPEGVSKQP LHVSTEAHRS HLTSAKPKRS FIESNV
