ID   BPPF_PROMU              Reviewed;          11 AA.
AC   P0C7S7;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   29-SEP-2021, entry version 22.
DE   RecName: Full=Bradykinin-potentiating peptide TmF;
DE            Short=BPP-TmF;
OS   Protobothrops mucrosquamatus (Taiwan habu) (Trimeresurus mucrosquamatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Crotalinae; Protobothrops.
OX   NCBI_TaxID=103944;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom;
RX   PubMed=12883631;
RA   Jia Y.-H., Li D.-S., Zhu S.-W., Zhang L.-Y., Ding L.-S., Wang W.-Y.,
RA   Xiong Y.-L.;
RT   "Characterization of a new bradykinin-potentiating peptide (TmF) from
RT   Trimeresurus mucrosquamatus.";
RL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao 35:619-623(2003).
CC   -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC       converting enzyme (ACE) and enhances the action of bradykinin by
CC       inhibiting the peptidases that inactivate it. It acts as an indirect
CC       hypotensive agent. {ECO:0000269|PubMed:12883631}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12883631}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:12883631}.
CC   -!- MASS SPECTROMETRY: Mass=1110.7; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:12883631};
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..11
FT                   /note="Bradykinin-potentiating peptide TmF"
FT                   /id="PRO_0000343191"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:12883631"
SQ   SEQUENCE   11 AA;  1128 MW;  30BABF1277687737 CRC64;
     QGRPLGPPIP P