TANT_DROME
ID TANT_DROME Reviewed; 299 AA.
AC Q8T0D4; Q9NHW6; Q9VRT0;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Protein tantalus;
GN Name=tant {ECO:0000312|FlyBase:FBgn0028980};
GN Synonyms=tan {ECO:0000312|FlyBase:FBgn0028980};
GN ORFNames=CG6586 {ECO:0000312|FlyBase:FBgn0028980};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND INTERACTION WITH ASX.
RC TISSUE=Embryo;
RX PubMed=11397012; DOI=10.1006/dbio.2001.0255;
RA Dietrich B.H., Moore J., Kyba M., dosSantos G., McCloskey F., Milne T.A.,
RA Brock H.W., Krause H.M.;
RT "Tantalus, a novel ASX-interacting protein with tissue-specific
RT functions.";
RL Dev. Biol. 234:441-453(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-204 AND SER-264, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
CC -!- FUNCTION: Potential cofactor involved in sensory organ development.
CC Despite its interaction with the Polycomb group protein Asx, it does
CC not regulate the expression of homeotic genes.
CC {ECO:0000269|PubMed:11397012}.
CC -!- SUBUNIT: Binds to DNA in vitro. Interacts directly with Asx.
CC {ECO:0000269|PubMed:11397012}.
CC -!- INTERACTION:
CC Q8T0D4; Q9V727: Asx; NbExp=3; IntAct=EBI-139891, EBI-103394;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11397012}. Cytoplasm
CC {ECO:0000269|PubMed:11397012}. Chromosome
CC {ECO:0000269|PubMed:11397012}. Note=In embryos, it is predominantly
CC cytoplasmic. In third instar larvae, it is predominantly nuclear or
CC cytoplasmic depending on tissues. Colocalizes with Asx on many binding
CC sites on polytene chromosomes, but does not bind to homeotic genes
CC loci.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed in precellularized embryos.
CC Then it decreases at cellular blastoderm to increase again during germ
CC band extension. During germ band extension, it is highly expressed in
CC somatic and visceral mesoderm. Ubiquitously expressed in imaginal
CC disks. In ovary, it is expressed from stage 10.
CC {ECO:0000269|PubMed:11397012}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:11397012}.
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DR EMBL; AF218585; AAF26736.1; -; Genomic_DNA.
DR EMBL; AE014296; AAF50710.2; -; Genomic_DNA.
DR EMBL; AY069394; AAL39539.1; -; mRNA.
DR RefSeq; NP_001261460.1; NM_001274531.1.
DR RefSeq; NP_524782.2; NM_080043.3.
DR AlphaFoldDB; Q8T0D4; -.
DR BioGRID; 69276; 5.
DR IntAct; Q8T0D4; 2.
DR STRING; 7227.FBpp0305582; -.
DR iPTMnet; Q8T0D4; -.
DR PaxDb; Q8T0D4; -.
DR DNASU; 44785; -.
DR EnsemblMetazoa; FBtr0077043; FBpp0076751; FBgn0028980.
DR EnsemblMetazoa; FBtr0333390; FBpp0305582; FBgn0028980.
DR GeneID; 44785; -.
DR KEGG; dme:Dmel_CG6586; -.
DR UCSC; CG6586-RA; d. melanogaster.
DR CTD; 44785; -.
DR FlyBase; FBgn0028980; tant.
DR VEuPathDB; VectorBase:FBgn0028980; -.
DR eggNOG; ENOG502TBX4; Eukaryota.
DR HOGENOM; CLU_081405_0_0_1; -.
DR InParanoid; Q8T0D4; -.
DR OMA; VYDFAKI; -.
DR OrthoDB; 1239744at2759; -.
DR PhylomeDB; Q8T0D4; -.
DR SignaLink; Q8T0D4; -.
DR BioGRID-ORCS; 44785; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 44785; -.
DR PRO; PR:Q8T0D4; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0028980; Expressed in testis and 36 other tissues.
DR ExpressionAtlas; Q8T0D4; baseline and differential.
DR Genevisible; Q8T0D4; DM.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007423; P:sensory organ development; IMP:UniProtKB.
DR InterPro; IPR028149; Tantalus-like.
DR Pfam; PF15386; Tantalus; 1.
PE 1: Evidence at protein level;
KW Chromosome; Cytoplasm; Developmental protein; DNA-binding; Nucleus;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..299
FT /note="Protein tantalus"
FT /id="PRO_0000072429"
FT REGION 16..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..86
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 264
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 63
FT /note="H -> Q (in Ref. 1; AAF26736)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 299 AA; 33766 MW; D087870EC0B16233 CRC64;
MDNIVYDFAK ITFQAKDNRS PTTNSNLSWQ LNQMALSDME EMQDTSEPIA PPESDDNVSS
ESHDSDDVDS QLSRCEDNDD DSDCISGSSR RSSTFGARAG VARRRMPARV SKDNFNRICS
AIMKPIKKKQ RKELNTNAQT LKSIEKIYTS RRMKKFTPTN LETIFEEPSD ENAADAEDDS
EECSISSQVK VVKVWGRKLR RAISFSDGLN KNKILSKRRR QKVKKTFGKR FALKKISMTE
FHDRLNKSFD SAMLEGDDAE AGGSAEAVNI PKTSMTMEDI QLPTMSSQHQ FLMQPAGFE
