ID   BPPL_BITRH              Reviewed;          10 AA.
AC   P0DV81;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Bradykinin-potentiating peptide-like {ECO:0000303|PubMed:28670326};
DE   AltName: Full=Bothrops-like BPP;
OS   Bitis rhinoceros (West African gaboon viper) (Vipera rhinoceros).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Bitis.
OX   NCBI_TaxID=715877;
RN   [1]
RP   PROTEIN SEQUENCE, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR
RP   LOCATION, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom;
RX   PubMed=28670326; DOI=10.1186/s40409-017-0124-9;
RA   Fucase T.M., Sciani J.M., Cavalcante I., Viala V.L., Chagas B.B.,
RA   Pimenta D.C., Spencer P.J.;
RT   "Isolation and biochemical characterization of bradykinin-potentiating
RT   peptides from Bitis gabonica rhinoceros.";
RL   J. Venom. Anim. Toxins Incl. Trop. Dis. 23:33-33(2017).
CC   -!- FUNCTION: Bradykinin-potentiating peptide. It inhibits the activity of
CC       the angiotensin-converting enzyme (ACE) by a preferential interaction
CC       with its C-domain. It evokes transient hypotension.
CC       {ECO:0000250|UniProtKB:P68515}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28670326}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:28670326}.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
CC   -!- CAUTION: Two different sequences are presented in the text and in Fig.4
CC       for the same peptide in Fucase et al., 2017.
CC       {ECO:0000305|PubMed:28670326}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Pyrrolidone carboxylic acid; Secreted; Toxin.
FT   PEPTIDE         1..10
FT                   /note="Bradykinin-potentiating peptide-like"
FT                   /evidence="ECO:0000269|PubMed:28670326"
FT                   /id="PRO_0000455656"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:28670326"
FT   CONFLICT        5
FT                   /note="H -> R (in Ref. 1; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   10 AA;  1213 MW;  30C53546C761F773 CRC64;
     QNWPHPQIPP