ID   BPPS_LYCER              Reviewed;          11 AA.
AC   P0C7S8;
DT   01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-2008, sequence version 1.
DT   29-SEP-2021, entry version 20.
DE   RecName: Full=Bradykinin-potentiating peptide S;
DE            Short=BPP-S;
OS   Lycosa erythrognatha (Wolf spider) (Scaptocosa raptoria).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae;
OC   Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Lycosa.
OX   NCBI_TaxID=332789;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Venom;
RX   PubMed=8783454; DOI=10.1016/0041-0101(96)00010-4;
RA   Ferreira L.A.F., Alves W.E., Lucas M.S., Habermehl G.G.;
RT   "Isolation and characterization of a bradykinin potentiating peptide (BPP-
RT   S) isolated from Scaptocosa raptoria venom.";
RL   Toxicon 34:599-603(1996).
CC   -!- FUNCTION: This peptide potentiates the effects of bradykinin on smooth
CC       muscle, and inhibits the angiotensin-converting enzyme (ACE) in vitro.
CC       {ECO:0000269|PubMed:8783454}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8783454}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:8783454}.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   ArachnoServer; AS000001; Bradykinin-1-Lycosa erythrognatha.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Metalloenzyme inhibitor;
KW   Metalloprotease inhibitor; Protease inhibitor; Pyrrolidone carboxylic acid;
KW   Secreted.
FT   PEPTIDE         1..11
FT                   /note="Bradykinin-potentiating peptide S"
FT                   /id="PRO_0000343197"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:8783454"
SQ   SEQUENCE   11 AA;  1208 MW;  293734E541AAB773 CRC64;
     QAPWPDTISP P